MIDIUM ® - Vitamin complex

MIDIUM ® is a drug based on vitamins A, E and B6.


IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions MIDIUM ® - Vitamin complex

MIDIUM ® is indicated in the prevention and treatment of vitamin deficiency states, associated with malabsorption syndromes or severe malnutrition.

Mechanism of action MIDIUM ® - Vitamin complex

MIDIUM ® is a polyvitamin consisting of two very important fat-soluble vitamins, such as vitamin A and vitamin E and a water-soluble vitamin B6.

Retinol (vitamin A) and tocopherol (vitamin E), introduced orally, are absorbed at the intestinal level through a mediated absorption of bile, and transported in circulation, in particular to the liver, linked to specific plasma proteins, from where they are subsequently sorted to various fabrics.

More precisely, vitamin E strengthens the pull of endogenous antioxidants, protecting cellular structures from deterioration induced by reactive oxygen species, regulating gene expression, controlling the cell's main activities, modulating the synthesis of inflammatory cytokines to favor of anti-aggregation and vasodilator factors.

Vitamin A, on the other hand, in addition to being part of the synthesis of rhodopsin, a pigment present at the retinal level and fundamental for night vision, interacting through specific intracellular receptors is able to control gene expression by supporting proliferation and the differentiation of high-turnover cells over, like those of the immune and hematopoietic system.

Pyridoxine (vitamin B6), while representing the only water-soluble vitamin contained in MIDIUM ®, is crucial in supporting the metabolic functions, and in particular the energy ones, and in directing the synthesis of steroid hormones and neurotransmitters such as GABA and dopamine.

Studies carried out and clinical efficacy


Clin Lab. 2011; 57 (11-12): 939-46.

Study demonstrating how supplementation with vitamin A, E and B vitamins could prove useful in reducing the mortality rate from cardiovascular events in end-stage renal disease patients.


J Appl Physiol. 2011 Dec 29.

Work demonstrating how supplementation with vitamin A, E and C can significantly reduce plasma concentrations of inflammatory cytokines such as IL-6 following intense training. This state is also often accompanied by an increase in the protein synthesis of enzymes involved in the detoxification process.


Matern Child Nutr. 2011 Nov 20.

Study demonstrating that supplementing with vitamin A in lactating women may lead to a reduction in vitamin E concentrations in colostrum. For this reason, more complete integration could be envisaged.

Method of use and dosage


Soft gelatin capsules containing 49.5 mg of vitamin A palmitate, 180 mg of alpha tocopheryl acetate and 180 mg of pridioxin hydrochloride.

Taking one tablet a day, preferably with meals, is able to satisfy the most demanding needs, significantly improving the condition of patients with serious deficiencies.

It is advisable to carry out 21-day intake cycles, to be repeated as required by your doctor.

Warnings MIDIUM ® - Vitamin complex

Although MIDIUM ® can be sold without a prescription, in order to avoid overdoses and symptoms of hypervitaminosis, it would be useful to consult your doctor beforehand.

MIDIUM ® contains peanut oil, hydrogenated vegetable oils and soybean oil, which causes hypersensitivity in predisposed and atopic patients.

It is important to keep the drug away from children.


The high dosages of vitamin A present in MIDIUM ®, suggest extending the contraindications related to the use of this medicine also to pregnancy and the subsequent period of breastfeeding, given the potential toxic and teratogenic effects performed by high concentrations of retinol on the unborn child .


The simultaneous assumption of MIDIUM ® with:

  • Estro progestinici, could determine the increase in blood concentrations of vitamin A;
  • Insulin, could potentiate the hypoglycemic effect of this hormone;
  • Anticoagulants, non-steroidal anti-inflammatory drugs or antiplatelet agents, could lead to an increased risk of bleeding.

Contraindications MIDIUM ® - Vitamin complex

MIDIUM ® is contraindicated in case of hypersensitivity to active ingredients or related excipients.

Undesirable effects - Side effects

MIDIUM ®, when taken according to medical indications, is free of side effects and well tolerated.

The administration at high doses or continued for too long periods of time, could determine the establishment of a hypervitaminosis condition, responsible for loss of appetite, weight loss, itching, headaches, hepatosplenomegaly, nausea and vomiting.

In all these cases it would be appropriate to immediately stop taking the drug, until the symptoms are remitted.


MIDIUM ® is a salable drug without a prescription