HMB - EAS

About HMB - EAS

HMB - EAS

Food supplement based on hydroxy beta methyl butyrate

FORMAT

200 cps bottle

COMPOSITION

Hydroxy beta methylbutyrate (HMB): salified with calcium

Capsule: edible gelatin

Anti-caking agents: Magnesium stearate, silicon dioxide, Potassium phosphate e

Calcium phosphate

One capsule contains: Hydroxy beta methyl butyrate 250 mg

Product features HMB - EAS

Hydroxybetyl methyl butyrate - scarcely present in nature (fish is the best source), it is a derivative of the alpha-keto isocaproate, ketoacid originated after transamination of the branched-chain amino acid leucine. The supplement therefore represents the best source of employment. Preliminary pharmacokinetic studies have shown that at the oral 1gr dose, a plasma peak occurs after 2h, with renal elimination of about 14% of the original dose. At the dose of 3 g, on the other hand, the blood peak is anticipated per hour, while the clearance reaches 29%. Concomitant glucose administration delays the peak by about one hour, but its clearance remains unchanged. The subsequent distribution of this molecule among the various tissues is still unclear, and the possible efficacy of insulin-mediated intake, as instead occurs for branched-chain amino acids.

The biological functioning mechanism of HMB is still unclear, but it is certainly involved in the modulation of protein homeostasis.

It is assumed to play a direct role in improving protein synthesis, and in inhibiting protein degradation via ubiquitin proteasome. Moreover, from studies carried out on animal models, it appears to have an antioxidant and antiapoptotic potential which still needs to be characterized.

The interest of the HMB from the commercial point of view is due to the effects recorded on cachectic individuals, on elderly individuals and on animal models, in which the administration of HMB has definitely improved the protein turnover, significantly increasing the lean mass and exhibiting a potential beneficial effect on the lipidemic and immune profile.

Naturally the application in the sports field finds meaning, given the modulating role in protein synthesis.

Rational integration into HMB - EAS sports practice

From a recent review, which examined all the studies in the literature concerning the use of HMB in sports, it emerged that about 394 individuals were enrolled (still few to draw statistically significant conclusions) and that the results seem be somewhat discordant. However, it seems that the best ergogenic effects are registered on untrained individuals, with an increase in maximum strength, and a reduction in markers of muscle damage induced by physical activity, while the integration in trained individuals seems to be ineffective. The variation of the body composition, induced by HMB, identifiable exclusively on untrained individuals, for which it must also take into account the individual variability of the response to physical exercise, is also of little significance.

Recommended use by the company - HMB - EAS

It is recommended to take 4 capsules 3 times a day.

Use in HMB - EAS sports practice

In studies in which there are encouraging results, the established dosage is 3 grams per day, while from pharmacokinetic tests the optimal dosage appears to be 38 mg / kg.

Acute administration is completely ineffective, and the various studies seem to agree on this. In order to minimize the renal elimination of the product, it would be appropriate to divide the daily dosage into 3 doses of 1 g, while there is still no evidence on the effectiveness of HMB absorption on an empty or full stomach.

The product in question has capsules with 250 mg of HMB each, inevitably with the pros and cons:

1. PRO: possibility to modulate the dosage considerably;
2. CONS: many capsules (4) to be swallowed to reach the dosage of 3 gr.

The suggested delivery schedule includes 1 g at breakfast, one post-workout and one before bedtime, for at least 4 weeks. However, the mechanism of action has not yet been clarified, the potential benefits that could derive from a pre-workout administration are not known, taking into account that the plasma peak is obtained after 2h, for the dose of 1 gr.

How to optimize your HMB - EAS business

Synergy with creatine seems completely ineffective and documented by several studies.

More rational, and theoretically justified but experimentally not yet proven, could be the simultaneous administration of BCAA, enhancing the anticatabolic effect of HMB.

On the contrary, the beneficial effect of preserving and increasing the lean mass, obtained following the administration of HMB with arginine and glutamine in cancer and AIDS patients, and of HMB with arginine and lysine in elderly men and women has been demonstrated.

HMB - EAS side effects

The administration of HMB appears to be well tolerated at doses between 3 and 6 grams per day, and well documented in the literature even for several weeks of administration.

Animal studies also show how very high doses are tolerated.

A reduction in blood pressure was recorded in some studies following the administration of HMB, but this appears to be due to the presence of calcium in the product.

Precautions for use HMB - EAS

The product is contraindicated in cases of renal or hepatic disease, cardiovascular disease and / or hypertension, during pregnancy, during lactation, under 12 years and for adolescents not yet trained.

In the event of prolonged use (over 6/8 weeks), medical advice is required.

This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . More information on the critical analysis of HMB - EAS.