MICONAL ® - Miconazole

MICONAL ® is a drug based on Miconazole nitrate

THERAPEUTIC GROUP: Antimycotics for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications MICONAL ® - Miconazole

MICONAL ® is indicated in the treatment of dermatomycoses sustained by dermatophytes, yeasts and fungi sensitive to miconazole and in the treatment of vaginal or vulvo-vaginal fungal infections.

Mechanism of action MICONAL ® - Miconazole

MICONAL ® is a medicinal product based on Miconazole, an active ingredient belonging to the family of imidazole derivatives and therefore has a marked fungistatic, fungicidal and bactericidal activity against Gram positive organisms.

The aforementioned therapeutic activities are due to the biological role of Miconazole, effective in inhibiting a series of enzymes involved in the biosynthesis of Ergosterol, a key element of the fungal plasma membrane important in preserving its functional and structural characteristics.

The impairment of the physiological membrane activity, three of which is that of the barrier, and the accumulation of catabolites endowed with marked oxidizing activities reduce the vital capacity of the micro-organism, causing its death in a short time.

The low systemic absorption, which derives from the topical use of this drug, makes the use of MICONAL ® even easier and safer.

Studies carried out and clinical efficacy

PROPOLIS AND MICONAZOLE IN STOMATITIS TREATMENT

Evid Based Complement Alternat Med. 2013; 2013: 947980. doi: 10.1155 / 2013/947980. Epub 2013 May 2.

Interesting work that shows how Brazilian green propolis can have therapeutic effects similar to those of Miconazole in the treatment of oral cavity stomatitis supported by Candida, thus earning the title of natural antifungal.

THE MICONAZOLE IN THE TREATMENT OF CANDIDA COMPLICATED DERMATITIS

Pediatr Dermatol. 2013 May 16. doi: 10.1111 / pde.12107. [Epub ahead of print]

Clinical trial demonstrating the efficacy of adding modest amounts of Miconazole to the treatment of dermatitis complicated by cutaneous candidiasis, thus revealing an effective and perfectly tolerated treatment.

MICONAZOLO IN MUCOADESIVE TABLETS

Clin Infect Dis. 2012 May; 54 (10): 1480-4. doi: 10.1093 / cid / cis205. Epub 2012 Apr 10.

Innovative pharmacokinetic study that demonstrates the efficacy and excellent tolerability of new Miconazole delivery systems, such as adhesive mucus tablets, which have proved useful in the treatment of oropharyngeal candidiasis.

Method of use and dosage

MICONAL ®

Cream for cutaneous use of 20 mg of Miconazole nitrate per gr of product;

Dermatological powder 20 mg of Miconazole nitrate per gr of product;

Gynecological cream with 2% Miconazole nitrate;

Vaginal ovules of 30 mg of Miconazole nitrate;

1200 mg vaginal capsules of Miconazole nitrate;

0.2% vaginal lavage of Miconazole base.

The choice of the pharmaceutical format, the dosing schedule and the timing of administration is the responsibility of the competent doctor, taking into account the physio-pathological characteristics of the patient, the severity of his clinical picture and the therapeutic goals to be achieved.

Depending on the format chosen, the application methods and related precautions will inevitably change.

Generally, 1-2 applications per day are recommended for MICONAL ® in dermatological cream and powder, 2 vaginal ovules per day for MICONAL ® in vaginal ovules, 2 applications per day of MICONAL ® vaginal cream and a single capsule for two consecutive days for MICONAL ® vaginal capsules.

Warnings MICONAL ® - Miconazole

Although therapy with MICONAL ® is generally safe, it should be preceded by a thorough medical examination to clarify the infectious origin of the lesion and its symptomatology and the consequent prescription appropriateness.

It would also be advisable for the patient to comply with all the sanitary regulations of the case, in order to reduce the potential side effects of the therapy, while maximizing its therapeutic efficacy.

As with any other topical drug, it should be remembered that prolonged use of MICONAL ® could cause the onset of sensitization reactions, such as to require the suspension of the therapy in progress.

It is advisable to keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The absence of clinical trials able to fully characterize the safety profile of Miconazole for fetal health generally extend the contraindications to the use of MICONAL ® also to pregnancy and the subsequent period of breastfeeding.

If the use of this drug is strictly effective, medical supervision would be necessary.

Interactions

Drug interactions worthy of clinical note are currently unknown.

Contraindications MICONAL ® - Miconazole

The use of MICONAL ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients.

Undesirable effects - Side effects

The use of MICONAL ®, especially if prolonged for a long time, could determine the appearance of local side effects such as redness, burning and irritation, which fortunately regress readily once therapy is suspended.