Information on Strato GH - KEFORMA
GH layer - KEFORMA
Food supplement based on Arginine aspartate and Ornithine alpha keto-glutarate
FORMAT
60 cps bottle
COMPOSITION
Arginine aspartate
Ornithine alpha keto-glutarate (OKG)
Vitamin B6
Capsule: edible gelatin
One dose (four capsules) contains: Arginine aspartate 2.6 gr
OKG 1.4gr
Vitamin B6 2.4 mg
It is then introduced through the diet, being abundant in peanuts, meats and legumes. After ingestion it is absorbed in the intestine and distributed in the various tissues, with particular importance in the liver, where it allows the advancement of the urea cycle, with consequent detoxification from the ammonia derived from the common process of oxidation of the amino acids.
Arginine is also included in many other biological reactions and, through the formation of numerous metabolites, plays an important role in the regulation of the immune response, cell replication, hormonal response and protein synthesis.
For this reason arginine has found different applications in the therapeutic field, supported by different studies, and in the sports field.
In common sporting practice, in fact, supplements based on arginine are used to stimulate the synthesis of nitric oxide, thus improving muscle vascularization and the consequent supply of oxygen and nutrients, and to increase creatine synthesis and enhance GH release.
As can be seen later in the text, there is an important debate regarding the above mentioned effects of arginine.
Ornithine alpha keto-glutarate (OKG): synthetic product consisting of the union of two ornithine molecules through an alpha keto-glutarate bridge.
Ornithine, produced in our body following the action of the enzyme arginase which breaks down arginine into urea, represents the starting point of the urea cycle, thus returning on the one hand to the detoxification of amino residues derived from oxidation of amino acids, and on the other in arginine regeneration.
The effects related to supplementation with this molecule are not yet well documented, and are mainly directed towards supporting protein synthesis in models and patients subjected to burns and trauma. Moreover, some studies show that the ability of this molecule to support the production of nitric oxide (although the mechanism is still unknown), and in increasing insulin secretion in a glucose-dependent manner (probably due to the gluconeogenic role of alpha keto -glutarato). However the role ascertained by several studies is to increase the synthesis of arginine, proline and polyamines, facilitating muscle recovery from severe traumas such as fractures and burns. There are no studies in the literature concerning the application of OKG in sports.
Vitamin B6: introduced in the form of pyridoxine, very present in meat, wholegrain products, liver, fish, egg whites, corn, milk, fruit, green vegetables, brewer's yeast and wheat germ oil, pyridoxine is absorbed in the intestine and from there reaches the liver where it is stored.
Its biological activity is carried out in the phosphorylated form, pyridoxal phosphate, and is part of amino acid metabolism, lipid metabolism, the synthesis of various neutrasmeters, glycogenolysis and gluconeogenesis, nucleotide synthesis and homocysteine detoxification.
Its supplementation has been successfully performed proving to be effective in improving cognitive, metabolic and immune abilities.
Its daily requirement is around 1 / 1.5 mg, but even in this case the cases of deficiency are very rare. Massive doses of this vitamin (over 50 mg / day) can cause peripheral neuropathies.
Use in sports - Strato GH - KEFORMA
Like the supplements described in this section, the results sought by its use in sports are related to the increase in lean mass, the increase in GH secretion, the improvement in athletic performance.
Product features GH layer - KEFORMA
The product in question combines vitamin B6 and OKG with arginine. Certainly one of the goals of this synergy is to support the correct amino acid metabolism, increasing protein synthesis and regularizing ammonia detoxification.
Definitely, as can easily be deduced from the name, this supplement also aims at increasing the secretion of growth hormone, but the data obtained from the scientific world seem somewhat contradictory.
Rationale for use - Strato GH - KEFORMA
Although a recent study has shown an increase in GH in 9 athletes subjected to integration for three weeks of arginine and ornithine, the scientific world seems to agree on the absence of the stimulatory effect on GH secretion, both by ornithine and arginine, in healthy individuals and subjected to physical exercise.
Common practice, but nevertheless wrong, is to generalize the results obtained on guinea pigs or on individuals suffering from particular pathologies or on intravenous administrations at very high concentrations, extending them to the sports world. This was done with OKG, for which no study on healthy individuals and / or athletes has yet been documented.
Several studies, on the other hand, seem to agree on the increase of muscular energy capacities, on preserving amino acids from oxidation and on improving athletic performance, all benefits that would derive from arginine supplementation especially if associated with BCAA and creatine.
Recommended use by the company
Swallow 4 capsules a day.
Use in sports - Strato GH - KEFORMA
Arginine: the various studies carried out on athletes use quite various dosages, from 2 to 8 grams per day (best results obtained at dosages of 3 gr / day), to improve physical performance and reduce the feeling of fatigue.
The dosages used to increase GH secretion are generally higher and can even reach up to 15 grams per day, a dose at which side effects may occur.
Administration on an empty stomach is preferred, to avoid competitive phenomena in intestinal absorption.
Ornithine: studies that show positive effects in reducing lactate following physical exercise, and consequently also the feeling of fatigue, have used dosages of around 2 g / day for at least 7 days.
Side Effects GH Layer - KEFORMA
The most common side effects, recorded in large doses, are vomiting, diarrhea and abdominal cramps at doses above 9 grams per day.
Massive doses, generally higher than 30 g, can originate nephrotoxicity, hypotension and headaches.
Ornithine: doses above 10/20 gr can give rise to gastrointestinal disorders.
Not enough data on OKG.
Precautions for use Strato GH - KEFORMA
The product is contraindicated in cases of renal or hepatic disease, cardiovascular disease and / or hypertension, in pregnancy, during lactation and under 12 years and adolescents not yet trained.
This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Further information on the critical analysis of Strato GH - KEFORMA.
| BIBLIOGRAPHY |
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Failure of commercial oral amino acid supplements to increase serum growth hormone concentrations in male body-builders.Lambert MI, Hefer JA, Millar RP, Macfarlane PW. |
