R-ALA - Allmax Nutrition - alpha-lipoic acid R

Information on R-ALA - Allmax Nutrition - alpha-lipoic acid

R-ALA - ALLMAX NUTRITION

Food supplement based on alpha-lipoic acid.

FORMAT

60 cps bottle

COMPOSITION

Alpha Lipoic Acid

Anti-caking agent: magnesium stearate

Capsule: edible gelatin

One capsule contains: Acid R Alpha Lipoic Acid 125 mg

Product features R-ALA - Allmax Nutrition - alpha-lipoic acid R

Acid R Alpha Lipoic 125 mg - Lipoic acid, a fundamental enzymatic cofactor for the cellular reactions necessary to obtain energy in the presence of oxygen, is partly synthesized by the human organism and to a small extent taken through the diet. As already mentioned, this molecule is easily absorbed in the intestine and. given its structural characteristics, it can easily pass the cell membrane and become available as a cofactor and antioxidant. Its biological role, which is mainly performed in tissues with high aerobic capacity, allows alpha lipoic acid to re-enter both among the essential factors from the metabolic point of view, and in the organic pull of antioxidants. This substance in fact acts directly in the detoxification from ROS, and at the same time regenerates other powerful antioxidants such as Vitamin C, coenzyme Q10 and vitamin E. Therefore, supplements based on alpha lipoic acid have found application in the treatment of diseases induced by excessive oxidative stress, such as neuropathies, neurodegenerative diseases and cardiovascular diseases. Recently, moreover, the ability of lipoic acid to improve the cellular expression of GLUT4, glucose receptor present in insulin-sensitive tissues, has been observed, thus introducing a potential field of application in diabetic pathology.

Further studies have shown, on laboratory guinea pigs, how the dietary integration of alpha lipoic acid facilitates weight loss, but the ways in which it achieves this effect are still not entirely clear. Supporters of supplementation support the anorectic action of this molecule, recording a reduction in daily food intake, while other research groups have observed an intense reduction in protein synthesis.

The question therefore remains whether the descent of the weight derives from loss of fat or lean mass.

Product features R-ALA - Allmax Nutrition - alpha-lipoic acid R

I considered this product for the stereochemical form in which the active ingredient is found. The other supplements analyzed, in fact, do not give indications on the chemical form of lipoic acid, thus appearing in the form of a racemic mixture (ie in the product we will find two similar structurally but different forms in properties). Several studies, however, have shown that the biologically active one is the R form, more present at plasmatic level, but above all more effective in biological terms.

Potential benefits for sports use R-ALA - Allmax Nutrition - alpha-lipoic acid

Lipoic acid has found different applications in sports use, alone or in synergy with other compounds, although important studies concerning the potential benefits that would derive from its use are lacking. It is in fact used: as an adjuvant in low-calorie diets and as an ergogenic substance able to improve oxidative metabolism and increase muscle energy capacity, as well as improving athletic performance and reducing the feeling of fatigue.

However the only effects demonstrated and present in the literature, are those related to the enhancement of antioxidant capacity, with a significant reduction of markers of oxidative damage, and of lipoperoxidation with a significant increase in glutathione levels

Recommended use by the company - R-ALA - Allmax Nutrition - alpha-lipoic acid

1 cps a day in a little water on a full stomach.

The company also recommends simultaneous integration of creatine or protein.

Use in sports R-ALA - Allmax Nutrition - alpha-lipoic acid

Various dosages are proposed by the scientific literature.

In fact between 200/400 mg per day it has been shown to be effective as an antioxidant, reducing the level of ROS (powerful oxidizing agents) and reducing markers of oxidative damage.

Studies relating instead to the antioxidant capacity of lipoic acid in athletic performance, show dosages of 600mg / day for 8 days.

How to optimize its R-ALA activity - Allmax Nutrition - alpha-lipoic acid

Surely, if you wanted to enhance its antioxidant power, alpha lipoic acid could be effectively associated with other antioxidants, such as vitamin E, vitamin C, glutathione and coenzyme Q10. The benefits of antioxidant cocktails have been described several times in the scientific literature, and also seem to be effective in counteracting the increase in muscle damage following intense physical activity, and facilitating subsequent recovery.

Furthermore, in sports, it is used to associate this molecule with chromium picolinate and acetyl L carnitine: this association could optimize mitochondrial oxidative metabolism, both lipidic and carbohydrate, decisively increasing the muscle's energy capacity, and reducing the mechanisms that lead to formation of lactate and the feeling of fatigue.

Caution!!!! however, the synergy between chromium picolinate and lipoic acid could significantly lower blood glucose (an action also documented by scientific studies), and induce an important hypoglycemia.

Furthermore, a study shows that alpha lipoic acid, taken with creatine and sucrose, can increase muscle creatine pull after 5 days, compared to creatine alone or creatine with sucrose.

Rationale for use - R-ALA - Allmax Nutrition - alpha-lipoic acid R

The therapeutic effects of alpha lipoic acid in the treatment of numerous diseases are well established. Few studies have been carried out, instead, on its application in the sports field; however, from these the antioxidant role emerges, which is performed in the reduction of markers of muscular oxidative damage, and in the increase of important antioxidants such as glutathione in its reduced form.

Regarding the association of antioxidants, the literature considers the activity of these to be effective in reducing oxidative damage both in pathological conditions and following physical activity, while the association between alpha lipoic acid and acetyl l carnitine has been documented in treatment of neurodegenerative diseases, in the reduction of mitochondrial function associated with age and in cardiovascular pathologies, proving to be effective in reducing oxidative damage, but above all in preserving the correct mitochondrial function.

Studies on the efficacy of their association in healthy individuals undergoing physical exercise are lacking.

R-ALA - Allmax Nutrition side effects - R alpha-lipoic acid

At doses above 1200 mg / day, side effects such as itching, tingling and gastrointestinal tract infections (diarrhea, vomiting and abdominal cramps) have been documented.

Precautions for use R-ALA - Allmax Nutrition - alpha-lipoic acid R

Contraindicated in cases of renal, hepatic, diabetic, pregnancy and lactation.

R-ALA interactions - Allmax Nutrition - alpha-lipoic acid

Pharmacological - given the ability of lipoic acid to activate intracellular glucose intake, the simultaneous intake of hypoglycemic agents could have an unexpected and marked hypoglycemic effect; you should therefore consult your doctor before use.

Food - given the structure very similar to biotin, the two molecules could compete for the membrane transporter.

This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Further information on the critical analysis of R-ALA - Allmax Nutrition - alpha-lipoic acid R.

BIBLIOGRAPHY

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