CONDYLINE ® is a drug based on Podophyllotoxin
THERAPEUTIC GROUP: Chemotherapy for topical use
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Indications CONDYLINE ® Podophyllotoxin
CONDYLINE ® is successfully used for the topical treatment of external sharp condylomata.
Mode of action CONDYLINE ® Podophyllotoxin
CONDYLINE ® is a medicinal product based on Podophyllotoxin, an active ingredient extracted and purified from Podophyllin, a natural element present in particular plant varieties.
Its high therapeutic efficacy can be traced back to the cytolytic and keratolytic action, useful both in favoring the blockage of the cutaneous proliferation of HPV-infected cells and in the effective necrosis of the sharp condyloma.
Although the mechanism of action is not yet fully characterized, this active principle is successfully used in the treatment of external sharp condylomata, thanks also to the pharmacokinetic properties that significantly limit the risk of potential side effects.
Studies carried out and clinical efficacy
EXTRACTION AND PURIFICATION OF PODOPHILLOTOSSIN
Pharmacognosy Res. 2013 Apr; 5 (2): 93-102. doi: 10.4103 / 0974-8490.110538.
Work focused on how to obtain the Podophyllotoxin and in particular on the opportunity to extract it in vitro, thus reducing all possible sources of contamination and making the therapy as safe and effective as possible.
ANTI-INFLAMMATORY ACTIVITY OF PODO-PHYLOTOSSIN DERIVATIVES
Pharm Biol. 2013 May; 51 (5): 566-72. doi: 10.3109 / 13880209.2012.749921. Epub 2013 Jan 31.
Study that demonstrates how derivatives can be obtained starting from Podophyllotoxin with anti-inflammatory, anti-edema and analgesic activity, therefore usable in systemic pathologies such as rheumatoid arthritis.
PODOFILLOTOSSINA AND RESISTANT DRUG TUMOR CELLS
Anticancer Res. 2012 Oct; 32 (10): 4423-32.
Interesting experimental study that demonstrates the effectiveness of Podophyllotoxin in inhibiting the proliferation of human tumor cells, normally resistant to common drug therapy.
Method of use and dosage
CONDYLINE ®
5 mg cutaneous solution of Podophyllotoxin per ml of solution.
The definition of the precise therapeutic scheme is up to the doctor based on the severity of the symptoms.
Generally, it is recommended to apply the medicine twice a day, morning and evening, for three consecutive days, taking care to avoid contact of the drug with intact skin.
The aforementioned therapeutic scheme can be repeated for 5 weeks always under the supervision of your doctor.
Warnings CONDYLINE ® Podophyllotoxin
The correct use of CONDYLINE ® requires the respect of different hygienic-sanitary rules aimed at limiting the incidence of potential side effects and optimizing the therapeutic efficacy of the drug.
Thoroughly clean your hands after each application, avoid contact of the drug with your eyes and healthy skin, strictly comply with medical indications and contact your doctor following the appearance of potential side effects, they are the main guidelines to be observed during the procedure therapeutic.
It is recommended to keep the medicine out of the reach of children.
PREGNANCY AND BREASTFEEDING
The impressive antimitotic and highly irritating action of Podophyllotoxin inevitably extends the aforementioned contraindications to the use of CONDYLINE ® also to pregnancy and the subsequent breastfeeding period.
Interactions
It is recommended to avoid the use of CONDYLINE ® together with that of other Podophyllotoxin drugs.
Contraindications CONDYLINE ® Podophyllotoxin
The use of CONDYLINE ® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients, during pregnancy and lactation and in small pediatric patients.
Undesirable effects - Side effects
The use of CONDYLINE ® is not free from undesirable effects, which occur especially during the second or third day of treatment, when condyloma necrosis begins to occur.
Local irritation, tenderness, erythema and small ulcerations are the main local adverse reactions described, while fortunately the systemic ones are rarer.
Note
CONDYLINE ® is a prescription drug prescribed.
