NAC, Twinlab - N Acetyl Cysteine

Information about NAC, Twinlab - N Acetyl Cysteine

Food supplement based on N Acetyl Cysteine

FORMAT

60 cps bottle

COMPOSITION

NAC

Thickener: gelatin

Anti-caking agents: Silica and Magnesium stearate

One capsule contains: NAC 600 mg

N-Acetyl Cysteine ​​200mg - acetylated form of the most common cysteine; has significant advantages in terms of bioavailability, compared to the non-acetylated form. The NAC, in fact, is rapidly absorbed after its oral administration, recording a maximum blood peak after 2-3 hours from ingestion with a half-life around 6 hours, contrary to what happens for the non-acetylated form, commonly present in the foods in the form of a dipeptide, which competes with the glutamate receptor.

N acetyl cysteine ​​permeates cells very easily, where deacetylated regenerates L Cysteine.

This sulfur amino acid is the limiting factor in the synthesis of glutathione (gamma glutamyl cysteine ​​glycine), one of the most powerful antioxidants available to us. Therefore the integration of N acetyl cysteine ​​may be useful in cases of glutathione deficiency, taking into account the low bioavailability of this product following oral intake. Supplementation with NAC was very useful in different areas:

1. Drug detoxification (paracetamol);
2. Mucolytic therapy;
3. Nephroprotective and neuroprotective agent;
4. Anti-flu agent;
5. Pulmonary fibrosis therapy;
6. Oxidative stress disorders;
7. Treatment of baldness.

Numerous studies are also evaluating its protective capabilities against degenerative diseases, nutritional metabolic diseases (diabetes), cancer and cocaine addiction.

Applications in sports NAC, Twinlab - N Acetyl Cysteine

In sports, like other antioxidants, it is useful in:

1. Reduce the oxidative damage that occurs following intense physical activity;

and indirectly in:

1. Improve athletic performance;
2. Reduce the feeling of fatigue;
3. Facilitate recovery.

It is ERRONEOUSly believed that NAC can help with weight loss. There is no study in this regard.

Recommended use by the company - NAC, Twinlab - N Acetyl Cysteine

1 cps per day during meals

Use in sports NAC, Twinlab - N Acetyl Cysteine

Various studies have tested the effectiveness of supplementation with NAC in sports practice.

The dosages found in these studies start at 600mg / day and reach 1.2 / 1.8g per day on training days. In the same, the timing of administration varies from 2 to 6 weeks.

Regarding the methods of administration, the oral dose shows a blood peak two / three hours after taking it, so it may be useful to take it in the morning, or adjust its intake relative to the training time, considering the time necessary for 'absorption.

How to optimize its activity - NAC, Twinlab - N Acetyl Cysteine

It would be possible to enhance its antioxidant activity by combining N acetyl cysteine ​​with other compounds with the same role, such as vitamin E, vitamin C, lipoic acid and coenzyme Q10.

Studies are known concerning the effectiveness of antioxidant cocktails in improving athletic performance.

Rationale for use - NAC, Twinlab - N Acetyl Cysteine

Studies show that supplementation with N acetyl cysteine, in healthy individuals subjected to fiscal exercise, can significantly reduce the concentrations of oxidative damage markers following intense physical activity. In fact, there have been 30% reductions in products of oxidative derivation, while the levels of blood glutathione have increased by as much as 31%.

Data on the NAC's ability to reduce the feeling of fatigue and improve athletic performance are contrasting.

Side effects NAC, Twinlab - N Acetyl Cysteine

No particular side effects of oral supplementation with NAC have been recorded, even for prolonged periods. However, strict medical supervision is required in the case of asthmatic individuals, with respiratory tract affections or with diseases of the gastrointestinal tract.

Intake of the product may occasionally be followed by nausea, vomiting or hypersensitivity reactions, such as hives and bronchospasm.

Interactions

may interfere with various types of antibiotics if taken at the same time.

This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Further information on the critical analysis of NAC, Twinlab - N Acetyl Cysteine.

BIBLIOGRAPHY

Am Fam Physician. 2009 Aug 1; 80 (3): 265-9. N-acetylcysteine: multiple clinical applications. Millea PJ. Lipoic acid and N-acetyl cysteine ​​decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G eid MB, Stokic DS, Koch SM, et al. N-Acetylcysteine ​​inhibits muscle fatigue in humans. J Clin Invest. 1994; 94: 2468-2474Matuszczak Y, Farid M, Jones J, et al. Effect of n-acetylcysteine ​​on glutathione oxidation and fatigue during handgrip exercise. Muscle Nerve. 2005; 32: 633-638. doi: 10.1002 / mus.20385. The antioxidant role of glutathione and N-acetyl-cysteine ​​supplements and exercise-induced oxidative stress. Kerksick C, Willoughby D. J Int Soc Sports Nutr. 2005 Dec 9; 2: 38-44. Modulatory effect of N-acetylcysteine ​​on pro-antioxidant status and haematological response in healthy men. Zembron-Lacny A, Slowinska-Lisowska M, Szygula Z, Witkowski Z, Szyszka K. J Physiol Biochem. 2010 Mar 31. [Epub ahead of print] Effects of sulfur-containing compounds on plasma redox status in muscle-damaging exercise. Zembron-Lacny A, Ostapiuk J, Szyszka K. Chin J Physiol. 2009 Oct 31; 52 (5): 289-94. Erratum in: Chin J Physiol. 2009 Dec 31; 52 (6): 455. Chest. 2009 Aug; 136 (2): 381-6. Epub 2009 May 15. Effect of N-acetylcysteine ​​on air trapping in COPD: a randomized placebo-controlled study. Stav D, Raz M. //www.pharmamedix.com/principiovoce.php?pa=Acetilcisteina&vo=Avvertenze Sulfur in human nutrition and applications in medicine. Parcell S. Altern Med Rev. 2002 Feb; 7 (1): 22-44. Review. Lipids Health Dis. 2010 Mar 6; 9: 23. Comparative antilipidemic effect of N-acetylcysteine ​​and sesame oil administration in diet-induced hypercholesterolemic mice. Korou LM, Agrogiannis G, Pantopoulou A, Vlachos IS, Iliopoulos D, Karatzas T, Perrea DN. Neuroprotective effect of N-acetylcysteine ​​in the development of diabetic encephalopathy in streptozotocin-induced diabetes. Kamboj SS, Chopra K, Sandhir R. Metab Brain Dis. 2008 Dec; 23 (4): 427-43. Epub 2008 Sep 19.