Category pharmacology

Tolerance and Resistance to Drugs: What They Are and How they are Established by I.Randi
pharmacology

Tolerance and Resistance to Drugs: What They Are and How they are Established by I.Randi

Generality Tolerance and resistance to drugs are different phenomena but they share the decrease of the therapeutic effect of a given drug. While tolerance develops in the patient who takes the drug, drug resistance normally refers to an insensitivity that develops in pathogenic microorganisms (such as, for example, bacteria and viruses) and in cancer cells, respectively, of anti-infective drugs (antibiotics)

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pharmacology

Tachyphylaxis: What is it? When and how is it manifested? Characteristics and Causes of I.Randi

Introduction Tachyphylaxis is a particular type of tolerance that develops against drugs or other substances. Therefore, since it is a form of tolerance, the onset of tachyphylaxis involves a reduction in the body 's sensitivity to a specific drug or to a specific toxic substance. There are basically two different forms of tolerance: chronic tolerance and tachyphylaxis , also known as acute tolerance or short-term tolerance
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pharmacology

Tolerance and Resistance to Drugs: What They Are and How they are Established by I.Randi

Generality Tolerance and resistance to drugs are different phenomena but they share the decrease of the therapeutic effect of a given drug. While tolerance develops in the patient who takes the drug, drug resistance normally refers to an insensitivity that develops in pathogenic microorganisms (such as, for example, bacteria and viruses) and in cancer cells, respectively, of anti-infective drugs (antibiotics)
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pharmacology

Intrathecal administration

Generality The intrathecal route of administration is a particular type of parenteral administration, which consists in injecting the drug directly into the spinal fluid. In this way, it is possible to administer the desired active ingredient near the receptors present at the spinal level, with which it must interact to obtain the desired therapeutic action
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pharmacology

Transdermal patches: tank and matrix

A transdermal patch is normally composed of an external protective layer, an intermediate zone containing the active ingredient and an adhesive that ensures the contact of the preparation with the skin. The external protective layer has the function of supporting and protecting the device and, normally, it is impermeable to drugs and water
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pharmacology

Transdermal patches: what to do when an irritation appears

In some cases, medicated patches can cause skin irritation . These phenomena occur especially in people who have very sensitive skin: the treated area may redden, itch or become covered with vesicles full of serum. This side effect could only depend on the application of the patches . In this case, it is sufficient to pay more attention during the handling and positioning of the product (the package insert attached to the drug indicates precisely how and where to make the patch adhere to the skin)
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pharmacology

What are the advantages of transdermal patches?

Compared to drugs taken by mouth or by injection, transdermal administration has several advantages. The transdermal pathway allows regular contributions of the active principle for a prolonged and constant period, without significant variations; the plasma concentration of tablets and tablets follows, instead, a bell curve
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