About Cm2 Nitrate - SAN
CM2 NITRATE - SAN
Food supplement based on arginine, beta alanine and creatine
FORMAT
Pack of 240 capsules
COMPOSITION
Di - Arginine malate
Beta Alanine
Creatine nitrate
Bulking agents: calcium carbonate, cellulose
Anti-binder: stearic acid, cross-linked carboxymethylcellulose, silicon dioxide and magnesium stearate
Coating agent: hydroxypropyl methylcellulose
PER PORTION (3 capsules): Di-arginine Malate 666 mg - Beta Alanine 533 mg - Creatine nitrate 333 mg
Arginine is a conditionally essential amino acid, whose needs can be met both by endogenous synthesis and dietary intake. Introduced orally through foods such as peanuts, legumes and meat, arginine is absorbed at duodenal level, representing an important source of energy and plastic for enterocytes. The portion not used by these cells, is introduced into the circulation from the basolateral portion and reaches the various body districts, in particular the liver, where it supplies the urea cycle, thus guaranteeing the ammonia detoxification.
In the overall metabolic-functional balance, this amino acid is included in:
- strengthening of immune defenses (as used by cells in active and intense replication);
- in the creatine agreement: together with glycine and methionine;
- in protein synthesis;
- in the synthesis of collagen, polyamines and proline, facilitating reparative phenomena;
- in allowing the synthesis of glucose starting from non-glucidic precursors (gluconeogenesis)
In sports practice, its use is mainly due to two very important potentials:
- Precursor of nitric oxide: a powerful vasodilator that would allow a better flow of oxygen and nutrients at the muscular level;
- Inducer of GH secretion: which would ensure an increase in lean mass at the expense of fat.
However, it is necessary to remember that both processes are quite complicated and do not depend only on the availability of the substrate, but on a complex of metabolic and physiological situations that are difficult to reproduce. Most of the studies published in the literature define arginine as useful in improving physical performance, delaying the onset of anaerobic metabolism and improving maximum peak strength.
Beta Alanine - amino acid characterized by an alternative chemical structure, with the presence of the amino group in beta position. This structural peculiarity significantly affects the functionality of beta alanine, so much so that, unlike other amino acids (L-amino acids), it does not participate in the process of protein synthesis. Despite this limitation, beta alanine is a major part of muscle metabolism, in the form of carnosine. Carnosine is a dipeptide consisting of beta alanine and histidine, synthesized in the liver and stored mainly in the brain (about 5 mM) and muscle (skeletal) (about 20 mM); it guarantees:
- protective action against free radicals;
- stabilizing action of cell membranes;
- protective action against muscle damage induced by intense exercise;
- Better calcium homeostasis, and greater sensitivity of muscle fibers;
- A buffering action on muscular acidosis;
- An increase in energy availability;
Creatine nitrate - creatine salt obtained by adding a nitrate group. The efforts made to obtain this compound go beyond improving the kinetics or the degree of absorption, and are directed towards the vasodilatory function induced by the release of nitric oxide, which should follow the ingestion of this product. Despite the potential benefits described by various manufacturers, even in the reduction of gastrointestinal side effects, significant trials are lacking in this regard.
About 95% of the total creatine content of the human body is present in the skeletal muscle, most of it in the form of phospho-creatine, representing a ready-to-use energy reserve for muscle fibers. During the first minute of intense physical activity, the contraction of muscle fibers, in particular those of type II, is supported by phosphocreatine, which is able to transfer its phosphate group to ADP, guaranteeing the synthesis of ATP necessary for the slipping of the filaments actinic on myosin heads and subsequent contraction. Creatine muscle availability, which significantly affects the energy properties of the muscle, depends on the effectively integrated quota through endogenous synthesis and dietary intake. On average, for a healthy 70 kg man, a requirement of about 2 grams per day was estimated, equal to 1.6% of the total 120 grams available in the body. The need for supplementation depends on the amount of creatine lost in the kidney as creatinine, which tends to increase during physical activity. Several studies have shown that oral creatine supplementation can increase muscle pull by about 20% and significantly affect:
- Improvement in strength and maximum power;
- Improvement of the sub-maximal force;
- Improvement of aerobic performance;
- Reduction of muscle fatigue;
- Improvement of body composition;
and probably also on the athlete's aerobic capacity and on the protection of muscle tissue.
