INDOM COLLIRIO ® Indomethacin

INDOM COLLIRIO ® is a drug based on Indomethacin

THERAPEUTIC GROUP: Non-steroidal anti-inflammatory drugs

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications INDOM COLLIRIO ® Indomethacin

INDOM COLLIRIO ® is useful in the treatment of painful states of the anterior segment of the eye, such as those associated with ophthalmological surgery.

Mechanism of action INDOM COLLIRIO ® Indomethacin

INDOM COLLIRIO ® is a drug based on Indomethacin, an active ingredient derived from arylacetic acid and belonging to the category of non-steroidal anti-inflammatory drugs, commonly used in ophthalmology for the treatment of inflammatory conditions affecting the anterior segment of the eye.

The particular selectivity of use is essentially due to the typical pharmacokinetic properties of the medicine, which allow Indomethacin to concentrate very quickly at the level of aqueous humor, maintaining an efficacy of action for a good four hours.

From the molecular point of view, on the other hand, the anti-inflammatory action of Indomethacin is closely linked to the characteristic inhibitory activity exerted on cyclooxygenases, enzymes capable, during various traumatic events, of converting membrane phospholipids such as arachidonic acid to chemical mediators equipped with of pro-inflammatory and pain activity known as prostaglandins.

Different studies show that the induction of Indomethacin can guarantee a significant reduction in the inflammatory infiltrate in place, reducing both the pain stimulus and the tissue damage, as well as exerting a trophic action against the damaged epithelium.

Studies carried out and clinical efficacy

1. THE PHARMACOCINETY OF INDOMETHACIN IN COLLIRIO

J Ocul Pharmacol Ther. 2011 Dec; 27 (6): 571-6. Epub 2011 Nov 7.

Interesting pharmacological work that tries to characterize all the pharmacokinetic characteristics, including the differences, among the various Indomethacin-based products available on the market. Fortunately, all the products seem to have good efficacy and a comparable pharmacokinetic profile.

2. NEW SOLUBILIZATION SYSTEMS

Curr Eye Res. 2011 Mar; 36 (3): 208-16. Epub 2011 Jan 28.

Innovative delivery method characterized by the association of Indomethacin with cyclodextrins. This particular chemical form seems to improve the solubility and stability of Indomethacin in aqueous products, enhancing its therapeutic efficacy.

3 INDOMETHACIN IN PRE-OPERATIVE PHASES.

Graefes Arch Clin Exp Ophthalmol. 2002 Nov; 240 (11): 929-35. Epub 2002 Oct 30.

Study that demonstrates how topical treatment with Indomethacin can be effective in reducing conjunctival inflammation, improving the outcomes of surgery and reducing at the same time the possible complications.

Method of use and dosage

INDOM COLLIRIO ®

Indomethacin 500 mg ophthalmic use suspension for every 100 ml of solution.

The dosing schedule should be defined by the competent doctor, based on the physio-pathological characteristics of the patient, the severity of the clinical picture and the therapeutic goals.

Warnings INDOM COLLIRIO ® Indomethacin

Although INDOM COLLIRIO ® is well tolerated and has no particular side effects, it is necessary to remember that the prolonged use of this product could facilitate the onset of sensitization phenomena, in some cases so serious as to require the suspension of treatment.

In order to maintain the sterility of the product, it is recommended to use all the necessary precautions for use.

PREGNANCY AND BREASTFEEDING

Despite the systemic absorption of Indomethacin, linked to the use of INDOM COLLIRIO ®, is of little significance, the use of this medicine during pregnancy is not recommended given the potential toxic effects of non-steroidal anti-inflammatory drugs on fetal health.

Interactions

Topical ophthalmic administration of Indomethacin minimizes the potential pharmacological interactions expected between INDOM COLLIRIO ® and other active ingredients.

In this regard it would be useful to mention only the possible interfering action of Indomethacin on the local hypotensive activity of drugs commonly used in ophthalmic surgical practice.

Contraindications INDOM COLLIRIO ® Indomethacin

The use of INDOM COLLIRIO ® is contraindicated in patients who are hypersensitive to the active ingredient or to structurally and chemically related products and to the various excipients present in the product.

We do not recommend the use of INDOM COLLIRIO ® even in patients with contact lenses.

Undesirable effects - Side effects

The topical use of Indomethacin is fortunately not associated with the numerous side effects instead foreseen for systemic therapy with non-steroidal anti-inflammatory drugs, although signs can be observed, especially at the local level, such as conjunctival redness and burning, eyelid edema and anterior segment structures eye, keratitis and itching.