FINACEA ® Azelaic acid

FINACEA ® is a drug based on Azelaic Acid

THERAPEUTIC GROUP: Anti-acne preparations for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications FINACEA ® Azelaic acid

FINACEA ® is used in the treatment of mild and moderate acne even when characterized by papulo-pustular lesions.

FINACEA ® has also proved effective in treating acne rosacea.

Action mechanism FINACEA ® Azelaic acid

FINACEA ®, a medicinal product used in the treatment of acne, owes its therapeutic efficacy to the presence of Azelaic Acid, the active ingredient whose mechanism of action has not yet been fully clarified.

However, the clinical efficacy of this active ingredient seems to lie in:

normalizing activity the production of sebum and keratin, controlling the proliferative processes of keratinocytes and thus avoiding the classic hyperkeratinization that is observed during acne;
antimicrobial activity, effective against Proprionibacterium acnes, a microbial agent involved in the genesis of vulgar acne and sometimes responsible for the phlogistic evolution of lesions;
antioxidant activity, probably determined by the ability to control the formation of free oxygen radicals and important in limiting the oxidative damage induced by reactive oxygen species.

Following skin application the amount of Azelaic Acid absorbed is minimal and is rapidly eliminated via the urine or through the process of Beta oxidation.

Studies carried out and clinical efficacy

AZELAIC ACID IN NANOPARTICLE

Microsc Microanal. 2013 May 15: 1-10. [Epub ahead of print]

Recent study demonstrating the greater efficacy of Azelaic acid organized in nano particles in the treatment of Acne, thanks to the better pharmacokinetic and pharmacodynamic properties.

RETINOIDS AND AZELAIC ACID IN THE TREATMENT OF ACNE

J Drugs Dermatol. 2013 Apr; 12 (4): 434-7.

Interesting review that evaluates the state of the art on the use of Azelaic Acid and retinoids in the treatment of Acne, observing potential benefits not only in the regression of lesions but also in improving skin appearance.

AZELAIC ACID AND CLINDAMYCIN IN THE TREATMENT OF ACNE VOLGARE

Cutan Ocul Toxicol. 2011 Dec; 30 (4): 286-91. doi: 10.3109 / 15569527.2011.581257. Epub 2011 May 25.

Clinical trial demonstrating that combined Azelaic Acid + Clindamycin therapy may have greater efficacy than monotherapy in the treatment of Acne vulgaris

Method of use and dosage

FINACEA ®

Topical gel with 15% Azelaic acid.

Generally we recommend applying the correct amount of gel directly to the region to be treated twice a day, preferably morning and evening, after thoroughly cleansing the skin.

The treatment, lasting at least 4 weeks, should be constantly supervised by your doctor.

Warnings FINACEA ® Azelaic acid

The presence of benzoic acid among the excipients of FINACEA ® requires the utmost caution in the application of the medicine, given the irritating power towards the eyes and mucous membranes.

It is also advisable to avoid exposure of the treated region to ultraviolet light due to the photosensitising power of Azelaic Acid and its excipients.

Keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of FINACEA ® during pregnancy and in the subsequent period of breastfeeding is generally contraindicated given the absence of studies able to clarify the safety profile of Azelaic acid on the fetus and infant.