Carnitine Q10 - Gensan

Information on Carnitine Q10 - Gensan

Food supplement of L-carnitine and Beta Alanine.

FORMAT

Container with 60 capsules

COMPOSITION

L Carnitine Tartrate: salified form with tartaric acid.

Coenzyme Q10

Beta alanine

Chrome orotate

Capsule: Edible gelatin

Dyes: E172, E127, E 17

One dose contains:

L-Carnitine 200 mg - trimethylated amino acid derivative, mainly synthesized in the liver and kidneys from two essential amino acids, such as methionine and lysine. This molecule is able to bind long-chain fatty acids and transport them, through a membrane transporter, into the mitochondrial matrix, where they undergo the oxidative process with energy production.

During physical exercise performed at 50 - 60% of VO2 max, fatty acids are the main energy substrate to support performance; however, the physiological reduction of the levels of non-esterified muscle carnitine, which occurs during the exercise itself, significantly affects the maintenance of oxidative, and therefore aerobic, capacity of the muscle subjected to stress, favoring the increase in glucose metabolism which in turn further inhibits lipid oxidation (reducing the activity of the transporter for acyl carnitine) and causing a reduction in aerobic treshould. A muscle well supplied with carnitine, could therefore better support lipid oxidation, saving muscle glycogen as an energy source. This, however, represents the limiting step of carnitine integration, as the increase in its concentration in the blood - produced by the intake of the supplement - is not accompanied by a significant increase in concentration of muscular carnitine, therefore it does not correspond to a real benefit in physiological terms, given that the biological function of carnitine is carried out precisely at a muscular level.

Coenzyme Q10 20 mg - also known as ubiquinone, plays a key role in the red-ox processes within the cell, also allowing the transport of electrons through the respiratory chain, with consequent production of energy in the presence of oxygen. Partially synthesized endogenously, and partly taken through cereals, soy, vegetables and nuts, given its lipophilicity, it can be easily absorbed in the gastrointestinal tract following a meal rich in lipids and spread just as easily between cell membranes. It is found in various tissues, but mainly in those characterized by an important oxidative metabolism, such as muscles and in particular the heart. Its marked antioxidant and protective properties against the oxidative insult to the various biological structures, and its deficiencies observed in aging and in various pathologies such as cardiovascular, neuronal and metabolic, make coenzyme Q10 one of the most studied and characterized antioxidants in therapeutic treatment. Numerous studies, in fact, show the benefit obtained - following supplementation - on the reduction of oxidative stress in different pathologies, and in particular in the cardiovascular ones.

Given its strong antioxidant role, coenzyme Q10 has also been tested as a supplement for sports use, receiving - scientifically speaking - good success. The numerous studies carried out both on professional athletes and on amateur sportsmen, have shown how the coenzyme Q10 supplementation, generally for at least 2 weeks at doses between 100mg - 300mg, has guaranteed a reduction of the post-workout fatigue sensation, a reduction in markers blood oxidative, an increase in mean strength and a reduction in markers of muscle damage induced by intense physical activity (such as myoglobin and creatinkinase).

Its requirement is around 5mg / day, but it must be considered that this increases up to 50mg / day exceeded 35 years.

Beta Alanine 150 mg - together with L-histidine is part of the synthesis of carnosine by carnosine synthase, representing the limiting factor. The oral intake of this amino acid, in fact, seems to increase the muscular stocks of carnosine by 80%, particularly concentrated in the fast-contraction fibers. This dipeptide acts as an acidosis buffer which is carried out following lactic fermentation during intense physical efforts, and as an antioxidant, proving to be effective in reducing the sensation of fatigue and improving athletic performance. Studies instead show contradictory data regarding the ability to increase muscle strength or improve body composition. Instead, several researches show an important synergy with creatine.

The doses used in the studies, generally, are around 4 - 6 g / day, for about 4 weeks, divided into several doses during the day. However, already at single doses higher than 800mg, phenomena of paresthesia (tingling) are documented, which resolve quickly.

The side effects are dose dependent.

Chromium orotate 200 mcg : chromium bound to the orotic acid, which taking on characteristics of the organic molecule can be more easily absorbed. This element has proved to be very important especially in regulating glucose metabolism, being part of the synthesis of the carbohydrate tolerance factor. It has also been shown to be effective in improving insulin activity in patients with type II diabetes, normalizing blood glucose levels and reducing the risk of associated diseases. However, recent studies on chromium supplementation at 200 mcg for several weeks seem to be disappointing in sports practice. In fact, there has been no improvement in the synthesis and accumulation of muscle glycogen, strength, athletic performance and improvement of glucose metabolism during training. Its daily requirement is estimated at around 50mcg, although studies relating to sports supplementation do not record daily doses below 200 mcg.

Product features Carnitine Q10 - Gensan

This carnitine supplement has capsule sub-forms, with the maximum dosage required by law. In addition to L-carnitine tartrate, the supplement provides chromium orotate at the maximum permitted dosage, Beta Alanine and Coenzyme Q10. Although not scientifically proven, the synergy between Coenzyme Q10, Beta Alanine and L carnitine, could improve the body's antioxidant capacity, and counteract the oxidative damage induced by intense exercise, also favoring the recovery phase.

Recommended use by the company - Carnitine Q10 - Gensan

Take one CPS per day

Mode of use in sports practice Carnitine Q10 - Gensan

In sports practice the intake of L Carnitine can follow different protocols. The most common ones foresee a gradual weekly ascent from 500mg up to 2 / 2.5g per day, while others provide for a descent from 2.5g to 500mg per day. Higher dosages in healthy subjects are not recommended, as the excess product would be excreted intact at renal level.

The optimization of supplementation with L-Carnitine, should include aerobic exercises, able to maintain high pO2 in the muscular level, and possibly a reduction in the glucidic content of the diet

The dosages of the various components, with the exception of chromium, appear however quite low for each capsule, and reach the levels used in the literature only if the typical intake protocol for L-Carnitine is followed. However, in this case the chromium levels could be too high, reduce iron absorption and cause gastro-intestinal problems.

Rationale for use - Carnitine Q10 - Gensan

The scientific literature provides several very contrasting articles, in most negative cases, regarding the terms of improvement of aerobic performance, or the increase in lipid metabolism following supplementation with Carnitine in healthy individuals and athletes.

The antioxidant effects of coenzyme Q10 and beta alanine, both of which are effective in reducing markers of oxidative damage following intense exercise, are demonstrated.

It remains clear that the doses used in the studies far exceed those provided by the single capsule.

Side effects Carnitine Q10 - Gensan

At high doses episodes of insomnia, nausea, abdominal cramps, migraine and gastro intestinal disorders may occur, albeit rare.

Precautions for use Carnitine Q10 - Gensan

Contraindicated in cases of renal, hepatic, diabetic, pregnancy, lactation, mood disorders.

This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Further information on the critical analysis of Carnitine Q10 - Gensan.