Melatonin 500 - Eurosup

Information about Melatonin 500 - Eurosup

Food supplement based on Melatonin

FORMAT

Pack of 60 tablets

COMPOSITION: Stabilizer: microcrystalline cellulose; Anti-caking agent: magnesium stearate and silicon dioxide; Melatonin.

FOR CAPSULE: Melatonin 5 mg

Product Features of Melatonin 500 - Eurosup

Melatonin : it is naturally synthesized in the body, in a gland placed at a diencephalic level and defined as an epiphysis or pineal gland.

The epiphysis plays a mediating role between the external environment and the endocrine activity, regulating its activity based on the photoperiod. In fact, the presence of photocopiers seems to significantly modulate the production of melatonin, inhibiting it in the presence of light and promoting it in the absence of light stimuli. All this translates into a rhythmic production of melatonin, which is maximum during the night and then significantly decreases during the day. It is therefore possible to consider this substance as the biological clock of the human organism, because by activating different types of receptors, disseminated at the encephalic level (above all hypothalamic), it can act as a sedative and hypnotic inducing sleep. The production of melatonin is maximum during the first 7 years of life, and then gradually decreases (in reality the synthesis levels remain constant, while the blood volume increases), and become minimal in the elderly, where the reduced innervation on one side and epiphyseal calcification on the other, seriously compromise the endocrine function of this gland. The oral integration of melatonin, fortunately, has been shown to temporarily reduce the endogenous secretion of this hormone, delaying the exhaustion and aging of the pineal gland and preserving its functionality.

Although there are many studies in the literature, it is still not possible to draw a complete profile of all the potential functionalities of this molecule; therefore we will describe the main biological aspects in which it is involved:

Sleep / wake rhythm: by interacting with receptors disseminated at the hypothalamic level, melatonin can exert a hypnotic and sedative effect;
Biological protection: exercised not only on the pineal gland, but generalized to the whole organism (given the protective action described with respect to nucleic acids subjected to chemical stress);
Antioxidant processes: melatonin is directly involved in the detoxification system by oxygen and nitrogen free radicals, contributing - together with its metabolites - to total antioxidant capacities;
Immune system: it is able to strengthen the body's immune defenses, antagonizing the immuno-depressive effects induced by acute stress and improving both the pro-inflammatory cytokine secretion and the differentiation and activation of the lymphocyte cell component;
Metabolic pathways: recent evidence is demonstrating an important role of melatonin, and its MT1 receptor, in carbohydrate metabolism. Indeed, receptor activation appears to improve insulin sensitivity, reducing the risk of type II diabetes and associated diseases such as obesity.

Melatonin in sports

Although it is difficult to justify and describe the advantages deriving from the use of melatonin in sports, the scientific literature provides some interesting points of reflection on possible applications of this supplement:

Improvement of hormonal function: the role of a biological clock for melatonin could be particularly important to improve hormone secretion in individuals subjected to intense training. Although the literature is not very rich in such studies, there are some scientific evidences that correlate the increase in nocturnal GH secretion with the administration of melatonin.
Protective action: the antioxidant action of melatonin could be important in counteracting the oxidative damage induced by intense physical exercise.
Metabolic action: despite the lack of scientific evidence on men, in animal studies melatonin induced a reduction in lactate synthesis, probably associated with the previously described metabolic effect on glucose tolerance.
Thermoregulatory action: some evidence suggests that the drop in body temperature, recorded following the intake of melatonin, may be beneficial for athletes subjected to training and performance at high temperatures.

Rationale - Melatonin 500 - Eurosup

Although the ideas for application in the sports field are interesting, it is important to remember that the main therapeutic indication of melatonin is related to the treatment of various sleep disorders; however, there is no lack of studies that prove its efficacy in neurodegenerative, endocrine and metabolic diseases. In sport, however, there is no improvement in melatonin-dependent performance or body composition, although there is evidence of its hormone-regulating and antioxidant utility.

Recommended use by company - Melatonin 500 - Eurosup

Swallow one serving (1 tablet) preferably in the evening, an hour before bedtime.

Use in sports practice Melatonin 500 - Eurosup

In most of the studies dosages ranging from 300 mcg to 5/6 mg are administered. In sports, the recommended dosage is 3 milligrams, although studies exist to support the efficacy of only 0.5 mg. In any case, melatonin should be taken at least an hour before bedtime, so as to be available during the falling asleep phase. The nocturnal assumption is also important to reproduce the cicardianicità of its synthesis, avoiding a hormonal deregulation that could even be counterproductive.

Synergy - Melatonin 500 - Eurosup

Several studies seem to agree on the greater efficacy of synergy when taken together with zinc. A generalized improvement is obtained both on the strengthening of the immune defenses, on the antioxidant effect and on the metabolic aspect, improving insulin sensitivity.

Some studies show that in the case of prolonged intake of zinc and melatonin, integration with magnesium magnesium also becomes necessary.

The validity of the simultaneous administration of melatonin and vitamin B6, is still under observation, even if the first works show an improvement in the endogenous synthesis of this hormone, with an enhancement of the biological effects related above all to the modulation of the immune and hormonal activity .

