CALCIO GLUCONATO B BRAUN ® - Calcium gluconate

CALCIUM GLUCONATE B BRAUN ® is a calcium gluconate based drug

THERAPEUTIC GROUP: Solutions that influence electrolyte balance; electrolytes

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications CALCIO GLUCONATO B BRAUN ® - Calcium gluconate

CALCIUM GLUCONATE B BRAUN ® is useful in the treatment of acute symptomatic hypocalcemia.

Action mechanism CALCIO GLUCONATO B BRAUN ® - Calcium gluconate

Calcium gluconate, active ingredient of CALCIUM GLUCONATE B BRAUN ® is the calcium salt of gluconic acid, normally soluble in a watery environment and present in various products of animal origin.

Taken parenterally, it reaches the circulatory stream where, partly present in ionized form partly linked to specific plasma proteins such as albumin, it contributes to the maintenance of the overall pool of this trace element.

The use of calcium by the various tissues will instead be finely regulated by hormonal factors such as parathyroid hormone, calcitonin and vitamin D and by the physiological needs of the organism, which will influence its metabolic fate.

CALCIO GLUCONATO B BRAUN ® therefore, can be used to restore the correct blood concentrations of this mineral, avoiding the onset of hypocalcemia and related diseases such as osteoporosis.

Studies carried out and clinical efficacy

1. CALCIUM AND OVARIAN HYPERSTIMULATION SYNDROME

Interesting study that shows how the intravenous infusion of calcium gluconate can significantly reduce the development of ovarian hyperstimulation syndrome in patients with polycystic ovarian syndrome.

2. CALCIUM CARBONATE AND OSTEOPOROSIS

Work that evaluates the efficacy of intravenous administration of calcium in the first 5 days of life in infants at high risk of hypocalcemia, in avoiding clinical onset and pathological manifestations.

3. CALCIUM AND CHEMOTHERAPY NEUROTOXICITY

Experimental study demonstrating how intravenous administration of calcium can prevent sensory neurotoxicity associated with chemotherapy for patients with colon cancer.

Method of use and dosage

CALCIO GLUCONATO B BRAUN ®

94 mg solution for injection of calcium gluconate per ml:

intravenous administration of calcium gluconate requires the assistance of a healthcare professional.

The therapeutic scheme to be used will vary considerably from individual to individual based on the physical characteristics and the clinical picture of the patient.

All stages of therapy must be supervised by the specialist doctor.

Warnings CALCIO GLUCONATO B BRAUN ® - Calcium gluconate

The clinical importance of CALCIO GLUCONATO B BRAUN ® therapy requires a careful preliminary visit to assess the possible presence of conditions incompatible with intravenous calcium gluconate intake.

Renal disorders, sarcoidosis and cardiovascular diseases are just some of the conditions for which particular attention should be paid before administering calcium gluconate.

All patients in therapy should also be subjected to periodic monitoring of blood calcium concentrations, in order to evaluate the therapeutic efficacy and prevent the possible occurrence of side effects.

PREGNANCY AND BREASTFEEDING

The particular pharmacokinetic properties of calcium gluconate and the possible side effects of intravenous administration of this element, push the doctor to opt for oral supplementation, resorting to the use of CALCIUM GLUCONATE B BRAUN ® exclusively in cases of real need.

Interactions

It is very important to remember that the use of digoxin and other cardiac glycosides could increase the toxicity of hypercalcemia, increasing the risk of very dangerous cardiac arrhythmias and manifestations.

Similar effects could also be observed following the simultaneous intake of epinephrine and thiazide diuretics.

Contraindications CALCIO GLUCONATO B BRAUN ® - Calcium gluconate

Intake of CALCIUM GLUCONATE B BRAUN ® is contraindicated in cases of hypercalcemia, hypercalciuria, nephrolithiasis, renal failure, therapy with cardiac glycosides and hypersensitivity to the active ingredient or to one of its excipients.

Undesirable effects - Side effects

Intravenous administration of calcium gluconate exposes the patient to potential clinically relevant side effects.

Dosages that are too high or administered too quickly may be responsible for cardiac and vascular disorders such as hypotension, arrhythmia, collapse, vasodilation, gastrointestinal symptoms such as nausea and vomiting, and systemic symptoms such as hypercalcaemia and associated manifestations.