MODULA ® Policarbofil Calcico

MODULA ® is a calcium polycarbonate-based drug

THERAPEUTIC GROUP: Laxatives - Mass-forming laxatives

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications MODULA ® Policarbofil Calcico

MODULA ® is indicated for the short-term treatment of occasional constipation and non-specific diarrhea.

Mode of action MODULA ® Policarbofil Calcico

The calcium polycarbonate contained in MODULA ® is an important adaptogen, which can be used effectively both in the treatment of occasional constipation and diarrhea.

Its action is essentially due to its ability to absorb water in the intestinal lumen, for a quantity equal to 60-120 times its weight.

Introduced orally, following the substitution of calcium ions with hydrogen ions at gastric level, the calcic polycarbon is reshaped with polycarbophilic acid, thus reaching the intestine, where it hydrates, decisively increasing its volume and facilitating evacuation.

The ability to bind water, present for example in watery stools, allows the active ingredient to be effectively used also for the treatment of diarrheal episodes.

Studies carried out and clinical efficacy

POLYCARABOFIL CALCICUS AND IRRITABLE COLON SYNDROME

Irritable bowel syndrome is a very common condition, characterized by gastrointestinal disorders, dyspepsia, diarrhea, constipation, and alternating diarrhea and constipation. Studies have shown that polycarbonate calcium can be particularly effective especially in the treatment of the form characterized by constipation, guaranteeing a regression of symptoms.

2. POLICARABOFIL CALCICO AND NUTRIENT ABSORPTION

Although the ability of this active ingredient to inhibit the absorption of glucidic derivatives and amino acids such as phenylalanine has been observed in vitro, other studies have quickly denied these experimental evidences, claiming that the calcic polycarbon is absolutely not interfering with the absorption of nutrients.

3.POLICARBOFIL CALCICO AND Diarrhea

This mass laxative was particularly useful also in the treatment of diarrhea episodes, thanks to the possibility of absorbing water from watery stools. In fact, studies show that the administration of this drug can guarantee a reduction in painful symptoms and an increase in stool consistency in patients with non-specific diarrhea.

Method of use and dosage

MODULA ® tablets for oral use from 0.652 grams of calcic polycarbonate; chewable tablets of 0.625 gr of calcic polycarbonate; granules for oral use of 37.4 g of polycarbonate calcic / 100gr : the range of application used for the treatment of constipation involves an intake ranging from two tablets, taken once a day, to the two tablets taken four times a day. It is preferable to start with the minimum dosage, and then possibly - also based on the result observed - correct the doses.

To increase the effectiveness of MODULA ® it is useful to take plenty of water during the day, while to avoid digestive side effects it is advisable not to lie down immediately after taking it.

Any alterations in the dosage or therapeutic protocol should be established solely by the physician.

Warnings MODULA ® Policarbofil Calcico

MODULA ® should be taken in case of real need and only in conditions of occasional constipation, for very limited periods of time.

Prolonged treatment with this medicine could in fact jeopardize the patient's state of health (especially if he or she is cardiopathic), following a reduction in blood levels of potassium and dehydration. These effects are also accompanied by a reduction in the effectiveness of the treatment, with a progressive reduction of intestinal peristalsis up to atony.

Medical supervision is strongly recommended in patients suffering from hypertension, cardiovascular diseases and endocrine-metabolic disorders, as well as in pediatric patients.

MODULA ® absolutely does not interfere with the normal ability to drive vehicles and use machinery.

PREGNANCY AND BREASTFEEDING

At the moment there are no studies that can demonstrate the total safety of the calcium polycarbonate on the health of the fetus and the newborn, when taken during pregnancy or during breastfeeding; however, pharmacokinetic evidence shows that the active ingredient is not completely absorbed by the gastro-intestinal tract.

In light of these data, during pregnancy it would be advisable to use MODULA ® only in cases of real need and under strict medical supervision.

Interactions

MODULA ®, like other laxatives, is able to significantly increase the speed of intestinal transit, altering the normal absorption profile of nutrients and active ingredients. Therefore, taking laxatives should be done at least two hours after the ingestion of drugs.

Contraindications MODULA ® Policarbofil Calcico

MODULA ® is contraindicated in case of hypersensitivity to the active substance or to one of its excipients.

The use of laxatives is also contraindicated in case of intense abdominal pains, nausea, vomiting, diarrhea, gastro-intestinal affections, even with acute course, bedridden patients, dehydration and in case of intestinal obstruction.

Undesirable effects - Side effects

The most obvious side effects are associated with abdominal distension induced by the increase in fecal mass; therefore, even if only occasionally, abdominal pains, cramps and colic, flatulence and intestinal obstructions have been observed.

The prolonged use of laxatives is instead associated with the appearance of electrolyte imbalances, with consequent dehydration, intestinal atony and chronic constipation.