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prulifloxacine

Prulifloxacin is an antibacterial belonging to the class of quinolones.

More precisely, prulifloxacin is a fluoroquinolone with a bactericidal action (ie it is able to kill bacterial cells).

Prulifloxacin - Chemical Structure

Indications

For what it uses

The use of prulifloxacin is indicated for the treatment of:

  • Simple and complicated cystitis;
  • Exacerbation of chronic bronchitis;
  • Acute bacterial rhinosinusitis.

Warnings

Since prulifloxacin can cause convulsions, caution should be used when administering the drug in patients with epilepsy or other diseases that can cause seizures.

Before taking prulifloxacin, you should inform your doctor if you are in any of the following conditions:

  • If you have a history of heart rhythm disorders;
  • If there is a deficiency of the enzyme glucose-6-phosphate dehydrogenase;
  • If you suffer from liver and / or kidney disease.

If during treatment with prulifloxacin, severe diarrhea (including blood) appears, antibacterial therapy should be stopped and a doctor should be contacted immediately.

Treatment with prulifloxacin should also be stopped in the event of inflammation and tendon swelling. Also in this case it is necessary to contact the doctor immediately.

Since prulifloxacin can cause crystalluria, it is good to take plenty of fluids throughout the antibacterial treatment.

Prulifloxacin can cause photosensitization, therefore it is necessary to avoid excessive exposure to UV rays and sunlight.

Prulifloxacin can cause adverse effects that can alter the ability to drive or use machines, so care should be taken.

Interactions

Prulifloxacin should be taken two hours before or at least four hours after the administration of drugs such as cimetidine, antacids containing aluminum or magnesium and drugs containing calcium or iron, as these may interfere with the efficacy of prulifloxacin itself.

Before starting treatment with prulifloxacin, you must tell your doctor if you are taking any of the following medications:

  • Drugs used in diabetes therapy;
  • Amiodarone, quinidine or procainamide, antiarrhythmic drugs;
  • Erythromycin, clarithromycin or azithromycin, antibiotics belonging to the class of macrolides;
  • Amitriptyline, imipramine or clomipramine, antidepressant drugs;
  • Probenecid, a drug used to treat hyperuricemia;
  • Fenbufen, a non-steroidal anti-inflammatory drug (NSAID);
  • Theophylline, used in the treatment of asthma;
  • Oral anticoagulants, such as warfarin;
  • Nicardipine, a drug used in the treatment of hypertension and angina pectoris;
  • Prednisolone, a steroidal anti-inflammatory.

In any case, it is still advisable to inform your doctor if you are taking - or have recently taken - any type of medication, including over-the-counter drugs and herbal and / or homeopathic products.

Furthermore, food and milk can affect the absorption of prulifloxacin. Therefore, the drug should be taken between meals and should not be taken with milk or its derivatives.

Side effects

Prulifloxacin can cause various types of side effects, although not all patients experience them. This depends on the different sensitivity of each person towards the drug. Therefore, it is not said that all adverse effects occur with the same intensity in each patient.

The main side effects that may occur during prulifloxacin therapy are listed below.

Allergic reactions

Prulifloxacin can trigger allergic reactions in sensitive individuals. These reactions can manifest with symptoms such as:

  • Difficulty breathing;
  • Shortness of breath;
  • Swelling of eyelids, face and / or lips;
  • Rash;
  • Itch.

Skin and subcutaneous tissue disorders

Prulifloxacin therapy can cause:

  • Redness and peeling of the skin;
  • Photosensitization reactions;
  • Skin eruptions;
  • Itch;
  • Irritation of lips, tongue and mouth;
  • eczema;
  • Urticaria;
  • Stevens-Johnson syndrome;
  • Oral ulcers.

Nervous system disorders

Treatment with prulifloxacin may promote the onset of:

  • Headache;
  • dizziness;
  • Loss of appetite;
  • Numbness;
  • Loss of sensitivity to pain;
  • Alteration of the sense of taste;
  • Sleep disorders;
  • Confusion;
  • Drowsiness;
  • Restlessness.

Gastrointestinal disorders

Prulifloxacin therapy can cause abdominal pain, vomiting, diarrhea, pain or burning in the stomach, flatulence, swelling and indigestion.

Musculoskeletal disorders

Treatment with prulifloxacin may cause:

  • Tendinitis;
  • Muscle pain and / or weakness;
  • Muscle spasms;
  • Muscle damage;
  • Joint pain.

Other side effects

Other side effects that may occur during treatment with prulifloxacin are:

  • Hypoglycemia;
  • Formation of small crystals in the urine (crystalluria);
  • Malaise;
  • Temperature;
  • Hot flashes;
  • Hearing loss;
  • Irritation and redness in the eyes;
  • Increased levels of liver enzymes in the bloodstream;
  • Increased blood concentration of albumin;
  • Increased calcium blood levels;
  • Increased number of white blood cells in the bloodstream.

Overdose

If you suspect you have taken an overdose of prulifloxacin, you must contact your doctor immediately and go to the nearest hospital.

Action mechanism

Prulifloxacin performs its antibacterial action by inhibiting DNA gyrase (or bacterial topoisomerase II) and topoisomerase IV.

DNA gyrase and topoisomerase IV are bacterial enzymes involved in the supercoiling, rewinding, cutting and welding processes of the two strands that make up DNA.

With the inhibition of these two enzymes, the bacterial cell can no longer access the information contained within its genes. In this way, all cellular processes (including replication) are blocked and the beating dies.

Mode of Use - Posology

Prulifloxacin is available for oral administration as tablets.

The antibacterial agent must be taken strictly following the doctor's instructions, both as regards the amount of drug to be taken and the duration of the treatment.

The tablets should be taken with plenty of water.

Generally, the dose of prulifloxacin usually administered is 600 mg a day. Usually, the treatment lasts for ten days.

If deemed necessary, the doctor may vary the dose of the drug to be taken and the duration of the therapy.

Pregnancy and breastfeeding

The use of prulifloxacin by pregnant women and by breast-feeding mothers is not recommended.

In any case, pregnant women and breastfeeding mothers, before taking any type of medication, should always seek medical advice.

Contraindications

The use of prulifloxacin is contraindicated in the following cases:

  • In patients with known hypersensitivity to prulifloxacin itself;
  • In patients with known hypersensitivity to other fluoroquinolones;
  • In patients who have suffered from tendon problems following the use of other quinolones;
  • In patients under 18 years of age;
  • Pregnant;
  • During breastfeeding.

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