OLUX ® Clobetasol

OLUX ® is a Clobetasol proprionate based drug

THERAPEUTIC GROUP: Non-associated corticosteroids for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications OLUX ® Clobetasol

OLUX ® is indicated in the treatment of scalp dermatoses generally not responsive to therapies with other corticosteroids.

Mechanism of action OLUX ® Clobetasol

Clobetasol proprionate, active ingredient of OLUX ®, is a corticosteroid belonging to the fourth group, and therefore defined as very powerful, with effective therapeutic activities and well characterized pharmacokinetic properties. In fact following topical application, part of this active principle, unfortunately variable from individual to individual, is absorbed and subjected to the normal processes of hepatic and biliary disposal. The remaining portion, on the other hand, carries out its therapeutic activity on site, with the typical mechanisms of corticosteroids, which include the induction of the expression of Lipocortin, a phospholipase A2 inhibitory protein, an enzyme that initiates the cascade of events leading to the synthesis of phlogosis mediators . This complex molecular mechanism of action is concretized with a clear improvement of the complained symptomatology thanks to the antiedemigina, anti-inflammatory and antipruriginosa action exerted by the Clobetasol.

Studies carried out and clinical efficacy

CLOBETASOL IN THE TREATMENT OF VITILIGINE Dermatol Ther (Heidelb). 2013 Jun 4; 3 (1): 95-105. doi: 10.1007 / s13555-013-0028-8. Print 2013 Jun.

Study that demonstrates how Clobetasol-based skin foam can be a valid therapeutic option for the treatment of vitiligo, significantly improving the cutaneous appearance of the treated region.

NEUROPSYCHIATRIC DISORDERS FROM CLOBETASOLE Therapie. 2013 May-Jun; 68 (3): 179-81. doi: 10.2515 / therapie / 2013026. Epub 2013 Jul 26.

French case report that denounces the appearance of neuropsychiatric disorders following the abuse of Clobetasol propionate, thus underlining the seriousness of the side effects sustained by the share of active principle absorbed systemically.

CLOBETASOL AND HAND DERMATITIS J Drugs Dermatol. 2013 Mar; 12 (3): 328-34.

Clinical trial that demonstrates the effectiveness of Clobetasol-based foam in the treatment of chronic dermatitis of the hands, often responsible for serious social problems and a marked deterioration in the quality of life of affected patients.

Method of use and dosage

OLUX ® 500 mcg dermal foam of Clobetasol propinated for grams of foam. Given the potency of Clobetasol and the significant systemic absorption associated with topical therapy, dosages and timing of intake should be defined by the physician based on the clinical characteristics of the patient and the therapeutic goals to be achieved. In adults, generally, 2 applications per day of the appropriate amount of medicine are recommended directly on the region affected by the injurious process.

Warnings OLUX ® Clobetasol

The use of OLUX ® must necessarily be preceded by a careful medical examination and supervised by medical personnel given the potential biological effects of systemically absorbed Clobetasol. In fact, studies show that the proportion of the absorbed active principle can cause an inhibition, due to transient and immediately reversible luck, of adrenal function, thus altering the normal balance of the hypothalamic-pituitary-adrenal axis. It is also important to reiterate the importance of compliance with the appropriate sanitary regulations concerning the use of OLUX ® in order to limit the incidence of potential side effects and to optimize the effectiveness of the therapy.

PREGNANCY AND BREASTFEEDING

The systemic absorption of Clobetasol extends the contraindications to the use of OLUX ® also to pregnancy and the subsequent period of breastfeeding given the documented mutagenic and toxic effects of Clobetasol for the health of the fetus and infant.

Interactions

At the present time, known pharmacological interactions are not known, although it should be remembered that the simultaneous intake of cytochrome inhibitor drugs may increase blood concentrations of the amount of corticosteroid absorbed.

Contraindications OLUX ® Clobetasol

The use of OLUX ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients, in patients suffering from inadequately treated viral, bacterial and fungal infections, atopic dermatitis, acne vulgaris, rosacea, burns and perianal and genital itching . The use of OLUX ® is also contraindicated in pediatric patients.

Undesirable effects - Side effects

The use of OLUX ®, especially when continued for a long time, could determine the onset of local side effects such as redness, burning, erythema, dermatitis, hypertrichosis, skin discoloration, skin atrophy and telangiectasias. Also not to be underestimated are the side effects related to the systemic absorption of the drug such as inhibition of adrenal activity and changes in blood chemistry tests.