Carnitine Liquid - Ultimate nutrition

Information on Carnitine Liquid - Ultimate nutrition

Food supplement of L carnitine.

FORMAT

355 ml bottle (liquid format)

COMPOSITION

water

Emulsifier: vegetable glycerine

L carnitine

Pantothenic acid (Vitamin B5)

Preservatives: methylparahydroxy-benzoate and propylparahydroxy benzoate

One dose (3ml measuring cap) contains:

L-Carnitine 200 mg - trimethylated amino acid derivative, mainly synthesized in the liver and kidneys from two essential amino acids, such as methionine and lysine. The biological role of carnitine is now well established: this molecule is able to bind long-chain fatty acids and convey them through a membrane transporter in the mitochondrial matrix, where they undergo the oxidative process (with energy production).

During physical exercise performed at 50 - 60% of VO2 max, fatty acids are the main energy substrate to support performance; however, the physiological reduction of the levels of non-esterified carnitine, which occurs during the exercise itself, significantly affects the maintenance of oxidative, and therefore aerobic, capacity of the muscle subjected to stress, favoring an increase in glucose metabolism, which in turn further inhibits lipid oxidation (reducing the activity of the acyl carnitine transporter). A well-stocked carnitine muscle could therefore better support lipid oxidation, saving muscle glycogen as an energy source. Moreover, during intense lipidic oxidation, carnitine can regularize the acetylCoA / CoA ratio by binding acetyl groups, therefore on the one hand avoiding the accumulation of acetyl groups, potentially harmful to the cell, and on the other increasing the availability of CoA, important for maintaining the flow rate of the citric acid cycle high and thus promoting energy production

Pantothenic acid (Vitamin B5) 2 mg - also known as calcium pantothenate, is part of the synthesis of Coenzyme A (ATP + VitB5 + Cys), which plays a key role in all the reactions in which an acyl group is transferred ( oxidative decarboxylation of pyruvate, α-ketoglutarate and oxidation of fatty acids). It therefore has a central role in both glucose and lipid metabolism, guaranteeing positive control of the stages limiting oxidative processes.

This vitamin is easily introduced through the diet, found mainly in whole grains and in products of animal origin; consequently, there are no deficiencies in the well-fed population. Its daily requirement is estimated at around 6 mg, but it can definitely increase in particular categories such as athletes.

Product features Carnitine Liquid - Ultimate nutrition

This supplement offers an alternative form to the capsules, that is the liquid form, which could be advantageous for those who have problems with swallowing and for the fastest passage of the digestive tract. However, bioavailability appears to be the same as in the capsule form (14/18%), significantly reduced compared to the food form.

The association with vitamin B5 could increase CoA levels and enhance cellular oxidative capacities. For the purposes of news, a 1996 study, however not thoroughly analyzed, shows how the association of B vitamins, and in particular of Choline, can increase the renal reabsorption of carnitine, increasing its blood concentration.

Recommended use by the company - Carnitine Liquid - Ultimate nutrition

Take one dose (measuring cap) of 3ml once a day

Use in sports practice Carnitine Liquid - Ultimate nutrition

The liquid form lends itself well to the dosage modulation, considering that in sports this can rise up to 2.5 grams of L carnitine a day, despite the ministerial lines recommend a dose not exceeding 200 mg / day. Very high doses are useless, given the increased degradation in the intestine and the reduced reabsorption in the kidney. In sports, this supplement is generally used for:

Increase lipid metabolism and facilitate fat loss;
Improve lipid oxidative metabolism, saving muscle glycogen;
Reduce muscle lactic fermentation, therefore also the feeling of fatigue;
Facilitate recovery

Furthermore, in a 2006 article, it was noted that carnitine supplementation in men undergoing physical exercise has increased the expression of testosterone receptors in the muscles.

Rationale for use - Carnitine Liquid - Ultimate nutrition

The literature shows very contrasting studies on the efficacy of carnitine. Certain and documented are the benefits of supplementation for those suffering from established pathologies, characterized by a deficiency of this substance. On the other hand, we get lost in the critical reading of the various articles published on the role of carnitine supplementation in healthy individuals. Many studies, in fact, do not report any advantage in terms of athletic performance, weight loss and decrease in oxidative markers, while other studies show an increase in aerobic potential with reduction of oxidative stress. However, it should be pointed out that these latter studies associate carnitine with controlled diets and intense and planned physical exercise ... but what is the role of carnitine in these benefits? What is the role of physical exercise? Which one of the diet? Certainly, in order to register a benefit in terms of aerobic capacity, increase in lipid metabolism, and therefore loss of fat mass, it is so clear and obvious that having to add carnitine supplementation to a targeted dietary program and predominantly aerobic exercise is inevitable.

Side effects Carnitine Liquid - Ultimate nutrition

At high doses episodes of insomnia, nausea, abdominal cramps, migraine and gastro intestinal disorders may occur, albeit rare.

Precautions for use Carnitine Liquid - Ultimate nutrition

Contraindicated in cases of renal, hepatic, diabetic, pregnancy, lactation, mood disorders.

This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . More information on the critical analysis of Carnitine Liquid - Ultimate nutrition.

BIBLIOGRAPHY

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New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscleFrancis B Stephens, Dumitru Constantin-Teodosiu, and Paul L Greenhaff

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Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism Rebouche CJ.

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Carnitine for fatigue in multiple sclerosis.

Tejani AM, Wasdell M, Spiwak R, Rowell G, Nathwani S. Cochrane Database Syst Rev. 2010 Feb 17; 2: CD007280.

[Clinical and biochemical studies in a case of acute encephalopathy associated with calcium hopanthenate administration]

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Carnitine transport by organic cation transporters and systemic carnitine deficiency.

Lahjouji K, Mitchell GA, Qureshi IA. Division of Medical Genetics, Hôpital Sainte-Justine, 3175 Cote Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada.

L-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot study.

Ciacci C, Peluso G, Iannoni E, Siniscalchi M, Iovino P, Rispo A, Tortora R, Bucci C, Zingone F, Margarucci S, Calvani M.

Oxidative stress in response to aerobic and anaerobic power testing: influence of exercise training and carnitine supplementation.

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Androgenic responses to resistance exercise: effects of feeding and L-carnitine.

Wraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM.

J Strength Cond Res. 2008 Jul; 22 (4): 1130-5.

Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise.

Spiering BA, Kraemer WJ, Hatfield DL, Vingren JL, Fragala MS, Ho JY, Thomas GA, Häkkinen K, Volek JS.