PANOXYL ® Benzoyl Peroxide

PANOXYL ® is a benzoyl peroxide based drug

THERAPEUTIC GROUP: Anti-acne preparations for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications PANOXYL ® Benzoyl peroxide

PANOXYL ® is used in the medical treatment of acne, even in the presence of comedones, papules, pustules and small nodules.

Mechanism of action PANOXYL ® Benzoyl peroxide

Benzoyl peroxide, the active ingredient of PANOXYL ®, is a molecule used in the clinical treatment of acne given the multiplicity of biological activities it is able to exercise.

More precisely, benzoyl peroxide can:

reduce the production of sebum, thus exercising a sebostatic action, useful in reducing the risk of filling the pores, thus compromising the ideal microenvironment for the growth of comedogenic bacterial strains such as Propionibacterium acnes;
induce a modest keratolytic and exfoliating action, able to reduce the typical hyperkeratinization that is observed during acne, regularizing the dermatological environment treated;
directly control the proliferation of Proprionibacterium acnes, through a bacteriostatic action useful in reducing the incidence of inflammatory lesions sustained by bacterial infections.

All the aforementioned actions are also optimizing with good pharmacokinetic properties which allow benzoyl peroxide, following its topical application, to carry out its activity exclusively at the local level.

Studies carried out and clinical efficacy

THE ROLE OF BENZOYL PEROXIDE IN THE TREATMENT OF ACNE

J Drugs Dermatol. 2013 Jun 1; 12 (6): s73-4.

Recent study that evaluates the use of Benzoyl Peroxide in the treatment of Acne in the light of the latest scientific evidence that underlines the continuous and growing onset of antibiotic resistance mechanisms by Proprionibacterium acnes, a microorganism implicated in the genesis of this pathology.

BENZOYL PEROXIDE IN PREADOLESCENTS AFFECTED BY ACNE

J Drugs Dermatol. 2013 Jun 1; 12 (6): 611-8.

Interesting clinical trial conducted on small preadolescent patients between the ages of 9 and 11 demonstrating how the association between benzoyl peroxide and adapalene can be effective and safe in treating acne.

TREATMENT OF ACNE IN PREGNANCY

Drugs. 2013 Jun; 73 (8): 779-87. doi: 10.1007 / s40265-013-0060-0.

Interesting work that puts benzoyl peroxide among the effective and safe active ingredients in the treatment of acne during pregnancy and lactation.

Method of use and dosage

PANOXYL ®

Topical gel at 5 %% Benzoyl peroxide.

Dermatology cream with 4% benzoyl peroxide.

Generally we recommend applying the correct amount of cream or gel once a day and directly on the region affected by the pathological process, after careful cleaning of the same.

In principle, appreciable therapeutic effects require prolonged interventions over time.

Warnings PANOXYL ® Benzoyl peroxide

In order to limit the potential side effects of the drug and optimize its therapeutic efficacy, it would be advisable for the patient taking PANOXYL ® to take care to avoid direct contact of the drug with the eyes, mucous membranes and other affected skin regions from pathological processes of different nature.

The bleaching capacity of benzoyl peroxide should also be considered.

Given the photosensitizing power of this active ingredient, the patient receiving PANOXYL ® should avoid exposure of the treated area to ultraviolet rays.

It is also recommended to keep the medicine in a cool and dry place, out of reach of children.

PREGNANCY AND BREASTFEEDING

The use of PANOXYL ® in pregnancy and during breastfeeding should be limited to cases of real need and always take place under the strict supervision of your doctor.

Interactions

The patient receiving PANOXYL ® should avoid topical application of other drugs.

Contraindications PANOXYL ® Benzoyl peroxide

The use of PANOXYL ® is contraindicated in patients hypersensitive to the active ingredient or to one of its excipients and in patients suffering from dermatological diseases.

Undesirable effects - Side effects

Treatment with benzoyl peroxide, especially when prolonged over time, could lead to the onset of side effects, fortunately local and transient, such as burning, irritation and pain.

The associated adverse reactions sustained by hypersensitivity to the drug are decidedly more rare.