TRIATOP ® Ketoconazole

TRIATOP ® is a drug based on Ketoconazole

THERAPEUTIC GROUP: Antifungals for dermatological use - imidazole derivatives

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications TRIATOP ® Ketoconazole

TRIATOP ® is used in the treatment of fungal pathologies of the scalp supported by microorganisms sensitive to Ketoconazole and responsible for itching, dandruff, oiliness and seborrheic dermatitis.

Mechanism of action TRIATOP ® Ketoconazole

TRIATOP ® is a shampoo based on Ketoconazole, therefore indicated for the treatment of scalp infections sustained by dermatophytes, yeasts and fungi responsible for persistent itching, dandruff, oiliness, scaling and seborrheic dermatitis.

The antifungal mechanism is performed through the inhibition of the enzyme 14 alpha-sterol demethylase, involved in the synthesis of? Ergosterol, a key element of the plasma membrane of the microorganism, whose absence reduces its protective and communicative properties.

All this, thanks also to the accumulation of intermediate metabolites interfering with the normal activity of membrane exchange, results in the inhibition of the growth of the fungus and in the prompt regression of the symptomatology in progress.

The absence of systemic absorption of the active principle also allows to considerably limit the possible onset of clinically relevant side effects.

Studies carried out and clinical efficacy

KETOCONAZOLE WITH VARIOUS PERCENTAGES AND CLINICAL EFFICACY

Skin Pharmacol Appl Skin Physiol. 2002 Nov-Dec; 15 (6): 434-41.

Work that compares the clinical effectiveness of various percentages of ketoconazole in shampoos in the treatment of seborrheic dermatitis. Although in all cases an improvement in clinical symptoms has been obtained, 2% Ketoconazole shampoo has generally been more effective.

KETOCONAZOLE IN THE ANDROGENETIC ALOPECIA

Dermatology. 1998; 196 (4): 474-7.

Work that demonstrates how Ketoconazole has a significant anti-inflammatory activity against diseases such as? Androgenetic alopecia regardless of the possible association with Minoxidil.

KETOCONAZOLE IN THE TREATMENT OF SEBORROCIC DERMATITIS

Acta Derm Venereol. 1997 Mar; 77 (2): 132-4.

A dated study that nevertheless demonstrates the effectiveness of the ketoconazole-based shampoo in the treatment of seborrheic dermatitis.

The improvement of the clinical picture was observed in only 4 weeks of treatment.

Method of use and dosage

TRIATOP ®

Topical shampoo for 1% Ketoconazole scalp

We recommend the application of TRIATOP ® on the scalp 2-3 times a week, leaving the drug to work for at least 3-5 minutes.

The duration of the whole treatment could last from 2 to 4 weeks.

Warnings TRIATOP ® Ketoconazole

The presence in TRIATOP ® of excipients such as formaldehyde, lauryl ether sulphate, butylated hydroxytoluene, methyl paraben and propyl paraben could increase the risk of adverse reactions from hypersensitivity, especially following prolonged use of the product.

After the use of TRIATOP ® it is recommended to thoroughly clean the treated area and the parts of the body that have come into contact with the product.

Before using TRIATOP ® it would be advisable in any case to consult your doctor, taking care to delay the use of the drug for at least 2 weeks after systemic or topical intake of corticosteroids.

PREGNANCY AND BREASTFEEDING

Despite the active principle of TRIATOP ® is not absorbed in any way following the topical application of the product, the absence of clinical trials able to fully characterize the safety profile of Ketoconazole for fetal health and of the infant requires strict medical supervision for the possible use of the product during pregnancy and in the subsequent period of breastfeeding.

Interactions

No clinically relevant drug interactions are currently known.

Contraindications TRIATOP ® Ketoconazole

TRIATOP ® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients.

Undesirable effects - Side effects

TRIATOP ® is generally safe and has no clinically relevant side effects.

The only adverse reactions worthy of note, due to the frequency of occurrence, are itching and redness at the site of application, whose remission is however rapid once the application is suspended.