TRAVOGEN ® - Isoconazole nitrate

TRAVOGEN ® is a drug based on Isoconazole nitrate

THERAPEUTIC GROUP: Antimicrobials and antiseptics

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications TRAVOGEN ® - Isoconazole nitrate

TRAVOGEN ® is indicated in the treatment of superficial dermatomycoses and mycotic vulvovaginal infections even when complicated by bacterial superinfections, sustained by microorganisms sensitive to Isoconazole.

Mechanism of action TRAVOGEN ® - Isoconazole nitrate

Isoconazole, the active ingredient of TRAVOGEN ®, is an imidazole derivative widely used in clinical settings for the broad spectrum of direct action not only against dermatophytes, fungi and yeasts but also towards Gram positive and Gram negative microorganisms.

Its therapeutic efficacy is due to its ability to inhibit the enzyme 14 alpha methyl lanosterol demethylase involved in the synthesis of an important membrane element known as Ergosterol.

The absence of this element, which is important in structuring the plasma membrane by regulating the exchanges with the outside, and the accumulation of catabolites toxic to the micro-organism, significantly compromise the viability of the pathogen, determining its death in a few days of treatment.

The aforementioned biological activities are also aided by good pharmacokinetic properties which, by limiting the systemic absorption of the drug, following topical use, significantly reduce the risk of clinically relevant side effects.

Studies carried out and clinical efficacy

ISOCONAZOLE IN THE TREATMENT OF INTERTRIGINE

Mycoses. 2013 May; 56 Suppl 1: 41-3. doi: 10.1111 / myc.12058.

Recent clinical case that demonstrates the efficacy of Isoconazole in reducing itching and improving the cutaneous state of the lesion in a 43-year-old patient with intertrigo supported by Candida Albicans in a few days of treatment.

ANTIBACTERIAL ACTIVITY OF ISOCONAZOLE

Mycoses. 2013 May; 56 Suppl 1: 16-22. doi: 10.1111 / myc.12055.

Molecular study that seeks to characterize the therapeutic role of Isoconazole in the treatment of bacterial over infections, hypothesizing a dependent ROS mechanism of action.

ISOCONAZOLE PHARMACOCINETICS

Eur J Pharm Biopharm. 2012 Apr; 80 (3): 615-20. doi: 10.1016 / j.ejpb.2011.12.013. Epub 2012 Jan 21.

A study that seeks to characterize the pharmacokinetic properties of Isoconazole used topically, and in particular the ability to penetrate the stratum corneum, and into the hair follicle, thus enabling pharmaceutical strategies to optimize the half-life.

Method of use and dosage

TRAVOGEN ®

Dermatological cream with 1% Isoconazole nitrate.

Cream for topical vaginal use with 1% Isoconazole nitrate.

The choice of the pharmaceutical format and the therapeutic scheme is up to the doctor based on the clinical conditions complained by the patient.

It is generally recommended to apply the cream for dermatological use twice a day for two to three weeks, even after the symptoms have disappeared, once a day for a week instead if for gynecological use.

Warnings TRAVOGEN ® - Isoconazole nitrate

The use of TRAVOGEN ® should be accompanied by compliance with some sanitary regulations useful for optimizing the therapeutic efficacy of the treatment, limiting the side effects.

The use of sterile towels, thorough cleansing of the hands before and after treatment, compliance with medical indications are only the main precautions that the patient receiving TRAVOGEN ® should observe to contain side effects and maximize therapeutic efficacy

It is advisable to keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of TRAVOGEN ® during pregnancy and in the subsequent period of breastfeeding should take place under the strict supervision of your doctor and in case of real need.

Interactions

Drug interactions worthy of clinical note are currently unknown.

Contraindications TRAVOGEN ® - Isoconazole nitrate

The use of TRAVOGEN ® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients.

Undesirable effects - Side effects

The use of TRAVOGEN ® is generally well tolerated and has no clinically relevant side effects, although sometimes the patient may complain of symptoms such as local burning, local irritation and vaginal cramps following the use of TRAVOGEN ® gynecological cream.