E-Vitum ® - Tocopherol

E-VITUM ® is a drug based on alpha tocopherol acetate

THERAPEUTIC GROUP: Vitamins: Tocopherol

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications E-Vitum ® - Tocopherol

E-VITUM ® is indicated in the prevention and treatment of vitamin E deficiency states, often associated with neuropathies and lipid malabsorption.

Action mechanism E-Vitum ® - Tocopherol

Vitamin E, also called alpha tocopherol in the most biologically active form, is a fat-soluble vitamin, present above all in vegetable oils, important in supporting the antioxidant capacity of the cell.

In fact, together with other molecules such as vitamin C, coenzyme Q10, lipoic acid and glutathione, it is the main pull of endogenous antioxidants, involved in the detoxification of oxygen free radicals and in the protection of cellular structures from oxidative damage.

More precisely, given its chemical nature, alpha tocopherol has proved useful in protecting membrane lipids, targets of the lipid peroxidation reaction, responsible for the loss of cellular functionality associated with serious pathologies such as neuropathies and cardiovascular pathologies, especially atherosclerotic.

The absorption of this vitamin is carried out at the intestinal level, thanks to the emulsifying action of bile salts, while the distribution within the organism is guaranteed by the plasma lipoproteins and the subsequent elimination from the detoxifying action of the bile.

Studies carried out and clinical efficacy

1.THE VITAMIN AND IN THE TREATMENT OF THE FIRST TYPE DIABETES

Clin Lab. 2011; 57 (5-6): 379-86.

Interesting work that shows how supplementation with 600 mg of vitamin E can reduce oxidative stress in patients with type 1 diabetes mellitus, also improving different metabolic parameters.

2. VITAMIN AND AND OSTEOPOROSIS

J Bone Miner Res. 2012 Feb 3.

Study that seeks to characterize the metabolic effects of alpha tocopherol on bone metabolism. More precisely, the researchers assume that alpha-tocopherol-based supplements can reduce the blood concentrations of gamma tocopherol, a form of vitamin E that seems to play a protective role in relation to bone tissue, reducing resorption and improving deposition.

3. VITAMIN AND THE PREVENTION OF CARDIOVASCULAR DISEASES

Pharmacogenomics. 2010 May; 11 (5): 675-84.

The administration of vitamin E in patients with diabetes mellitus with a particular haptoglobin genotype, would seem to significantly reduce the risk of developing cardiovascular diseases, thus lengthening life expectancy by about 3 years.

Method of use and dosage

E-VITUM ® is available in:

Soft capsules of 73.5 mg of alpha tocopherol acetate, equivalent to 100 IU

The daily requirement of vitamin E could be satisfied through the daily intake of 1-3 capsules.

The definition of the specific dosage is up to the doctor, after having carried out a careful evaluation of the physio-pathological characteristics of the patient.

Warnings E-Vitum ® - Tocopherol

The intake of E-VITUM ® should be preceded by a medical examination to ascertain the deficiency of this vitamin, therefore the need to resort to integrative strategies.

It is useful to remember to periodically check the blood sugar level in diabetic patients undergoing insulin treatment, given the ability of the alpha tocopherol to increase the biological efficacy of this hormone.

E-VITUM ® should be kept away from children.

PREGNANCY AND BREASTFEEDING

The intake of E-VITUM ® could also take place during pregnancy and in the subsequent period of breastfeeding, provided this is done under strict medical supervision, and carried out to meet the increased needs.

Interactions

It is known that the biological effects of vitamin E can be added to those of oral anticoagulants, non-steroidal anti-inflammatory drugs and platelet anti-aggregation, thus causing an increased risk of bleeding.

Similarly, this vitamin could enhance the therapeutic effect of insulin and digitalis, thus requiring an adjustment of the doses used.

Contraindications E-Vitum ® - Tocopherol

E-VITUM ® is contraindicated in case of hypersensitivity to the active ingredient and its excipients.

Undesirable effects - Side effects

The administration of vitamin E, according to the dosages and the prescribed dosage regimens, is free of clinically significant side effects, even if the prolonged intake or carried out at too high dosages, could be responsible respectively for blood coagulation and gastro-intestinal disorders.