drugs

CLARITYN ® - Loratadina

CLARITYN ® is a Loratadine based drug

THERAPEUTIC GROUP: Antihistamine - antagonist H1

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications CLARITYN ® - Loratadine

CLARITYN ® is indicated for the treatment of allergic IgE mediated diseases such as allergic rhinitis to chronic idiopathic urticaria.

CLARITYN ® action mechanism - Loratadine

CLARITYN ® is a medicinal product based on Loratadine, a competitive inhibitor of second-generation H1 receptors, and therefore has better pharmacokinetic and pharmacodynamic characteristics than its predecessors, and more precisely from:

  • poor permeability in the central nervous system, with consequent reduction of potential central side effects, first of all sedation;
  • greater selectivity towards H1 receptors with lower atropine-like effects.

Taken orally it reaches the plasma peak in the following 2-3 hours with therapeutic effects that persist on average 4-6 hours after which, after an intense hepatic metabolism supported by cytochromial enzymes, they are eliminated via the urine.

Well distributed among the various tissues, Loratadine can reduce bronchospasms, improving the respiratory capacity of allergic patients, inhibit the edemigenic action of histamine at the level of cutaneous capillaries by controlling the classic dermatological symptoms present during chronic idiopathic urticaria, controlling the stimulus itchy and smooth intestinal smooth muscle.

Studies carried out and clinical efficacy

LORATADINA AND MOTORE FUNCTION

Clin Neurophysiol. 2012 Apr; 123 (4): 780-6.

Study which, considering the widespread use of antihistamines, evaluates the potential side effects of these and in particular of Loratadine in motor control and in the correct execution of voluntary movements.

THE LORATADINE CARDIOVASCULAR SAFETY

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Dec; 22 (23): 1076-8.

Study that assesses the cardiovascular safety of Loratadine used for a long time for the treatment of allergic rhinitis, confirming its safety when used at the recommended dosages.

THE LORATADINA FOR TOPICAL USE

Drug Dev Ind Pharm. 2009 Aug; 35 (8): 897-903. doi: 10.1080 / 03639040802680289.

Very interesting pharmaceutical study that characterizes new formulations for Loratadine and in particular that in gel for topical use, able to optimize the penetration of the drug at the local level, thus being able to limit the potential systemic side effects.

Method of use and dosage

CLARITYN ®

Loratadine 10 mg tablets;

Effervescent tablets of 10 mg of Loratadine;

Loratadine 5 mg syrup per 5 ml of product.

The dosages and timing of the intake of CLARITYN ® must be defined by the physician based on the patient's physiopathological characteristics, his age and above all the severity of the present clinical picture.

Generally in adults, the intake of 10 mg a day of Loratadine is able to guarantee a prompt remission of the complained symptomatology.

Dosage adjustment should be expected in patients with severe impairment of liver function.

Warnings CLARITYN ® - Loratadina

The use of CLARITYN ® must necessarily be preceded by an appropriate medical consultation, useful for verifying the prescriptive appropriateness and the possible presence of contraindications to the use of the drug.

Maximum care should be reserved for patients with severe liver disease due to the significant impairment of metabolic capacity.

CLARITYN ® in tablets contains lactose, therefore its use is contraindicated in patients with lactase enzyme deficiency, glucose-galactose malabsorption syndrome, and galactose intolerance.

In order to obtain adequate results, it is recommended to stop taking antihistamines at least 48 hours before allergy tests.

Keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of CLARITYN ®, in light of the current evidence, should be contraindicated during breastfeeding, given the ability of Loratadine to pass through the breast filter, and limited to cases of real need during pregnancy.

In these latter cases, the supervision of your gynecologist is clearly necessary.

Interactions

The hepatic metabolism to which Loratadine is subjected significantly increases the risk of drug interactions with active ingredients capable of modulating the activity of cytochromial enzymes.

Such interactions could alter the pharmacokinetic characteristics of Loratadine, sometimes making its intake also dangerous.

Likewise, Loratadine induces the activity of hepatic microsomal enzymes, accelerating the catabolism of numerous active ingredients.

Contraindications CLARITYN ® - Loratadine

The use of CLARITYN ® is contraindicated in case of hypersensitivity to the active ingredient or to one of its excipients or to other structurally related molecules.

Undesirable effects - Side effects

Although Loratadine does not cross the blood-brain barrier acting at the nervous level, the use of CLARITYN ® could lead to dizziness, headache, tachycardia, nausea, dry mouth, abnormal liver function and adverse reactions to hypersensitivity to the active ingredient.

Note

CLARITYN ® is a prescription-only drug.