FOLIANS ® Finasteride

FOLIANS ® is a drug based on Finasteride

THERAPEUTIC GROUP: Other dermatological preparations

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications FOLIANS ® Finasteride

FOLIANS ® is indicated in the treatment of androgenetic alopecia in men, particularly in the early states of the disease.

Mechanism of action FOLIANS ® Finasteride

FOLIANS ® is a medicinal product based on Finasteride, a highly bioavailable active ingredient after oral administration which, once absorbed through the enteric circle, reaches the various tissues, carrying out its biological activity, at the end of which following an intense hepatic metabolism supported by cytochromial enzymes it is eliminated through feces and urine.

Its effectiveness in action is linked to the ability to actively inhibit the second type of alpha reductase enzyme, an enzyme that is present in hair follicles and is capable of enzymatically converting testosterone into the relative androgen dihydrotestosterone, which is also responsible for miniaturization. of the hair follicles of the scalp, thus making the baldness irreversible.

Clinical trials show that a well-made therapy based on Finasteride can both limit hair loss and facilitate the growth of new ones, significantly improving the aesthetic appearance of baldness.

Studies carried out and clinical efficacy

THE FINASTERIDE IN PATIENTS WITH INFERTILITY

Fertil Steril. 2013 Sep 4. pii: S0015-0282 (13) 02786-6. doi: 10.1016 / j.fertnstert.2013.07.2000.

Very important study that demonstrates how the treatment with Finasteride in patients with infertility problems can further reduce the sperm count, without however altering the motility or the hormonal framework.

FINASTERIDE AND SEXUAL SPHERE

J Sex Med. 2012 Nov; 9 (11): 2927-32. doi: 10.1111 / j.1743-6109.2012.02846.x. Epub 2012 Jul 12.

Study that describes the potential side effects of Finasteride on the sexual sphere of patients in therapy, demonstrating how this treatment can cause a decrease in libido accompanied by erectile dysfunction even several months after drug withdrawal.

PROSTATE CANCER AND FINASTERIS: investigation methods

Urology. 2013 Sep 19. pii: S0090-4295 (13) 00964-3.

Very interesting study that evaluates the association between increase in prostate volume and prostate cancer in patients undergoing Finasteride treatment, once again highlighting the importance of PSA as a large-scale screening marker.

Method of use and dosage

FOLIANS ®

Finasteride 1 mg tablets

Treatment, generally characterized by taking one tablet a day, must necessarily be defined and supervised by a doctor competent in the treatment of baldness, thus evaluating both the benefits and the potential side effects.

Warnings FOLIANS ® Finasteride

FOLIANS ® therapy must be supervised by your doctor in order to adequately assess all the possible risks associated with the administration of Finasteride.

At the same time the patient must remember that the effects of the drug are not immediate, generally requiring several months before observing any benefits, neither irreversible.

Particular caution in the use of FOLIANS ® should be given in patients with impaired liver function or infertility.

FOLIANS ® contains among its excipients Lactose, thus being generally contraindicated in patients with galactose intolerance, lactase enzyme deficiency or glucose-galactose malabsorption syndrome.

PREGNANCY AND BREASTFEEDING

The use of FOLIANS ® is strictly contraindicated in case of pregnancy or in the subsequent period of breastfeeding, given the importance of dihydrotestosterone in the development of the genital apparatus of the unborn child.

Interactions

In light of the hepatic metabolism of Finasteride, it is necessary to consider how potential inducers or inhibitors of the cytochromial system can alter the normal pharmacokinetic properties of the aforementioned active principle.

Contraindications FOLIANS ® Finasteride

The use of FOLIANS ® is contraindicated in patients hypersensitive to the active ingredient or to one of its excipients and in women.

Undesirable effects - Side effects

The use of FOLIANS ®, even in rare cases, could lead to the appearance of adverse reactions such as hypertransaminasemia, decreased libido, erectile dysfunction, changes in the volume and quality of the ejaculate and even more rarely adverse reactions from hypersensitivity.