KESTINE ® - Ebastina

KESTINE ® is a drug based on Ebastine

THERAPEUTIC GROUP: Antihistamines for systemic use - H1 antagonist

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications KESTINE ® - Ebastina

KESTINE ® is indicated for the symptomatic treatment of allergic diseases such as allergic rhinitis, allergic conjunctivitis and chronic idiopathic urticaria.

Mechanism of action KESTINE ® - Ebastina

The antihistamine activity of KESTINE ® is guaranteed by the presence of its active ingredient Ebastine, counted among the antagonists of the second generation H1 receptors, characterized by reduced effects on the central nervous system, therefore by a higher tolerability than its predecessors of first generation.

This difference is due to the inability of Ebastine to cross the blood brain barrier, producing its effects at the nervous level, and to bind only histamine H1 receptors with high affinity, while also reducing the anticholinergic potential, often associated with major cardiovascular disorders.

This mechanism allows the? Ebastina to exert an important action on the respiratory and cutaneous level, reducing the vascular permeability of the perivenular capillaries with the consequent edemigena action, and to control the possible bronchospasms induced by the? Activation of the histamine receptors present on the smooth muscle bronchial.

Everything is also facilitated by the advantageous pharmacokinetic properties, which allow the active ingredient taken orally, to rapidly reach pharmacologically active concentrations, and to maintain the antihistamine activity for several hours after stopping the therapy.

The? Ebastina, after an intense first pass metabolism, and after having completed its therapeutic action, is eliminated mainly through the kidneys.

Studies carried out and clinical efficacy

EBASTIN AND VENTILATORY CAPACITY

Allergy Asthma Proc. 2007 Sep-Oct; 28 (5): 578-81.

Study demonstrating that Ebastine treatment can significantly improve nasal respiratory flow, guaranteeing significant decongestant action in patients with persistent allergic rhinitis.

EBASTIN IN SOLUBLE TABLETS AND THERAPEUTIC EFFECTIVENESS

Clin Ther. 2007 May; 29 (5): 814-22.

Work conducted on healthy non-atopic individuals with the intention of characterizing the antihistamine efficacy of active ingredients such as Ebastine, which demonstrates how the use of 20 mg daily of this drug in soluble tablets can guarantee excellent therapeutic implications.

EBASTIN AND ANTI T-CELL ACTION

Clin Exp Allergy. 2003 Nov; 33 (11): 1544-54.

Interesting cellular study, which demonstrates how? ™ Ebastine may have an inhibitory role with respect to the production of cytokines from Th2, thus being able to play an important role in the control of T-cell mediated diseases such as allergic inflammatory disorders, atopic dermatitis, the? asthma and other autoimmune diseases.

Method of use and dosage

KESTINE ®

Ebastine 10 - 20 mg coated tablets.

Therapy with KESTINE ® should be defined, both in the dosages and in the modalities of intake, by the doctor based on the physiopathological characteristics of the patient and the severity of his clinical picture.

However, the daily dose of 10 mg of Ebastine is generally sufficient to guarantee a remission of symptoms both during chronic idiopathic urticaria and during allergic rhinitis, although double dosages have been used successfully in the treatment of more severe rhinitis.

A dosage adjustment would instead be required in patients with severe liver and kidney disease.

Warnings KESTINE ® - Ebastina

Although the use of antihistamines is widespread among citizens, it would be advisable, before embarking on taking KESTINE ®, to consult your doctor, assessing the possible presence of contraindications to the use of drug rather than prescriptive appropriateness.

The administration of KESTINE ® should be done with particular care in patients suffering from liver and kidney diseases, in which the metabolic characteristics of? Ebastine, and in patients suffering from cardiovascular diseases could be seriously compromised.

KESTINE ® contains lactose, therefore its use would be poorly indicated in patients with lactase enzyme deficiency, glucose-galactose malabsorption syndrome and rare hereditary problems of galactose intolerance.

In order to obtain adequate results, it is recommended to stop taking antihistamines at least 48 hours before allergy tests.

Keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

Given the absence of studies able to ascertain the safety profile of Ebastine for fetal health and note the ability of the active principle to cross the placental barrier and the breast filter, it is necessary to extend the aforementioned contraindications to ? ™ use of KESTINE ® also during pregnancy and subsequent breastfeeding period.

Interactions

In order to preserve the safety and efficacy of KESTINE ® therapy, it would be advisable to avoid the simultaneous intake of active ingredients with cardiotoxic potential or marked hepatic tropism.

In any case it is necessary to consult your doctor if the simultaneous administration of other active ingredients becomes necessary.

Contraindications KESTINE ® - Ebastina

The use of KESTINE ® is contraindicated in case of hypersensitivity to the active ingredient or to one of its excipients or to other structurally related molecules, in patients suffering from severe liver disease and in children under the age of 12 years.

Undesirable effects - Side effects

The use of Ebastine, especially when prolonged over time, could lead to the appearance of dyspepsia, abdominal pain, nausea, vomiting, asthenia, edema, abnormal liver function, insomnia, nervousness, mental disorders, tachycardia and only rarely dermatological reactions from hypersensitivity to the active ingredient.