PYRALVEX® is a drug based on Salicylic acid + glucosidic rhubarb extract
THERAPEUTIC GROUP: Antiinfectives and antiseptics for local oral treatment
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Indications PYRALVEX ® Salicylic acid + rhubarb glucosidic extract
PYRALVEX® is a drug indicated as a local antiseptic during oral infections such as gingivitis, stomatitis, oro-pharyngitis and alveolar pyorrhea.
Mode of action PYRALVEX ® Salicylic acid + rhubarb glucosidic extract
The antiseptic and anti-infective action of PYRALVEX® is due to the presence of two important active ingredients, used in this case for local use: salicylic acid and rhubarb extract.
Salicylic acid is a carboxylic acid of natural origin, endowed with a natural exfoliating and anti-inflammatory activity, which in small doses and for topical use is important for its keratolytic and bacteriostatic effect, therefore useful in controlling the evolution of inflammatory lesions and infectious.
The high irritating power, vis-à-vis the gastric mucosa, obviously limits it, limiting it to the topical route.
The glucidic extract of rhubarb is instead endowed with a high anti-inflammatory and analgesic activity, useful in soothing the mucosa subjected to inflammatory stimulus, facilitating its recovery and at the same time guaranteeing an improvement in the clinical picture.
Recent scientific evidence has attributed to this last active ingredient also an antiseptic and antibacterial activity, particularly effective against the gram-positive and gram-negative bacteria of the oral cavity, and facilitated by the presence of salicylic acid, which guarantees a greater permeability of these extracts in the mucosa subjected to microbiological action.
Studies carried out and clinical efficacy
THE PYRALVEX IN THE CLINICAL PRACTICE
Treatment results of various oral diseases wih the Pyralvex preparation.
Maresch-Lewandowska M.
Czas Stomatol. 1981 Oct; 34 (10): 1013-5. Polish.
Dated work that demonstrates the effectiveness of the association between salicylic acid and rhubarb extract in the treatment of infectious diseases of the oral cavity, resulting generally well tolerated.
PYRALVEX AND AFTE OF THE ORAL CABLE
Inf Dent. 1977 Nov 24; 59 (47): 45-50.
Clinical work that demonstrates the efficacy of Pyralvex in reducing the extent of oral lesions, to guarantee complete remission, in a completely smooth and effective manner.
PYRALVEX AND GINGIVITE
SSO Schweiz Monatsschr Zahnheilkd. 1980 Aug; 90 (8): 718-24.
Interesting study that assessed the ability of Pyralvex to inhibit plaque formation, thus reducing the subsequent risk of gingivitis.
Method of use and dosage
PYRALVEX®
Topical solution with 0.5 g of rhubarb glucosidic extract and 0.1 g of salicylic acid per 100 ml of solution.
The therapeutic protocol foresees the application of 3-4 brushstrokes per day on the region of the oral mucosa affected by the inflammatory process.
Warnings PYRALVEX ® Salicylic acid + rhubarb glucosidic extract
Prolonged use of PYRALVEX® could lead to the appearance of local sensitization reactions, sometimes serious enough to require suspension of therapy.
If the lesions do not improve following the application of PYRALVEX®, it would be advisable to consult your doctor and provide for an adjustment of the ongoing therapy.
It is always important to consider that sometimes the lesions of the oral mucosa can be the first signs of clinically relevant systemic pathologies.
It is recommended to avoid ingestion of the drug and contact with the eyes.
PREGNANCY AND BREASTFEEDING
The topical use of the product, the absence of noteworthy systemic absorption of its active ingredients and the lack of studies able to characterize the safety profile of the drug for fetal health, make the potential effects of PYRALVEX® for unpredictable fetal health.
For this reason its use during pregnancy should be limited exclusively to cases of real need, fulfilling under the supervision of your doctor.
Interactions
Drug interactions worthy of clinical note are currently unknown.
Contraindications PYRALVEX ® Salicylic acid + rhubarb glucosidic extract
The use of PYRALVEX® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients.
Undesirable effects - Side effects
The use of PYRALVEX® could lead to local adverse reactions due to hypersensitization with damage to the oral mucosa.
Fortunately, the most clinically relevant adverse reactions are rarer.
Note
PYRALVEX® is a non-prescription drug.
