COLBIOCIN ® Chloramphenicol, Colistimethate and Tetracycline

COLBIOCIN ® is a drug based on chloramphenicol, colistimethate sodium and rolitetracycline.

THERAPEUTIC GROUP: Ophthalmology - Antimicrobials

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications COLBIOCIN ® Chloramphenicol, Colistimethate and Tetracycline

COLBIOCIN ®, given the typical antibiotic structure, is indicated in the treatment of external eye infections.

Mechanism of action COLBIOCIN ® Chloramphenicol, Colistimethate and Tetracycline

COLBIOCIN ® is a medicinal product based on antimicrobials with different antibiotic properties that significantly expand the pattern of microbial species sensitive to this treatment.

In fact, chloramphenicol is a bacteriostatic antibiotic, capable of inhibiting the proliferation of Gram positive and Gram negative bacteria, blocking the 50S ribosomal subunit and therefore interrupting all protein synthesis processes; Rolitetracilcina as well as Tetracycline are endowed with a broader spectrum of action also with regard to chlamydia, mycoplasmas, rickettsias and amoebas, also in this case supported by the ability to inhibit bacterial synthesis by blocking the 30 S ribosomal subunit; Colistin, on the other hand, particularly active against Gram-negative bacteria such as Pseudomonas and Haemophilus owes its biological efficacy to the ability to easily penetrate cell membranes, thus exerting an evident cleaning effect.

It is therefore evident the important synergy that is realized between the various active ingredients, adequately extending the effectiveness of action to different pathogenic species.

Studies carried out and clinical efficacy

THE COBIOCIN IN THE POST-OPERATIVE PHASES

Vestn Oftalmol. 1999 Nov-Dec; 115 (6): 38-40.

Work that demonstrates how the use of COLBIOCIN in the post-operative phases of keratectomy can significantly reduce hospitalization time, guaranteeing effective pain control and limiting the overlap of bacterial infections.

THE COLBIOCIN IN THE TREATMENT OF THE CHRONIC PURULENTA MESOTIMPANITE

Vestn Otorinolaringol. 1999; (2): 49-50.

Interesting Russian work that tests Colbiocin in the treatment of chronic purulent mesotympanitis, demonstrating its excellent tolerability and clinical efficacy.

COLBIOCIN IN THE JOINTS OF CLAMIDIA

Vestn Oftalmol. 1998 Mar-Apr; 114 (2): 32-4.

Study demonstrating the efficacy of Colbiocin in the treatment of chlamydial conjunctivitis in 325 patients, underlining its excellent tolerability, given the absence of serious adverse reactions.

Method of use and dosage

COLBIOCIN ®

Chloramphenicol 400 mg Eye Drops, 18 million IU Colistimethate Sodium and 500 mg Rolitetracycline;

1 g ophthalmic ointment of chloramphenicol, 18 million IU sodium colistimethate and 500 mg tetracycline.

Always according to medical indications, it is recommended to apply one or two drops of eye drops 3-4 times a day or 3-4 daily applications of ophthalmic ointment.

Warnings COLBIOCIN ® Chloramphenicol, Colistimethate and Tetracycline

The application of COLBIOCIN ® must necessarily be preceded by a careful medical examination in order to assess the prescriptive appropriateness and the possible presence of contraindications to the use of the drug.

Prolonged use of the product could increase the risk of adverse reactions and hypersensitivity to the drug, while favoring the selection of resistant antibiotic microorganisms.

For this reason treatment with COLBIOCIN ® should be limited to the time strictly necessary to guarantee remission of symptoms.

The presence of sodium sulfite among the excipients of the drug could increase the risk of allergic reactions and asthmatic attacks.

Keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of COLBIOCIN ® during pregnancy and in the subsequent period of breastfeeding is limited exclusively to cases of real need and always under the strict supervision of your doctor.

Interactions

Despite the systemic absorption of the active ingredients present in Cin OLBIOCIN ® is not very relevant, it should be remembered that the simultaneous intake of inhibitors or inducers of the cytochromial system can alter the normal pharmacokinetic characteristics of the possible share of absorbed drug.

Contraindications COLBIOCIN ® Chloramphenicol, Colistimethate and Tetracycline

The use of COLBIOCIN ® is contraindicated in patients hypersensitive to the active ingredient or to one of its excipients.

Undesirable effects - Side effects

The use of COLBIOCIN ®, especially when prolonged for a long time, could determine the appearance of local adverse reactions such as irritation, hives or angioedema such as to require the suspension of therapy.