BUSCOPAN ® is a drug based on joscina N-butyl bromide.
The active ingredient is of vegetable origin, extracted from the Duboisia plant.
THERAPEUTIC GROUP: Spasmolytics
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Indications BUSCOPAN ® Butylscopolamine
BUSCOPAN ® is indicated in the treatment of painful manifestations due to spasms and cramps of the gastro-intestinal and genitourinary tract.
Mechanism of action BUSCOPAN ® Butylscopolamine
The BUSCOPAN ® administered orally or rectally, is absorbed minimally, so that its systemic bioavailability is around 1%. However, this drug tends to concentrate mainly in the anatomical districts in which it exercises its therapeutic action (gastrointestinal tract, gall bladder, hepatobiliary duct, liver and kidney).
BUSCOPAN ® administered at the prescribed doses does not cross the blood-brain barrier, limiting the side effects associated with anticholinergics, and is mostly excreted in the kidney.
The symptomatic action of BUSCOPAN ® is expressed through the competitive action against acetylcholine on muscarinic receptors of the smooth muscles of the gastro-intestinal tract, responsible for excitation and muscle contraction.
Studies carried out and clinical efficacy
This study has shown that the active ingredient of BUSCOPAN ® can exhibit antispastic efficacy at intestinal level about 7 times higher than other spasmolytics. Probably this effect could be associated, as shown by the study conducted on human nerve cells, with the inhibitory effect exerted also on the neuronal nicotinic receptors of the ganglion of the enteric autonomic nervous system, supporting the inhibitory effect on muscarinic receptors of visceral musculature.
This study conducted on 118 patients suffering from irritable bowel syndrome, showed how BUSCOPAN ® administered both in the form of coated tablets and suppositories - determines a significant improvement in intestinal pain and rectal discomfort threshold, especially in patients characterized by predominant diarrhea.
The study shows that the BUSCOPAN ® used on patients suffering from dyspepsia (recurrent pain and discomfort in the stomach), guaranteed an improvement in symptoms in 77% of the cases, thanks to the better gastric distension induced by the drug.
Method of use and dosage
BUSCOPAN ® 10 mg coated tablets: for adults and children over the age of 14, 1 - 2 tablets 3 times a day.
BUSCOPAN ® suppositories of 10 mg: 1 suppository for 3 times a day.
For children under the age of 14, the doctor's instructions must be strictly followed.
Warnings BUSCOPAN ® Butylscopolamine
The use of anticholinergics, therefore of BUSCOPAN ® must be carried out with caution in the elderly, in patients with autonomic nervous system disorders, in cardiac tachyarrhythmias, in arterial hypertension, in congestive heart failure, in hyperthyroidism and in carriers of liver and kidney diseases.
In general, anticholinergics can interfere with normal driving and concentration skills.
Avoid chewing the BUSCOPAN ®
PREGNANCY AND BREASTFEEDING
Although no toxic effects occurred during pregnancy and lactation, nor teratogenic or embryotoxic effects on animal guinea pigs, it would be advisable to consult your doctor before taking BUSCOPAN ® in pregnancy, particularly in the first trimester.
Interactions
The BUSCOPAN ® can interfere with:
Tricyclic antidepressants, accentuating their effect.
Dopamine antagonists, reducing the effects of both drugs.
Beta-adrenergic, enhancing the tachycardia effect.
It is recommended not to take antacids and alcohol during the treatment, in order to avoid the metabolism alterations of BUSCOPAN ®
BUSCOPAN ® Butylscopolamine Contraindications
BUSCOPAN ® is contraindicated in case of hypersensitivity to one of its components or metabolites, acute angle glaucoma, prostatic hypertrophy or other causes of urinary retention, pyloric stenosis and other conditions stenosing the gastrointestinal canal, paralytic ileus, ulcerative colitis, megacolon, esophagitis reflux, intestinal atony of the elderly and debilitated subjects, and myasthenia gravis and in children under the age of 6 years.
Undesirable effects - Side effects
Therapeutic doses of BUSCOPAN ® can cause dry mouth, alteration of sweating, alterations of ocular tone, difficulty in urination and drowsiness.
High doses of BUSCOPAN ® can also be associated with tachycardia and alterations in cardiorespiratory function and cognitive abilities.
Skin rashes of various kinds can be associated with hypersensitivity to one of its components.
Note
BUSCOPAN ® is gluten and lactose free.
