ISOTREX® is a drug based on Isotretinonin
THERAPEUTIC GROUP: Anti-acne preparations for topical use
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Indications ISOTREX ® Isotretinoin
ISOTREX® is used to treat mild to moderate acne.
Mechanism of action ISOTREX ® Isotretinoin
The? Isotretinonina, active ingredient of ISOTREX®, is a derivative of the more well-known Tretinonin, an acid form of vitamin A, chemically revised to ensure better control of side effects related to topical use of the drug.
Like its predecessor, Isotretinonin also acts topically by exerting a keratolytic action, controlling sebum production by the sebaceous glands and stimulating epithelial cell proliferation through the control of gene expression.
All the aforementioned activities result in an effective anti-acne activity, oriented to the prevention of cometone inflammation and the subsequent re-epithelialization necessary for the optimization of the cutaneous features of the injured area.
The absence of systemic absorption makes therapy definitely safe, whose side effects remain limited to transient local reactions.
Studies carried out and clinical efficacy
CLINICAL EFFECTIVENESS OF THE ™ ISOTRITIONIN AND DETERMINANTS
Eur J Dermatol. 2013 Jun 24. [Epub ahead of print]
A very interesting study that demonstrates how the clinical efficacy of Isotretinonin in the treatment of acne vulgaris is significantly associated with other characteristics such as the body mass index, the dietary carbohydrate content and the presence / absence of tobacco.
PHARMACOGENOMICS OF? ™ ISOTRETINONIN
Int J Clin Pharmacol Ther. 2013 Jun 19. [Epub ahead of print]
Genomic drug study demonstrating how polymorphisms of the RARA gene can significantly influence the therapeutic efficacy and clinical safety of Isotretinonin therapy.
ABSCESS FROM ISOTRETINONINA
JAMA Dermatol. 2013 Jun 12: 1-2. doi: 10.1001 / jamadermatol.2013.4066. [Epub ahead of print]
Case report demonstrating the appearance of a rare labial abscess, probably also associated with angioedema and mucositis, which appeared following treatment with Isotretinonin.
Method of use and dosage
ISOTREX®
Topical gel with 0.05% Isotretinonin.
It is generally recommended to apply the appropriate amount of gel on the region to be treated, once a day, prolonging the therapy for at least 3 weeks.
Warnings ISOTREX ® Isotretinoin
ISOTREX® therapy should be preceded by a careful visit to dermatology to clarify the nature of the lesions and the consequent prescription appropriateness.
Patients taking Isotretinonin therapy should also take special care with certain rules to limit the incidence of potential side effects such as: avoiding direct exposure of the treated area to sunlight, thoroughly cleanse the hands after applying the gel, avoid contact with the eyes or mucous membranes, avoid ingestion of the drug and immediately inform the doctor when the first adverse reactions appear.
It is also recommended to keep the drug out of the reach of children.
PREGNANCY AND BREASTFEEDING
Previous contraindications to the use of ISOTREX® should also be extended to pregnancy and the subsequent breastfeeding period given the absence of clinical trials able to ascertain the safety of the drug for fetal health.
Interactions
The patient receiving ISOTREX® should avoid the simultaneous intake of cortisone drugs and the application of other topically applied products, especially those with keratolytic activity.
Contraindications ISOTREX ® Isotretinoin
The use of ISOTREX® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients and in patients suffering from dermatological diseases.
Undesirable effects - Side effects
The use of ISOTREX® could determine the appearance of adverse reactions, with greater frequency in patients at risk or in patients subjected to pharmacological treatments prolonged over time.
Among the most frequent side effects, in addition to erythema, irritation and dry skin, burning and painful skin can also appear.
Fortunately, the most clinically relevant events and generally associated with hypersensitivity reactions to the drug are rarer.
Note
ISOTREX® is a prescription-only drug.
