PHENISTIL (gel) ® Dimetindene

FENISTIL ® is a drug based on Dimethindene maleate

THERAPEUTIC GROUP: Antipruriginosi including antihistamines, anesthetics, etc.

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications FENISTIL (gel) ® Dimetindene

FENISTIL ® is indicated for the treatment of itchy skin, sunburn and insect bites.

Mechanism of action PHENISTIL (gel) ® Dimethindene

Dimethindene, the active ingredient of FENISTIL ®, is a drug belonging to the vast category of histamine H1 receptor antagonists, therefore endowed with a striking antipruritic, antiedematous and anti-inflammatory power.

By antagonizing the effects of histamine, in addition to inducing the aforementioned effects, Dimethindene is also able to exert a modest local analgesic action, important in alleviating the pain generally associated with the irritative and itchy manifestations of the skin.

The aforementioned activities are assisted by advantageous pharmacokinetic properties which, by limiting the systemic absorption of Dimethindene, following its topical application, control the incidence of the classic side effects associated with systemic therapy with antihistamines, among which mainly those borne by the central nervous system.

Studies carried out and clinical efficacy

ADVERSE REACTIONS TO DIMETINDENE

Contact Dermatitis. 2011 Mar; 64 (3): 170-1. doi: 10.1111 / j.1600-0536.2010.01830.x.

Case report that denounces the appearance of clinically relevant side effects following the topical use of Dimetindene maleate such as contact dermatitis and systemic allergy, so serious as to require hospitalization.

THE EFFICACY OF DIMETHYDENE IN THE TREATMENT OF RHINITIS

Rhinology. 2003 Sep; 41 (3): 159-66.

Clinical trial demonstrating the effectiveness of Dimetindene applied topically by nasal spray in improving the quality of life of patients suffering from seasonal allergic rhinitis.

THE DIMETHYDENE IN THE TREATMENT OF BURNS

Arzneimittelforschung. 1999 Apr; 49 (4): 374-9.

Study that demonstrates the clinical efficacy of Dimetindene in the treatment of sunburn, thus ensuring an improvement in both the symptoms and the inflammatory state of the skin and the injured tissues.

Method of use and dosage

FENISTIL ®

0.1% Dimetindene maleate dermal use gel

Depending on the intensity of the ongoing inflammatory process and the complained symptomatology it is generally recommended to apply the appropriate amount of gel 2-3 times a day on the affected region, gently massaging it in order to favor absorption.

Warnings FENISTIL (gel) ® Dimetindene

The therapy with FENISTIL ® should be preceded by a careful medical examination aimed at clarifying the origin of the complained symptomatology and the relative prescriptive appropriateness.

In order to optimize the therapeutic efficacy, reducing the potential side effects, it would be appropriate for the patient to respect some hygienic-sanitary rules such as:

thoroughly clean your hands after applying the drug;
avoid contact of the drug with exposed eyes and mucous membranes;
avoid the application of the drug on extensive and secreting skin lesions;
avoid direct exposure to solar radiation;
respect medical indications;
consult your doctor if any side effects appear.

It is also recommended to keep the drug out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of FENISTIL ® during pregnancy and in the subsequent period of breastfeeding should be carried out exclusively in cases of real need and always under the strict supervision of your doctor.

Interactions

No clinically relevant drug interactions are currently known.

Contraindications FENISTIL (gel) ® Dimetindene

The use of FENISTIL ® is contraindicated in patients with hypersensitivity to the active ingredient or to one of its excipients, or with particularly showy and secreting skin diseases.

Undesirable effects - Side effects

The use of FENISTIL ®, especially when prolonged for a long time, could determine the appearance of local adverse reactions such as redness, burning, dryness and exacerbation of symptoms.