BIODERMATIN ® - Biotin

BIODERMATIN ® is a drug based on Biotin

THERAPEUTIC GROUP: Biotin

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications BIODERMATIN ® - Biotin

BIODERMATIN ® is indicated in the treatment of biotin deficiency states and as a therapeutic adjuvant for the treatment of seborrheic and desquamative skin diseases.

Mechanism of action BIODERMATIN ® - Biotin

Biotin is a water-soluble vitamin of group B, therefore defined as vitamin B8, biologically indispensable given its role as a cofactor for enzymes known as carboxylases, involved in the synthesis of fatty acids and glucose through the process of gluconeogenesis, and in the catabolism of some essential amino acids such as leucine, cholesterol and fatty acids.

Its molecular activities are translated macroscopically into a series of reactions useful for cellular survival, and in particular of those tissues with a high turnover as the epidermis and its annexes.

In fact the deficiency of this vitamin, observable in patients subjected for long periods of time to parenteral nutrition or unhealthy eating habits, such as the consumption of raw eggs, is manifested by a series of symptoms characterized by hair loss, desquamative skin rashes, symptoms neurological disorders such as depression, lethargy and hallucinations and in more serious cases with recurrent bacterial and fungal infections due to a widespread state of immunodepression.

Studies carried out and clinical efficacy

1. BIOTINE AND SKIN ANNEXES

Study conducted on a family with a genetic syndrome characterized by the particular fragility of skin appendages, in which the intake of biotin has proved useful in improving symptoms, guaranteeing a gradual remission.

2. LACK OF BIOTIN IN ALLERGIC INFANTS

Case report demonstrating the serious risk for infants with milk protein allergy, incurring a biotin deficiency associated with the use of biotin-free amino acid supplements.

3. BIOTINE WITH HIGH DOSAGE AND LOSS OF TASTE

Very interesting study that focuses on a potential side effect of biotin taken at high doses such as loss of taste. This symptom seems to weigh heavily on the patient's quality of life.

Method of use and dosage

BIODERMATIN ®

Biotin 5 mg oral tablets;

effervescent granules of 5 or 20 mg of biotin;

5 mg solution for injection of biotin.

Although an optimal dosage is defined, for the treatment of biotin deficiencies, usually corresponding to 3 tablets per day, it would be more advisable to consult your doctor, who should define the appropriate dose based on the present clinical picture.

Warnings BIODERMATIN ® - Biotin

The use of anticonvulsant drugs could significantly increase the need for biotin, thus requiring a possible adjustment of the dosage.

BIODERMATIN ® contains sucrose, therefore its intake is contraindicated in patients suffering from diabetes, fructose intolerance, glucose / galactose malabsorption syndrome or in case of isomaltase insufficiency.

PREGNANCY AND BREASTFEEDING

Intake of BIODERMATIN ® during pregnancy and the subsequent breastfeeding period should be prescribed and supervised by your doctor.

Interactions

High doses of pantothenic acid could compete with biotin for intestinal absorption due to the similar structure and use of the same transporters.

A similar action is observed following the ingestion of raw egg white, given the presence of avidin, capable of forming biologically inactive complexes with biotin.

Contraindications BIODERMATIN ® - Biotin

BIODERMATIN ® is contraindicated in case of hypersensitivity to the active ingredient and its excipients.

Undesirable effects - Side effects

Biotin intake is usually very well tolerated and free of clinically relevant side effects.

Only in rare cases, especially after taking the drug intramuscularly, have allergic reactions been observed with predominantly cutaneous manifestations.