HMB 3000MG - M. Double You

About HMB 3000MG - M. Double You

HMB 3000MG - M.DOUBLE YOU

Food supplement based on hydroxy beta methyl butyrate

FORMAT

120 cps bottle

COMPOSITION

Hydroxy beta methylbutyrate (HMB)

Capsule: edible gelatin

Chelating agent: potassium phosphate

One capsule contains: hydroxy beta methyl butyrate 750 mg

Product Features HMB 3000MG - M. Double You

Hydroxy beta methyl butyrate - little present in food, HMB is synthesized in our body starting from the essential amino acid leucine, for an average quantity of about 200 / 400mg a day. Not yet completely clear is the pharmacokinetic and pharmacodynamic profile of this compound, although for about 15 years it has been experimenting in various sectors, including sports. Given the low quantity produced endogenously, and given the studies reporting ergogenic effects at about 3 gr / day, the best source of intake remains the oral supplement, for which there is a high bioavailability. In fact, at 1 gram of HMB, only 14% of the product is eliminated with urine, while this quantity rises to 29% if taken at a dose of 3 grams. Generally the blood peak is reached 2 hours after its ingestion, with a return to baseline after 9 hours. However, the biodistribution of the molecule remains unclear, which represents a limitation in the development of optimal supplementary protocols. The biological effect, on the other hand, translates into the regulation of protein turnover, with an increase in protein synthesis and reduction of degradation processes, with a decline in apoptotic phenomena and with a potential protection from oxidative damage.

For these reasons the HMB has been successfully used in counteracting cachexia in patients suffering from AIDS or from oncological pathologies, for which in addition to the lack of reduction, an increase in muscle mass has been recorded. HMB has also been shown to be effective in reducing wasting in elderly individuals and in preventing the cytotoxic effects of lipopolysaccharide. Further experiments are also ascertaining the possibility of improving the lipidemic profile, decreasing the circulating levels of LDL (possible application in cardiovascular diseases) and counteracting tumor proliferation.

HMB in sports practice HMB 3000MG - M. Double You

Given the effects of body composition distribution observed in cachectic patients, a potential use in sports was thought with the intent of:

• Increase muscle mass (increase in protein synthesis and reduction of degradation);
• Improve athletic performance (strength and endurance);
• Protect the muscle from damage induced by intense exercise;
• Counteract the feeling of fatigue.

Rational of use in HMB 3000MG sports practice - M. Double You

Numerous studies have tested the potential of this supplement, using 3 grams per day as a standard dosage and recording mixed results. Despite this - although it is still difficult to draw definitive conclusions and to investigate the biological and pharmacodynamic role of this molecule - from the various studies there are some results on some aspects:

1. Increased strength in untrained subjects subjected to integration (the question remains on the variability of response to training, given that we start from untrained subjects);
2. Reduction of markers of muscle damage (Creatine kinase and lactic dehydrogenase).
3. Ineffectiveness of acute supplementation: there is no positive effect, following administration of HMB limited to one week or less;
4. No effect on the increase in lean mass in trained athletes.

Possible ergogenic effects on trained athletes or individuals are still very uncertain. It should be noted that unlike other supplements, in this case there are experimental studies, some of which have beneficial effects.

Suggested use by the company - HMB 3000MG - M. Double You

1/2 capsules a day when swallowed with plenty of water.

Mode of use in HMB 3000MG sports practice - M. Double You

The recommended dosage, and most used, is that of 3 grams per day divided throughout the day.

Pharmacokinetic studies of the compound define the optimal dose at 38 mg / kg, defining doses of less than 1 gram as those with reduced clearance.

Supplementation should be prolonged for at least 3/4 weeks, and many define it as indicated in the start-up phase for sporting activity .

Given the dose of 750 mg per capsule, a supplementary protocol could include taking a tablet in the morning, a pre-workout, a post-work-out and finally a bedtime.

There is no evidence concerning the biodistribution of HMB, so it is also difficult to recommend taking it preferably on a full or empty stomach. The presence of glucose, however, appears to delay the blood peak by about 1 h without affecting other pharmacokinetic parameters.

How to optimize your business HMB 3000MG - M. Double You

The synergy with glutamine and arginine has proven to be useful in preventing the decrease in lean mass in patients suffering from AIDS and oncological diseases, while that with arginine and lysine has been able to guarantee an increase in both strength and lean mass in elderly subjects subjected to training .

It would make sense, even if unproven, to administer BCAA at the same time, which could help reduce proteolysis and increase protein synthesis.

Even the simultaneous administration of antioxidants could prevent the accumulation of oxidation products induced by ROS, and delay the sensation of fatigue contributing to the improvement of performance.

Concomitant creatine supplementation has proved ineffective in several studies to support the ergogenic effects of HMB.

Side Effects HMB 3000MG - M. Double You

The administration of HMB appears to be well tolerated at doses between 3 and 6 grams per day, and well documented in the literature even for several weeks of administration.

Animal studies also show how very high doses are tolerated.

A reduction in blood pressure was recorded in some studies following the administration of HMB, but this appears to be due to the presence of calcium in the product.

Precautions for use HMB 3000MG - M. Double You

The product is contraindicated in cases of renal or hepatic disease, cardiovascular disease and / or hypertension, during pregnancy, during lactation, under 12 years and for adolescents not yet trained.

In the event of prolonged use (over 6/8 weeks), medical advice is required.

This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Further information on the critical analysis of HMB 3000MG - M. Double You.