Colic antispasmin ® Papaverine hydrochloride + belladonna extract

ANTISPASMINA COLICA ® is a drug based on papaverine hydrochloride and belladonna

THERAPEUTIC GROUP: spasmolytics, anticholinergics

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications Colic antispasmin ® Papaverine hydrochloride + belladonna extract

ANTISPASMINA COLICA® is indicated in the treatment of painful manifestations of a spastic nature, due to involuntary contractions of the smooth muscles of the gastro-intestinal tract.

Mechanism of action Colic antispasmin ® Papaverine hydrochloride + belladonna extract

The spasmolytic effect of ANTISPASMINA COLICA ® is due to the combination of two active ingredients:

Papaverine hydrochloride : opiate alkaloid able to interfere with normal intracellular signaling, reducing the contractile capacity of smooth muscle. This property is realized with the reduction of spasms at the gastro-intestinal level, and with a marked vasodilatory action at the vascular level.
Belladonna : belonging to the family of solanaceae, it is particularly rich in alkaloids such as atropine, scopolamine and joscina, known for their marked anticholinergic action mainly on muscarinic receptors of smooth muscle fibrocells. By reducing the excitability induced by acetylcholine, these alkaloids can ensure a significant reduction in smooth muscle contraction, with a significant decrease in spastic episodes.

Studies carried out and clinical efficacy

1 PAPAVERINA AND ERECTILE DEFECTION

Several studies have highlighted a particular utility of one of the active ingredients of ANTISPASMINE COLICA (papaverine) in the treatment of erectile dysfunction. This effect could be given by the relaxing action of the papaverine on the smooth vascular musculature, with a significant increase in the vascular flow in the penile area. See also: papaverine and erectile dysfunction

2. PAPAVERINA AND COLOSSIA BY INTOXICATION

This study has shown that papaverine may be particularly important in the treatment of colitis induced by toxic agents, such as dextran sodium sulfate. More precisely, this action would be expressed in counteracting the vasoconstriction of intestinal arterioles induced by the harmful compound, responsible for bleeding, weight loss and intestinal pain.

3. BELLADONNA AND IRRITABLE COLONY SYNDROME

The administration of Belladonna and fenobabital extracts ensured a significant regression of symptoms associated with irritable bowel syndrome. More precisely, the best results have been obtained in the control of nervousness and sleep disorders, rather than in reducing the preeminent diarrhea.

Method of use and dosage

ANTISPASMINA COLICA ® confetti type "NORMALE" (papaverine hydrochloride 10 mg + belladonna titred in josciamina to 1% - 10mg): for adults we recommend from 2 to 6 confetti per day;

ANTISPASMINA COLICA ® confectionery type "FORTE" (papaverine hydrochloride 50 mg + belladonna titrated in 1% josciamina - 10mg): 1 to 3 confetti per day are recommended for adults.

It is advisable to take the whole sugared almonds before meals or when needed, so that they can reach the intestine intact, exercising the desired spasmolytic action.

In case of diarrhea or hypermotility of the intestine, the confetti could pass unaltered in the intestinal tract and be intact evacuated without having carried out its therapeutic action. Exclusively in this case, it may be useful to break up the candy before taking it

Warnings Colic antispasmin ® Papaverine hydrochloride + belladonna extract

ANTISPASMINA COLICA ® contains alkaloids of various kinds, including some with a marked anticholinergic activity. Therefore it should be used only in case of actual need and always after consulting your doctor.

In general, anticholinergics contained in ANTISPASMINA COLICA ® could:

Cause episodes of gastro-esophageal reflux;
Reduce bronchial secretions with consequent breathing difficulties;
Interact with different pharmaceutical classes.

The use of ANTISPASMINA COLICA ® should therefore be limited in the case of chronic obstructive respiratory diseases, gastro-oesophageal reflux, diseases of the cardiovascular system and alterations of the psychic sphere.

ANTISPASMINA COLICA ® can determine an alteration of the perceptive capacities and induce sleepiness; therefore it is not recommended to use it before driving.

PREGNANCY AND BREASTFEEDING

Given the strong presence of opiate substances, the use of ANTISPASMINA COLICA ® during pregnancy and lactation is NOT RECOMMENDED.

Interactions Antispasmin colica ® Papaverine hydrochloride + belladonna extract

The active ingredients present in ANTISPASMINA COLICA ® can interact with:

Tricyclic antidepressants and amantadine, accentuating the effect.
Anticholinergics of various kinds, enhancing their effects;
Antihistamines, capable of interfering with the normal functioning of the drug;
Parasipathomimetic agents, which cancel the therapeutic effect;
Sulfonamides and beta blockers.

Contraindications Colic antispasmin ® Papaverine hydrochloride + belladonna extract

ANTISPASMINA COLICA ® is contraindicated in children under the age of 12, in pregnant and lactating women, in case of known hypersensitivity to the components, glaucoma, pyloric stenosis, prostatic hypertrophy and other stenosing diseases of the digestive and urinary tract, intestinal atony of the elderly and of debilitated subjects, ulcerative colitis, myasthenia gravis, in patients with autonomic nervous system disorders, in carriers of hepato-renal diseases, hyperthyroidism or coronary heart disease, in cardiac tachyarrhythmias, in arterial hypertension and in congestive heart failure.

Undesirable effects Colic antispasmin ® Papaverine hydrochloride + belladonna extract

Already at therapeutic doses of ANTISPASMINA COLICA ® you can record episodes of:

dry mucosa of the oral cavity;
nausea and vomit;
alterations of ocular tone and visual disturbances;
dizziness;
difficulty with urination and constipation;
gastroesophageal reflux;
retro-sternal pain.

High doses of ANTISPASMINA COLICA ® could determine:

urinary retention;
cardiac arrhythmias;
breathing difficulties;
state of mental confusion;
agitation and tremors.

In case of hypersensitivity to ANTISPASMINA COLICA ® to one of its products, various types of skin reactions may occur, itching, breathing difficulties and jaundice with abnormal liver function.