TRAVOCORT ® - Diflucortolone valerate and Isoconazole nitrate

TRAVOCORT ® is a drug based on Diflucortolone valerate and Isoconazole nitrate

THERAPEUTIC GROUP: Antimycotics for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications TRAVOCORT ® - Diflucortolone valerate and Isoconazole nitrate

TRAVOCORT ® is indicated for the treatment of dermatomycoses sustained by dermatophytes, fungi and yeasts sensitive to Icomazole even when characterized by a strong inflammatory or eczematous component.

Mechanism of action TRAVOCORT ® - Diflucortolone valerate and Isoconazole nitrate

TRAVOCORT ® owes its therapeutic efficacy to its two active ingredients with different but complementary biological activities:

Isoconazole is a broad-spectrum imidazole derivative endowed with fungicidal and fungistatic activity performed through the inhibition of the 14 alpha methyl lanosterol demethylase enzyme involved in the biosynthesis of Ergosterol, an important sterol in maintaining the structural and functional characteristics of the plasma membrane, whose absence compromises the vitality of the microorganism;
Diflucortolone valerate, on the other hand, is a topical corticosteroid with anti-inflammatory, antipruritic and vasoconstrictor activity mediated by the action against histamine, the ability to inhibit the production of inflammatory cytokines and the ability to stabilize lysosomal membranes

The topical use of the aforementioned active ingredients, characterized by low systemic absorption, significantly limits the incidence of side effects normally associated with systemic therapy.

Studies carried out and clinical efficacy

CLINICAL EFFECTIVENESS OF THE DIFLUCORTONE ASSOCIATION - ISOCONAZOLE

Mycoses. 2013 May; 56 Suppl 1: 38-40. doi: 10.1111 / myc.12046.

Clinical case that reports the efficacy of the Diflucortolone - Isoconazole association in the treatment of erythrasma, a clinical condition characterized by burns, itching and rash-like skin lesions in a young patient of 13 years.

TRAVOCRT AND TINEA CORPORIS

Mycoses. 2013 May; 56 Suppl 1: 30-2. doi: 10.1111 / myc.12068.

Recent work that demonstrates the clinical efficacy of TRAVOCORT, highlighting the ability of this drug to guarantee a remission of the symptoms present during body ringworm complicated by over-bacterial infections in just one week of treatment.

TRAVOCORT CLINICAL EFFECTIVENESS

Mycoses. 2013 May; 56 Suppl 1: 23-5. doi: 10.1111 / myc.12056.

Further study describing the clinical efficacy of TRAVOCORT, describing the ability of this drug to guarantee a prompt remission of the symptomatology present in the course of ringworm of the foot complicated by over-bacterial infections in a diabetic patient

Method of use and dosage

TRAVOCORT ®

Cream for cutaneous use of 0.1 g of Diflucortolone valerato and 1 g of Isoconazole nitrate per 100 g of product.

Generally, always under the indication of your doctor, the use of two daily applications, of the correct quantity of cream on the region affected by the infection is sufficient to guarantee a remission of the symptoms.

Given the presence of corticosteroids it would be appropriate to limit the use of TRAVOCORT ® to one week.

Warnings TRAVOCORT ® - Diflucortolone valerate and Isoconazole nitrate

The use of TRAVOCORT ® should be preceded by a careful medical examination in order to clarify the origin of the complained lesion and any prescriptive appropriateness.

The patient taking this medicine should:

clean hands thoroughly after application to avoid spreading the drug into the environment;
avoid exposure of the treated region to ultraviolet radiation;
avoid contact of the drug with frankly damaged skin, with eyes and with mucous membranes;
consult your doctor if you experience any side effects.

It is advisable to keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of TRAVOCORT ® during pregnancy and in the subsequent period of breastfeeding should take place under the strict supervision of your doctor and in case of real need.

Interactions

Drug interactions worthy of clinical note are currently unknown.

Contraindications TRAVOCORT ® - Diflucortolone valerate and Isoconazole nitrate

The use of TRAVOCORT ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients and in the presence of tuberculosis, lactic and viral lesions.

Undesirable effects - Side effects

The use of TRAVOCORT ® is generally safe and well tolerated, although the application continues over time or over large regions could cause the onset of hypopigmentation, irritation, burning sensation, hypertrichosis and other side effects related to the presence of diflucortolone.