PENSULVIT ® Tetracycline and Sulfamethylthiazole

PENSULVIT ® is a drug based on Tetracycline and Sulfamethylthiazole

THERAPEUTIC GROUP: Ophthalmology - Antimicrobials

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications PENSULVIT ® Tetracycline and Sulfamethylthiazole

PENSULVIT ® is indicated in the topical treatment of external ocular infections generated by microorganisms sensitive to Tetracycline and Sulfamethylthiazole.

The same drug is indicated in pre and post-operative prophylaxis and as a therapeutic adjuvant during trachoma.

Mechanism of action PENSULVIT ® Tetracycline and Sulfamethylthiazole

PENSULVIT ® owes its biological efficacy and its wide spectrum of action to the presence of two active ingredients with an intense antibiotic activity.

More precisely, Tetracycline is an active ingredient extracted from Streptomyces strains, endowed with bacteriostatic or dose-dependent bactericidal activity particularly effective against Gram-negative bacteria.

Penetrated in the cellular environment, Tetracycline is able to bind the 30S ribosomal subunit, inhibiting the lengthening of the peptide chain and thus compromising the biosynthetic abilities of the bacterium, thereby causing death.

Sulfamethylthiazole, on the other hand, is a molecule with anti-metabolic activity, since it can compete with paraminobenzoic acid in its synthesis of folic acid, thus inhibiting the synthesis of a particularly important mediator in the microorganism economy.

This activity is potentially bacterial towards Gram positive, Gram negative and Clamidia Trachomatis bacteria.

Topical application, significantly limiting the systemic absorption of the product, concentrates the therapeutic effects of the drug at the topical level, also reducing the risk of potential side effects.

Studies carried out and clinical efficacy

THE NON-ANTIBIOTIC PROPERTIES OF TETRACYCLINE

Pharmacol Res. 2011 Dec; 64 (6): 614-23. doi: 10.1016 / j.phrs.2011.06.013. Epub 2011 Jun 21.

Federici TJ.

Study that evaluates the non-antibiotic properties of Tetracycline used in ophthalmology, emphasizing the ability of this antibiotic to inhibit the expression of cytokines such as TNF alpha and enzymes such as metal proteases, normally involved in the genesis of various ophthalmic pathologies.

NEUROPROTECTIVE EFFECTS OF TETRACYCLINE

Acta Neurol Scand. 2011 Dec; 124 (6): 417-23. doi: 10.1111 / j.1600-0404.2011.01536.x. Epub 2011 Jun 8.

Mancuso M, Orsucci D, Calsolaro V, LoGerfo A, Allegrini L, Petrozzi L, Simoncini C, Rocchi A, Trivella F, Murri L, Sicilian G.

Italian study, conducted by the University of Pisa, which demonstrates how the administration of Tetracycline can have a neuroprotective effect in neuromuscular and neurodegenerative disorders, particularly in patients suffering from ophthalmological pathologies such as progressive external ophthalmoplegia.

Clinical trials could clarify this evidence.

TETRACYCLE AND TISSUE BIOENGINEERING

Cornea. 2007 Dec; 26 (10): 1239-48.

Builles N, Justin V, André V, Burillon C, Damour O.

Experimental study that demonstrates how Tetracycline can assist extracellular matrix regeneration in tissue bioengineering experimental models. In particular, in this work we focus on the possibility of recreating the cornea in vitro, also with the aid of Tetracycline which seems to intervene in some way on collagen synthesis.

Method of use and dosage

PENSULVIT ®

Ophthalmic ointment of 1 g of Tetracycline and 5 g of Sulfamethylthiazole per 100 g of product.

Timing and method of administration should be defined by the physician based on the clinical characteristics of the patient.

As a rule it is advisable to apply the appropriate quantity of product directly in the conjunctival fornice for 3 or 4 times a day.

Warnings PENSULVIT ® Tetracycline and Sulfamethylthiazole

Topical therapy with PENSULVIT ® should be supervised by medical personnel in order to limit the potential incidence of side effects.

It should be remembered that prolonged use of antibiotics could increase both the development of hypersensitivity reactions such as to worsen the clinical prognosis and the onset of antibiotic resistance mechanisms.

Therefore it is advisable to limit the use of PENSULVIT ® to the strictly necessary time, taking care to contact your doctor if any unwanted reactions appear.

It is recommended to avoid the use of contact lenses during PENSULVIT ® therapy.

PREGNANCY AND BREASTFEEDING

The use of PENSULVIT ® in pregnancy and during breastfeeding should be justified by real clinical needs and constantly supervised by your doctor.

Interactions

Despite the systemic absorption of the active ingredients present in PENSULVIT ® it is of little clinical and pharmacokinetic relevance, it is appropriate to recall the ability of sulfonamides to alter the normal pharmacokinetic properties of oral hypoglycemic agents, anticonvulsants and anticoagulants.