What's this
Arginine Piroglutamate is the Piroglutamate salt of the amino acid Arginine.
This salification would improve the central tropism of Arginine and Piroglutamate itself, making it useful in safeguarding some important brain functions.
Indications
Why is Arginine Piroglutamate used? What is it for?
Arginine Piroglutamate - Chemical Structure
Thanks to the better ability of Arginine Piroglutamate, compared to Arginine itself, to cross the blood-brain barrier and reach the central nervous system, Arginine pyroglutamate supplements are mainly used to improve cognitive performance .
Mainly for this reason, the Arginine Piroglutamate is distinguished from the other salts of Arginine, formulated instead to improve the general bioavailability of the Amino acid.
Property and Effectiveness
What benefit has Arginine Piroglutamate shown during the studies?
According to some experts, the supposed central activity of Arginine Piroglutamate derives from the chemical similarity with the piracetam molecule, an active ingredient known for its high neurological tropism.
According to some studies, mostly experimental, the use of Arginine Piroglutamate would protect the central nervous system (especially some higher functions such as memory and reasoning ability), the decline linked to aging or alcohol-induced damage.
Despite some very encouraging works, there is still a lack of particularly significant evidence.
Doses and method of use
How to use Arginine Piroglutamate
The recommended daily dosages of Arginine Piroglutamate are generally between 500 and 1, 000 mg.
The salification of Arginine with Piroglutamate should both improve the intestinal absorption of the active ingredient, and increase its nervous tropism, allowing the Piroglutamate to cross the blood-brain barrier.
Side effects
The use of Arginine pyroglutamate, at the aforesaid dosages, is generally well tolerated and without clinically relevant side effects.
Contraindications
When should the Argogline Piroglumato not be used?
The use of Arginine pyroglutamate is contraindicated in case of hypersensitivity to the active ingredient during pregnancy and breastfeeding and in children.
Pharmacological Interactions
What drugs or foods can modify the effect of Arginine Piroglutamate?
As for L-Arginine, the contextual use of Cyclosporine, Ibuprofen, organic Nitrates, Sildenafil and plant extracts such as Yohimbe, could contribute to the onset of pharmacokinetic and pharmacodynamic changes in the activity of Arginine Piroglutamate.
