LORENIL ® Fenticonazole

LORENIL ® is a drug based on Fenticonazole nitrate

THERAPEUTIC GROUP: Antimicrobials and antiseptics

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications LORENIL ® Fenticonazole

LORENIL ® is indicated in the treatment of candidiasis of genital mucous membranes.

Mechanism of action LORENIL ® Fenticonazole

Fenticonazole, the active ingredient of LORENIL ®, is an imidazole derivative that has been used for years in the treatment of dermatomycoses and candidiasis of the genital mucosa.

Used topically Fenticonazole is able to easily permeate the plasma membrane of fungal cells, inhibiting the enzyme 14 alpha methyl lanosterol demethylase, and compromising the synthesis of Ergosterol, sterol present in abundance in the plasma membrane and responsible for the chemical properties physical parts of the same.

The reduction on one side of this element and the accumulation of potentially toxic catabolites compromises the vitality of the fungal cell, determining the death of the same and the regression of the symptomatology.

In addition to the antifungal activity, Fenticonazole is also effective against Gram positiv microorganisms, being able to exert a therapeutic action even in bacterial over infections.

Studies carried out and clinical efficacy

FENTICONAZOLE AND VAGINAL CANDIDIASI

J Int Med Res. 1986; 14 (6): 306-10.

Clinical trial demonstrating that the use of Fenticonazole is more effective and better tolerated than that of other antifungals in the treatment of vaginal candidiasis, representing one of the first choice drugs in these situations.

FENTICONAZOLE: POSOLOGICAL SCHEMES

J Int Med Res. 1987 Sep-Oct; 15 (5): 319-25.

Work that demonstrates the effectiveness of the various dosages of Fenticonazole in the treatment of vulvovaginal mycoses, in the face exclusively of an immediate transient burning sensation following its intake.

PHARMACOCINETICS OF FENTICONAZOLE

Int J Clin Pharmacol Ther Toxicol. 1988 Oct; 26 (10): 479-81.

Gorlero F, Sartani A, Cordaro CI, Bertin D, Reschiotto C, De Cecco L.

Study that shows how 3 hours after taking the amount of drug present in the tissue disregards the dose administered; difference that becomes more significant at the twelfth hour, when the daily dose of 1000 mg maintains greater amounts of Fenticonazole in the tissues than in lower dosages.

Method of use and dosage

LORENIL ®

Vaginal soft capsules of 200mg or 600mg of Fenticonazole nitrate.

The intake of LORENIL ® should be prescribed by the doctor based on the clinical condition of the patient and the severity of his clinical picture.

As a general rule it is recommended to take one 200 mg capsule vaginally for 3 days before bedtime, or the 600 mg capsule in a single administration.

Warnings LORENIL ® Fenticonazole

The use of LORENIL ® should be preceded by a careful medical examination in order to clarify the origin of the symptomatology and its prescriptive appropriateness.

LORENIL ® is a drug for vaginal use, therefore it is necessary to respect all the indications for the use of the medicine

Topical use of Fenticonazole, especially when prolonged over time, could cause unpleasant side effects, some of which are hypersensitive.

It is advisable to keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of LORENIL ® in pregnancy should be justified by real clinical needs and only in the cases where the benefits are more significant than the costs.

All treatment must necessarily be supervised by your gynecologist.