DIFFERIN ® Adapalene

DIFFERIN ® is a drug based on Adapalene

THERAPEUTIC GROUP: Anti-acne preparations for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications DIFFERIN ® Adapalene

DIFFERIN® is indicated in the treatment of acne vulgaris in all its manifestations.

Mechanism of action DIFFERIN ® Adapalene

DIFFERIN ® is a medicinal product based on Adapalene, a third generation retinoid widely used in the treatment of acne.

Comedolotic and keratolytic activity is due to the ability to selectively bind the retinoic acid nuclear receptor, modulating gene expression in an anti-inflammatory and anti-proliferative sense.

The anti-inflammatory stimulus on the one hand and the control of the proliferation of keratinocytes on the other allow an effective control of the evolution in an inflammatory sense of the skin lesion, thus allowing a clear improvement in the quality of the skin and normalizing the production of keratin so as to limit the typical hyperkeratinization of acne pathology.

The aforementioned mechanisms, also supported by the control of inflammatory chemotaxis, are sustained by the good pharmacokinetic properties that reduce the absorption of topically applied Adapalene to a minimum, thus reducing the potential systemic side effects.

Studies carried out and clinical efficacy

TOLERABILITY AND EFFECTIVENESS OF ADAPALENE

J Cosmet Dermatol. 2013 Jun; 12 (2): 103-7. doi: 10.1111 / jocd.12031.

An interesting study that shows how the treatment of acne with Adapalene or Tretionine produces the same therapeutic effect, although the first active ingredient is better tolerated than Tretionine in Mexican patients.

SEBOSTATIC ACTIVITY OF ADAPALENE

J Dermatol Sci. 2013 Jun; 70 (3): 204-10. doi: 10.1016 / j.jdermsci.2013.02.003. Epub 2013 Feb 14.

Experimental study that demonstrates how Adapalene can contribute to the improvement of acne lesions, also guaranteeing better control over sebum production, probably through the control of local triglyceride synthesis

ADAPALENE vs BENZOYL PEROXIDE / CLINDAMYCIN

J Drugs Dermatol. 2012 Jun; 11 (6): 714-22.

Study demonstrating how the association of Benzoyl peroxide and Clindamycin can guarantee an improvement in the quality of life of patients suffering from acne faster than the Adapalene, although safety and tolerability are similar.

Method of use and dosage

DIFFERIN ®

Gel and cream for topical use at 0.1% of Adapalene

Generally, it is recommended to apply the appropriate amount of cream or gel directly on the affected region, once it has been cleaned, once a day, taking care to gently massage the area to ensure complete absorption.

Warnings DIFFERIN ® Adapalene

In order to optimize therapeutic efficacy, reducing the potential side effects of therapy, it would be appropriate:

avoid direct contact with eyes and mucous membranes;
thoroughly clean your hands after applying the drug;
avoid exposure of the treated area to sunlight;
avoid application of the medicine on damaged or affected skin.

It is recommended to store the drug in a cool, dry place out of reach of children.

PREGNANCY AND BREASTFEEDING

Given the lack of studies able to better characterize the safety profile of the Adapalene for fetal and infant health, it is advisable to extend the contraindications to the use of DIFFERIN ® also to pregnancy and the subsequent period of breastfeeding at otherwise.