OFTAQUIX ® Levofloxacin

OFTAQUIX is a drug based on Levofloxacin

THERAPEUTIC GROUP: Ophthalmology - Antimicrobials

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions OFTAQUIX ® Levofloxacin

OFTAQUIX ® is indicated in the topical treatment of external ocular infections generated by organisms sensitive to Levofloxacin.

Mechanism of action OFTAQUIX ® Levofloxacin

Levofloxacin, active ingredient of OFTAQUIX ®, is an antibacterial belonging to the family of Fluoroquinolones, active against a wide spectrum of Gram positive and Gram negative aerobic microorganisms, often involved in the genesis of external eye infections.

Its mechanism of action, effective even after topical administration, involves the arrest of bacterial DNA replication processes following the inhibition of the activity of bacterial enzymes such as DNA gyrase and DNA topoisomerases, generally involved in processes of replication.

Despite the excellent efficacy of action, often the therapeutic activity of OFTAQUIX ® is compromised by the onset of bacterial resistance mechanisms, such as to prevent the drug from reaching therapeutic concentrations within the microorganism or to effectively bind the therapeutic target, reducing therapeutic success and worsening the clinical prognosis.

Studies carried out and clinical efficacy

EFFECTIVENESS OF LEVOFLOXACINE IN THE PRE-OPERATORY

Vestn Oftalmol. 2012 Nov-Dec; 128 (6): 54-6.

Iusef IuN, Shkoliarenko NIu, Aladinskaia IV, Oia VM, Vorob'eva MV, Ivanov MN.

Clinical study that demonstrates how the application of OFTAQUIX ® two days before the intraocular lens implantation can significantly reduce bacterial and ocular growth, thus improving the post-operative convalescence course.

THE CLINICAL USE OF LEVOFLOXACINE COLLIRES

Drugs. 2009 Jun 18; 69 (9): 1267-86. doi: 10.2165 / 00003495-200969090-00009.

Keating GM.

Interesting Review that reaffirms the usefulness of Levofloxacin based eye drops in determining a clinical improvement of bacterial conjunctivitis and other external eye infections of the eye, also representing an excellent ally in the prevention of post-surgical infectious complications.

THE LEVOFLOXACINE IN THE OCULIST CLINICAL PRACTICE

Klin Oczna. 2005; 107 (4-6): 344-7.

Izdebska J, Szaflik JP.

Study demonstrating the preventive efficacy of Levofloxacin in eye drops in the prevention of post-operative endophthalmitis, comparing it with drugs generally administered intracamerally, and therefore decidedly more invasive.

Method of use and dosage

OFTAQUIX ®

Eye drops of 5.12 mg Levofloxacin hemihydrate, equal to 5 mg of Levofloxacin per ml of eye drops.

Always according to medical indications, it is generally recommended to instill one or two drops of eye drops directly into the affected eye every two hours up to 8 times a day.

Depending on the severity of the clinical picture and the therapeutic response observed, the doctor should define the duration of the therapy.

Warnings OFTAQUIX ® Levofloxacin

OFTAQUIX ® therapy must necessarily be preceded by a careful medical examination aimed at clarifying the infectious origin of the complained symptomatology and any prescriptive appropriateness.

It should be remembered that topical treatment with antibiotics, especially when prolonged over time, may increase the risk of even severe allergic reactions or select antibiotic-resistant microorganisms at the same time.

It is recommended to avoid the use of contact lenses during OFTAQUIX ® therapy.

PREGNANCY AND BREASTFEEDING

The use of OFTAQUIX ® is generally contraindicated during pregnancy and in the subsequent period of breastfeeding, due to the absence of studies able to fully characterize the safety profile of the drug for the health of the fetus and infant.