ANTIADIPOSO ® Iodiocaseina + Thiamine

ANTIADIPOSO ® a drug based on Iodiocaseina and Thiamine nitrate

THERAPEUTIC GROUP: Iodic therapy

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications ANTIADIPOSO ® Iodiocaseina + Thiamine

ANTIADIPOSO ® is a drug used in the treatment of childhood and adolescent obesity due to metabolic alterations and related pathologies such as simple adiposity, adipose gigantism, microsomal adiposity, pachisomy and micropachisomy.

Mechanism of action ANTIADIPOSO ® Iodiocaseina + Thiamine

ANTIADIPOSO ® is a drug with a complex mode of action, carried out by combining two active ingredients with antagonistic biological properties, which at the same time significantly improve the metabolic capacities of the treated patient, avoiding unpleasant side effects linked to iodinated extract therapy.

More precisely, while the casein iodine acts by increasing the availability of iodine, therefore stimulating the thyroid function and the related metabolic processes downstream, thiamine (vitamin B1), enhancing the oxidative decarboxylation of pyruvate, the degradation of lactic acid and other metabolic pathways intermediates should restore the enzyme balance disturbed by increased thyroid activity.

Despite this, the very high iodine content (about 60 times higher than the recommended dose), and the high number of thyrotoxicosis and hyperthyroidism episodes associated with ANTIADIPOSO ® therapy prompted the EMEA to revoke the authorization for entry into trade in this medicine.

Consequently, as early as 22 October 2009, the ANTIADIPOSO ® drug is no longer marketable on the whole European territory.

Studies carried out and clinical efficacy

1. DRUGS AND OBESITY

Work that precedes the times questioning the real need for drug treatment in obesity. Among the drugs considered there is in addition to the orlistat also ANTIADIPOSO, for which we try to understand the real benefits and potential side effects. Time gave reason to the author in the need to carefully assess the extent of adverse reactions that could seriously compromise the patient's state of health.

2. SIDE EFFECTS OF IODIOCASEINE

Case report, example of the important side effects described following the prolonged administration of iodiocasein and which led the EMEA to revoke the marketing authorization. The patient in question has developed tachycardia, dyspnea, headache, myocarditis and pericarditis fortunately returned after the therapy was suspended.

3. THERAPEUTIC ROLE OF IODIOCASEINE

Study showing the efficacy of iodiocasein in the prophylaxis of iodine deficiency and subsequent hypothyroidism. This study shows that the drug in question can be useful and safe in the therapeutic treatment of iodine deficiency and less in the treatment of adiposity.

Method of use and dosage

ANTIADIPOSO ® 125 mg iodine tablets (7.6% iodiocaseina) and 12.33 mg thiamine nitrate (equivalent to 10 mg of thiamine):

the recommended dosage should be closely related to the patient's ability to respond, considering a maximum loss of 250 grams per week with the administration of 1 tablet per day.

Medical monitoring throughout the treatment plan is of fundamental importance.

The aforementioned indication has exclusively cognitive value, given the suspension of the marketing of ANTIADIPOSO ®

Warnings ANTIADIPOSO ® Iodiocaseina + Thiamine

Both before and during therapy with ANTIADIPOSO ® it is important that the doctor carefully and continuously assess thyroid, cardio-circulatory, hepatic and respiratory function providing immediate suspension of therapy in the event of changes in normal function.

ANTIADIPOSO ® tablets contain sucrose and are therefore contraindicated in patients who are intolerant to fructose or who suffer from glucose / galactose malabsorption syndrome or sucrase / isomaltase enzyme deficiency.

The strong risk of thyrotoxicosis and hyperthyroidism has prompted international agencies to suspend the marketing of this product throughout Europe.

PREGNANCY AND BREASTFEEDING

The potential toxic effects on the mother's health and the absence of significant clinical studies, useful for evaluating the safety profile of ANTIADIPOSO ® on the health of the fetus and infant, do not allow the use of this medicine during the period of pregnancy and lactation, making it strongly contraindicated.

Interactions

The administration of drugs containing iodine or capable of acting on thyroid function may compromise the therapeutic effects of ANTIADIPOSO ®

Contraindications ANTIADIPOSO ® Iodiocaseina + Thiamine

ANTIADIPOSO ® is contraindicated in cases of hyperthyroidism, renal lesions, tuberculosis and severe lung diseases, heart disease, liver and adrenal insufficiency.

This medicine is also contraindicated in case of hypersensitivity to one of its components and during the period of pregnancy and lactation.

Undesirable effects - Side effects

In addition to the presence of possible allergic reactions, manifested by dermatological and systemic reactions, the use of ANTIADIPOSO ® may be related to alterations in taste, salivation, development of eye diseases and bronchitis.

Prolonged use or high doses can cause hyperthyroidism and thyrotoxicosis with associated symptoms such as: headache, insomnia, tachycardia, arrhythmias, agitation, nervousness, tremors and more rarely hypothyroidism.

These latter adverse reactions have been the basis for the revocation of the marketing of this product.