NADIXA ® Nadifloxacin

NADIXA ® is a drug based on Nadifloxacin

THERAPEUTIC GROUP: Anti-acne preparations for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions NADIXA ® Nadifloxacin

NADIXA ® is indicated in the treatment of acne characterized by mild and modest inflammatory lesions.

Mechanism of action NADIXA ® Nadifloxacin

NADIXA ® is a drug based on Nadifloxacin, an antibiotic belonging to the category of synthetic quinolones, and therefore has bactericidal activity against Gram positive and negative bacteria, both aerobic and anaerobic.

The aforementioned mechanism of action is carried out through the inhibition of enzymes involved in DNA replication such as Dna girasi and Dna topoisomerase IV, thus causing a total blockage of the proliferative processes of the microorganism.

Efficacy in the treatment of acne derives from the ability of Nadifloxacin to limit the proliferation of microbial strains involved in the pathogenesis of this disease such as Proprionibacterium acnes and Staphylococcus epidermis, and often responsible for its inflammatory complications.

Although the drug is used topically, it is possible that there is a partial systemic absorption of the drug due to the compromised integrity of the stratum corneum under such conditions, which fortunately does not represent a clinically relevant problem.

Studies carried out and clinical efficacy

NADIFLOXACINE IN THE TREATMENT OF ACNE IN COMBINED WITH ADAPALENE

J Dermatol. 2013 Jun 3. doi: 10.1111 / 1346-8138.12189. [Epub ahead of print]

Clinical trial demonstrating that the addition of Nadifloxacin to Adapalene can significantly improve therapeutic results in patients with acne with medium-sized inflammatory lesions.

NADIFLOXACINE, NOT ONLY ANTIBIOTIC ACTIVITY

J Dermatol. 2012 Sep; 39 (9): 774-80. doi: 10.1111 / j.1346-8138.2012.01525.x. Epub 2012 Mar 6.

An experimental study that demonstrates how Nadifloxacin, in addition to determining an antibacterial therapeutic action, can also perform a sebostatic and anti-inflammatory action, thus contributing to the improvement of the patient's clinical conditions.

NADIFLOXACINE AND ACNE

Int J Dermatol. 2011 Mar; 50 (3): 350-7. doi: 10.1111 / j.1365-4632.2010.04701.x.

Clinical trial that shows how 1% Nadifloxacin creams can determine a prompt remission of the symptoms present in patients with Acne, even when complicated by inflammatory lesions.

Method of use and dosage

NADIXA ®

Nadifloxacina dermatological cream of 10 mg per gram of cream.

Usually the therapeutic protocol with NADIXA ® involves the application of the correct amount of cream directly on the skin lesions twice a day, morning and evening.

It would be necessary to thoroughly cleanse the area before applying the medicine.

The duration of treatment should not exceed 8 weeks.

Warnings NADIXA ® Nadifloxacin

In order to optimize the therapeutic efficacy of the drug and limit the potential side effects, the patient receiving NADIXA ® should

cleanse the region to be treated before applying the cream;
avoid contact of the cream with eyes and mucous membranes;
avoid exposure of the treated area to sunlight;
avoid the application of cutaneous regions affected by other pathological processes;
consider the presence of excipients with irritant and allergenic power.

It is also recommended to keep the medicine in a cool and dry place, out of reach of children.

PREGNANCY AND BREASTFEEDING

The aforementioned contraindications also extend to pregnancy and the subsequent breastfeeding period given the absence of studies able to better characterize the safety profile of the drug for fetal health and the ability of Nadifloxacin to be excreted in breast milk .

Interactions

The patient receiving NADIXA ® should avoid topical application of other drugs.

Contraindications NADIXA ® Nadifloxacin

The use of NADIXA ® is contraindicated in patients hypersensitive to the active ingredient or to one of its excipients and in patients suffering from dermatological diseases.

Undesirable effects - Side effects

NADIXA ® therapy may expose the patient to the risk of local and transient adverse reactions such as itching. redness and only rarely urticaria or erythema.