DECA-DURABOLIN ® is a drug based on Nandrolone decaonato
THERAPEUTIC GROUP: Androgens
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Indications DECA-DURABOLIN ® - Nandrolone
DECA-DURABOLIN ® is used in the treatment of symptoms in male subjects with androgen deficiency, or as adjuvant therapy in some forms of osteoporosis.
Action mechanism DECA-DURABOLIN ® - Nandrolone
Nortestosterone, more commonly known as Nandrolone, is a derivative of testosterone, from which it differs in the presence of a methyl group in position 19, which gives it a long duration of action (estimated around 130 hours) and above all a reduced androgenizing power, responsible for numerous side effects of androgen-based hormone replacement therapy such as acne, hirsutism, alopecia and prostatic hypertrophy.
However, this metabolite, normally present in the metabolic pathways of steroid hormones, maintains a modest estrogenic effect, linked to the conversion by aromatase, and a similar progestinic activity, capable of inhibiting feedback to the hypothalamic-pituitary axis reducing gondatropin secretion, therefore also the endogenous testosterone.
At the same time the nandrolone contained in DECA-DURABOLIN ® maintains the same anabolic power as testosterone:
- Improving hematopoiesis and ensuring a significant increase in serum hemoglobin and the number of erythrocytes;
- Positivising the nitrogen balance, with an increase in protein synthesis levels, responsible for the inductive effect on muscle masses;
- Modulating bone turnover in favor of neodeposition processes, increasing intestinal calcium absorption and increasing bioavailability, thus protecting the patient from the risk of osteoporosis;
- Improving sexual function, also significantly affecting sexual libido;
- Contributing to the development, maturation and maintenance of male secondary sexual characteristics.
Studies carried out and clinical efficacy
1. NANDROLONE IN PATIENTS WITH HIV
Clinical trial that demonstrates how the administration of nandrolone can benefit the health status of the HIV-infected patient, counteracting cachexia and improving body weight, lean mass and quality of life of these patients.
2. NANDROLONE AND NON-HYPERTROPHY: Experimental study
Experimental study, which dispels some of the promises for which nandrolone would be used in sports. More precisely, the administration of this hormone in mice did not lead to hypertrophy of the soleus muscle, even when combined with physical exercise of resistance
3. NANDROLONE IN REFRACTORY ANEMIA AT THE EPO
Work showing a new therapeutic approach to erythropoietin-refractory anemia. In these rare cases the administration of nandrolone seems not only to improve the number of erythrocytes but also that of white blood cells and platelets.
Method of use and dosage
DECA-DURABOLIN ®
Injectable oily solution intramuscularly contained in vials of 25 or 50 mg of nandrolone decanoate:
in light of the chemical-structural and pharmacokinetic characteristics of nandrolone, this hormone should be taken on average every 3 weeks.
The dosage to be used, usually between 25 and 50 mg per injection, should instead be defined by your doctor, after a careful evaluation of the patient's clinical conditions.
Warnings DECA-DURABOLIN ® - Nandrolone
The intake of DECA-DURABOLIN ® must necessarily be preceded by a careful medical examination useful to assess the prescriptive appropriateness and the possible presence of morbid conditions, whose clinical course could worsen following the use of nandrolone.
In this regard, patients suffering from hypertension, heart disease, family history or history of neoplastic diseases, liver and kidney diseases and epilepsy should carefully evaluate with their doctor the cost / benefit ratio that would result from the use of nandrolone, considering the need to resort to to periodic checks useful for monitoring the patient's psycho-physical state of health.
Especially in the initial phase of administration, the intake of DECA-DURABOLIN ® should be supervised by health personnel, given the possible complications related to intramuscular injections poorly made with oily material.
At the onset of the first clinical biological disorders or at the first signs of sexual or nervous hyperstimulation, the doctor should stop the treatment.
The use in prepubera age should instead take place with particular attention, given the possible deleterious effects on bone growth and on the too rapid development of the male genital organs.
By decree of the Ministry of Health 11 June 2010, published in the Official Journal n. 145 of 24 June 2010, the substance
NANDROLONE (common name)
17-HYDROSSI-4-ESTREN-3-ONE (chemical name)
19-NORTESTOSTERONE (other name)
has been inserted, with affection since July 9, 2010, in Table I and Table II, section A of narcotic and psychotropic substances. Among the reasons we read that this substance was included among the drugs at the request of the "Commission for the supervision and control of doping and for the protection of health in sports" and on the positive opinion of the competent advisory bodies of the Ministry of Health. For this substance, in fact, concrete dangers have been found to induce serious psychic dependence.
PREGNANCY AND BREASTFEEDING
Nandrolone is able to cross the hematoplacental barrier, thus reaching the fetal circulation and thus inducing virilization of the fetus, potentially responsible for reproductive problems.
In light of these data the use of DECA-DURABOLIN ® is contraindicated both during pregnancy and in the subsequent period of breastfeeding.
Interactions
Although at the moment there are still few studies able to characterize the possible drug interactions of nandrolone, it is useful to remember, as it is a direct derivative of testosterone, its intake if carried out in conjunction with anticoagulants, hypoglycemic agents or corticosteroids could increase the risk respectively. of bleeding, hypoglycemia and hypertension.
Contraindications DECA-DURABOLIN ® - Nandrolone
The use of nandrolone is contraindicated in case of hypersensitivity to the active substance or to one of its excipients, breast cancer, estrogen-dependent neoplasms, prostatic cancer and hypertrophy, history of hepatocarcinoma, hypercalcaemia, nephrotic syndrome, pregnancy and lactation.
Undesirable effects - Side effects
Although nandrolone can significantly reduce the appearance of side effects typical of androgen therapy such as acne, water retention, hypertension, myalgia, taking DECA-DURABOLIN ® especially when performed outside of medical indications, could be responsible for side effects as inhibition of spermatogenesis in humans, reduced glucose tolerance and increased triglyceride blood concentrations.
The use of DECA-DURABOLIN ® for anabolic purposes in women, could be associated with virilization resulting in hirsutism, increased libido, acne, and hoarseness.
Note
DECA-DURABOLIN ® is salable only under medical prescription.
DECA-DURABOLIN ® is an anabolic agent, therefore its use, outside of medical prescriptions on pathological grounds, is prohibited in the race and out of the race.
By decree of the Ministry of Health 11 June 2010, published in the Official Journal n. 145 of 24 June 2010, the substance
NANDROLONE (common name)
17-HYDROSSI-4-ESTREN-3-ONE (chemical name)
19-NORTESTOSTERONE (other name)
has been inserted, with affection since July 9, 2010, in Table I and Table II, section A of narcotic and psychotropic substances. Among the reasons we read that this substance was included among the drugs at the request of the "Commission for the supervision and control of doping and for the protection of health in sports" and on the positive opinion of the competent advisory bodies of the Ministry of Health. For this substance, in fact, concrete dangers have been found to induce serious psychic dependence.
