GLIPRESSIN ® is a drug based on Terlipressin
THERAPEUTIC GROUP: Hormones of the posterior pituitary lobe
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effectsDirections GLIPRESSINA ® - Terlipressina
GLIPRESSIN ® is used in the prevention and treatment of bleeding esophageal varices.
Mechanism of action GLIPRESSIN ® - Terlipressin
Terlipressin, the active ingredient of GLIPRESSIN ® is a synthetic analogue of vasopressin characterized by the addition of three glycine molecules on the terminal side of the protein.
This small structural variation gives the terlipressin a particular mode of action, which allows the active ingredient to gradually free itself from the amino acid tail, exerting a predominantly vasoconstrictor rather than an antidiuretic action.
The aforementioned biological property, concentrated above all on the splanchnic level, reduces the blood flow entering the portal vein, reducing the portal pressure, therefore backwards that in force inside the esophageal varices, counteracting bleeding without affecting the hemocoagulative dynamics.
The activity of the terlipressin is also more prolonged than that of its analogue, allowing a duration of action that exceeds 4 hours.
Studies carried out and clinical efficacy
1. TERLIPRESSIN IN THE TREATMENT OF PATIENTS WITH CIRROSES AND REFRACTORY ASCITES
Prospective study that evaluates the efficacy of adding terlipressin to the treatment of cirrhotic patients with refractory ascites and normal renal function. The treatment combined with diuretics and albumin proved to be effective, reducing the degree of ascites by two points, while preserving the patient from potential esophageal bleeding.
2. TERLIPRESSINA / EPINEFRINA IN THE HEART RATE
Emergency medicine that demonstrates how combined adrenaline / terlipressin treatment can be beneficial in the treatment of children with cardiac arrest.
3. CASE REPORT, BLOOD AND EARTHQUAKE
Case report in which an attempt was made to treat an acute prerenal renal insufficiency from gastrointestinal bleeding not responsive to conventional therapy, with terlipressin. Partial results were improved with oral Sildenafil administration.
Method of use and dosage
GLIPRESSIN ® powder and solvent for solution for injection for intravenous use with 1 mg terlipressin acetate :
the need for intravenous administration of the active principle and the surgical field of the pathology require hospital therapeutic intervention.
It will therefore be the duty of the medical specialist to define the appropriate dosage, based on the severity of the bleeding or the preventive aspect.
Warnings GLIPRESSINA ® - Terlipressina
It is useful to remember that treatment with GLIPRESSINE ® is an advanced therapeutic act, which requires continuous supervision of health personnel, within a hospital facility equipped for surgical emergencies.
Blood pressure, heart rate and plasma electrolytes are the main parameters to monitor throughout the treatment.
PREGNANCY AND BREASTFEEDING
The absence of data on the safety of terlipressin on the health of the fetus when taken during pregnancy limits the use of GLIPRESSIN ® both during the gestational period and in the subsequent phase of lactation.
Interactions
Clinically relevant drug interactions capable of varying the pharmacokinetic profile of terlipressin and its biological efficacy are currently unknown.
Contraindications GLIPRESSIN ® - Terlipressin
The use of GLIPRESSIN ® is contraindicated in case of hypersensitivity to the active ingredient, coronary insufficiency, history of myocardial infarction, alterations in heart rhythm, hypertension and during pregnancy and lactation.
Undesirable effects - Side effects
Intravenous administration of GLIPRESSIN ® may be accompanied by side effects such as intense abdominal pain, hypertensive peaks and contraction of diuresis.
Of less clinical interest are cutaneous vasoconstriction, nausea and headache observed following the use of terlipressin.
Note
GLIPRESSINA ® is reserved for use in hospitals.