Side effects Melatonin 500 - Eurosup

Although recent studies have confirmed the high tolerability and safety of the active ingredient, there are cases in literature in which, even at a dose of 3 mg / day, nausea, irritability, nightmares and vascular changes have been observed.

Furthermore, acting as a mild hypnotic and sedative, melatonin may interfere with concentration. By enhancing the immune response, the substance could also worsen the condition of patients suffering from allergic or autoimmune diseases.

Precautions for use Melatonin 500 - Eurosup

The product is contraindicated in cases of renal or hepatic disease, cardiovascular disease and / or hypertension, allergies and autoimmune diseases, during pregnancy, during breastfeeding, under 12 years and for adolescents not yet trained.

In the event of prolonged use (over 6/8 weeks), medical advice is required.

This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Further information on the critical analysis of Melatonin 500 - Eurosup.

BIBLIOGRAPHY

Neuro Endocrinol Lett. 2002 Jun; 23 (3): 213-7.

The effect of pyridoxine administration on melatonin secretion in normal men.

Luboshitzky R, Ophir U, Ship R, Epstein R, Shen-Orr Z, Herer P.

Georgian Med News. 2007 Dec; (153): 35-8.

[Pyridoxine (vitamin B6) influence on endogenic melatonin production during the experiment]

rsling M, Wheeling M, Williams A. The effect of melatonin administration on pituitary hormone secretion in man. Clin Endocrinol. 1999; 51: 637-42. doi: 10.1046 / j.1365-2265.1999

Melatonin supplementation to rats subjected to acute swimming exercise: effect on plasma levels and relation with zinc.

Kaya O, Gokdemir K, Kilic M, Baltaci AK.

Neuro Endocrinol Lett. 2006 Feb-Apr; 27 (1-2): 263-6.

Effects of a single dose of N-Acetyl-5-methoxytryptamine (Melatonin) and resistance exercise on the growth hormone / IGF-1 axis in young males and females.

Nassar E, Mulligan C, Taylor L, Kerksick C, Galbreath M, Greenwood M, Kreider R, Willoughby DS.

Effects of melatonin supplementation on exercise-induced changes in conduction velocity distributions.

Ayaz M, Okudan N.

Improvement of the conductive capacities of the nerve fibers.

Melatonin: aeromedical, toxicopharmacological, and analytical aspects.

Sanders DC, Chaturvedi AK, Hordinsky JR.

J Anal Toxicol. 1999 May-Jun; 23 (3): 159-67. Review.

BMJ. 2006 Feb 18; 332 (7538): 385-93. Epub 2006 Feb 10.

Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.

Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, Vohra S, Klassen TP, Baker G.

Safe in the short term

Pharmacokinetics of orally administered melatonin in critically ill patients.

Mistraletti G, Sabbatini G, Taverna M, Figini MA, Umbrello M, Magni P, Ruscica M, Dozio E, Exposed R, DeMartini G, Fraschini F, Rezzani R, Reiter RJ, Iapichino G.

J Pineal Res. 2010 Mar; 48 (2): 142-7. Epub 2010 Jan 8.

Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity.

Tan DX, Manchester LC, Fuentes-Broto L, Paredes SD, Reiter RJ.

Obes Rev. 2010 Jun 16. [Epub ahead of print]

Obesity (Silver Spring). 2010 Feb 18. [Epub ahead of print]

Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse.

Contreras-Alcantara S, Baba K, Tosini G.

Endocrinology. 2009 Dec; 150 (12): 5311-7. Epub 2009 Oct 9.

Melatonin improves glucose homeostasis and endothelial vascular function in high-fat diet-fed insulin-resistant mice.

Sartori C, Dessen P, Mathieu C, Monney A, Bloch J, Nicod P, Scherrer U, Duplain H.

Int J Exp Pathol. 2007 Feb; 88 (1): 19-29.

Intake of melatonin is associated with amelioration of physiological changes, both metabolic and morphological pathologies associated with obesity: an animal model.

Hussein MR, Ahmed OG, Hassan AF, Ahmed MA.

Endocrinology. 2003 Dec; 144 (12): 5347-52. Epub 2003 Sep 11.

Melatonin reduces body weight gain in Sprague Dawley rats with diet-induced obesity.

Prunet-Marcassus B, Desbazeille M, Bros A, Louche K, Delagrange P, Renard P, Casteilla L, Pénicaud L.

Saudi Med J. 2006 Oct; 27 (10): 1483-8.

Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin.

Hussain SA, Khadim HM, Khalaf BH, Ismail SH, Hussein KI, Sahib AS.

Eur J Appl Physiol. 2006 Apr; 96 (6): 729-39. Epub 2006 Feb 28.

Effects of resistance exercise session after oral ingestion of melatonin on physiological and performance responses of adult men.

Mero AA, Vähälummukka M, Hulmi JJ, Kallio P, von Wright A.

J Pineal Res. 2005 Nov; 39 (4): 353-9.

Effects of melatonin on the thermoregulatory responses to intermittent exercise.