Product Features Cm2 Nitrate - SAN
The product in question, which was created with the aim of decisively improving the athlete's anaerobic abilities, focuses on different metabolic and syneric aspects:
- Improve the hemodynamic characteristics, increasing the level of nitric oxide;
- Energetically support the muscle, increasing the pull of muscle phosphocreatine;
- Improve the body's buffering capacity;
- Reduce to the feeling of fatigue;
- Protect the muscle from oxidative damage induced by intense exercise.
Despite all the assumptions, it becomes somewhat difficult to express a "scientific" opinion, based on experimental data and not on potential and theories, given the absence of studies that attest to the effectiveness of formulations such as creatine nitrate or arginine malate.
Recommended use by the company - Cm2 Nitrate - SAN
It is advisable to take 2 capsules a day when swallowed with plenty of water
Mode of use in sports practice Cm2 Nitrate - SAN
Very difficult to formulate an appropriate dosage, given the absence of studies using this type of supplement.
However, in defining an optimal dosage it must always be considered that this product cannot and should not be used as an arginine, creatine or alanine supplement, as it would be difficult to provide the dosages used in sports.
In general, intake should be preferred on an empty stomach, in order to avoid competitive absorption phenomena, and preferably 60 minutes before training, in order to have maximum availability of the components during training and for a maximum of 4 weeks. Given the absence of comparison terms, it would be preferable to use the quota defined on the label.
Cm2 synergies Nitrate - SAN
Numerous studies have shown that the synergy between arginine and creatine can significantly improve the ergogenic properties of the supplement and significantly increase the maximum strength.
Very interesting is also the simultaneous intake of creatine and beta alanine, documented by various studies that highlight:
- Increased carnosine muscle pull, with better resistance to fatigue;
- Significant increase in body mass, compared to creatine alone;
- Improvement of ventilatory capacities and endurance performance;
However, it must be remembered that all these studies were carried out using creatine monohydrate.
Cm2 Nitrate - SAN side effects
Several studies agree that creatine supplementation is safe in healthy individuals. In particular, studies relating to chronic supplementation (3-5 g / day for one year) and acute (20 g / day for a week) do not show any particular side effects.
However, it should be remembered that ingesting too high or poorly solubilized doses could be accompanied by abdominal cramps, nausea, vomiting and diarrhea, as well as chronic doses, especially if performed concomitantly with high-protein diets could significantly increase renal load.
Finally, even if it does not represent a real side effect, it must be considered that the increase in weight that derives from the accumulation of water inside the cell, could have a negative impact on performance.
Arginine: The most common side effects, recorded in large doses, are vomiting, diarrhea and abdominal cramps at doses above 9 grams per day.
Massive doses, generally higher than 30 g, can originate nephrotoxicity, hypotension and headaches.
Beta-Alanine: Already at doses of 10 mg / kg there may be cases of paresthesia (tingling), skin redness and heat, which become greater by 20mg / kg and severe by 40mg / kg.
The presence of these side effects is attributable to the blood peak that occurs after the administration of Beta alanine; consequently the same effects, although pronounced and dependent dose, tend to resolve quickly.
Precautions for use Cm2 Nitrate - SAN
The product is contraindicated in cases of renal or hepatic disease, cardiovascular disease and / or hypertension, in pregnancy, during lactation and under 12 years and adolescents not yet trained.
In the event of prolonged use (over 6/8 weeks), medical advice is required.
This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Further information on the critical analysis of Cm2 Nitrate - SAN.
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