PASTA LASSAR ® Salicylic acid + zinc oxide

PASTA LASSAR ® is a drug based on salicylic acid and zinc oxide.

THERAPEUTIC GROUP: Emollients and protective agents

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications PASTA LASSAR ® Salicylic acid + zinc oxide

PASTA LASSAR ® is indicated as an emollient in the treatment of various skin disorders such as eczema, hemorrhoids, dry skin, dermatitis, acne and psoriasis.

Mode of action PASTA LASSAR ® Salicylic acid + zinc oxide

The therapeutic properties of PASTA LASSAR ® are to be attributed to its two active ingredients:

Zinc oxide, endowed with marked anti-irritative, cytoprotective and healing properties that, applied to the skin, is able to form a thin whitish patina useful both in recovering the histological characteristics of the damaged tissue and in protecting the region from the damaging action of ultraviolet radiation .
Salicylic acid, which for topical use is able to carry out both a significant keratolytic action, exfoliating the most superficial layers of the epidermis and thus facilitating cell renewal, is a soothing and bacteriostatic action useful above all for the cutaneous regions damaged.

However, in order for both active ingredients to carry out the aforementioned actions it is necessary that these are present in the drug at specific concentrations, thus limiting the potential side effects that would result from their more concentrated use.

Studies carried out and clinical efficacy

SALICYLIC ACID AND ACNE

J Drugs Dermatol. 2012 Dec; 11 (12): 1403-8.

Recent study that supports the use of salicylic acid in 0.5% cream in the treatment of medium-sized acne in adolescent patients, making it both effective and safe.

CYTOTOXICITY FROM ZINC

Toxicol In Vitro. 2013 Jun; 27 (4): 1187-95. doi: 10.1016 / j.tiv.2013.02.010. Epub 2013 Feb 28.

Molecular study that evaluates the molecular mechanisms of zinc oxide activity, demonstrating how this compound can cause cell death by oxidation of molecular structures, when used incorrectly.

ZINC AND GENE SETTING

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013 Feb; 31 (2): 117-20.

Interesting work that demonstrates how Zinc oxide can determine the regulation of IL8 expression in cell cultures, thus controlling the gene expression of inflammatory mediators.

Method of use and dosage

PASTA LASSAR ®

Pasta based on salicylic acid and zinc oxide

It is generally recommended to apply the appropriate amount of pasta locally, one or more times a day depending on the clinical needs.

Warnings PASTA LASSAR ® Salicylic acid + zinc oxide

The use of PASTA LASSAR ® is exclusively topical, therefore maximum caution is recommended in the application of the same avoiding ingestion or contact with mucous membranes.

It is recommended to consult your doctor immediately if the application of PASTA LASSAR ® determines the appearance of local adverse reactions, possibly also considering the need to suspend the therapy in progress.

Given the photosensitising power of the active ingredients present in PASTA LASSAR ®, it would be advisable to avoid exposure to ultraviolet rays of the treated skin region.

It is recommended to keep the medicine in a cool and dry place out of reach of children.

PREGNANCY AND BREASTFEEDING

The use of PASTA LASSAR ® during pregnancy and lactation should be justified only in cases of real necessity and should take place under strict medical supervision.

Interactions

No clinically relevant drug interactions are currently known.

Contraindications PASTA LASSAR ® Salicylic acid + zinc oxide

The use of PASTA LASSAR ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients and in patients with peripheral circulatory disorders.

Undesirable effects - Side effects

The use of PASTA LASSAR ®, especially when continued for a long time, could determine the appearance of local side effects such as redness, burning and irritation.