DERMOLIN ® Fluocinolone

DERMOLIN ® is a drug based on Fluocinolone acetonide

THERAPEUTIC GROUP: Non-associated corticosteroids, dermatological preparations

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions DERMOLIN ® Fluocinolone

DERMOLIN ® is indicated in the treatment of all those local inflammatory diseases sensitive to treatment with corticosteroids.

Dermatitis, eczema, lesions lupeiche, neurodermini, psoriasis, alopecia areata, contact dermatitis, insect bites, burns, traumatic ulcers and erythemas are only some of the potential therapeutic indications for Fluocinolone acetonide.

Mechanism of action DERMOLIN ® Fluocinolone

DERMOLIN ® is a medicinal product based on Fluocinolone acetonide, a steroid derived from hydrocortinsone and fluorinated in order to optimize its therapeutic efficacy.

In a similar way to other corticosteroid drugs, Fluocinolone also owes its anti-inflammatory, vasoconstrictive and antiallergic activity to the ability to easily permeate cell membranes by inducing the expression of Lipocortin, a protein capable of inhibiting the enzyme Fosdolipase A2, blocking the cascade upstream of phlogistic events leading to the formation of inflammatory mediators.

All this translates into the optimal control of the complained symptomatology and the gradual improvement of the patient's clinical conditions.

Everything is also facilitated by the good pharmacokinetic properties of the fluocinolone acetonide applied topically, which by limiting the systemic absorption of the active ingredient guarantee a significant reduction of the potential side effects.

Studies carried out and clinical efficacy

FLUOCINOLONE AND RISK OF CUTANEOUS ATROPHY

Am J Dermatopathol. 2009 Dec; 31 (8): 794-8. doi: 10.1097 / DAD.0b013e3181a9070d.

Work that tries to characterize the risk of skin atrophy following the topical application of Fluocinolone. Fortunately all the data seem to agree on the low risk of this effect even after prolonged treatments up to 24 weeks.

THE FLUOCINOLONE IN DENTISTRY

J Endod. 2011 Feb; 37 (2): 181-4. doi: 10.1016 / j.joen.2010.10.013.

Dentistry study that demonstrates how low concentrations of FLocinolone can have a particular clinical efficacy in promoting the healing of inflamed dental pulp.

THE FLUOCINOLONE IN THE EYE CLINIC

Retina. 2012 Mar; 32 (3): 537-42. doi: 10.1097 / IAE.0b013e31822058bb.

Very recent study demonstrating that implants based on Fluocinolone acetonide may be effective in controlling posterior inflammation in small patients with cataracts and glaucoma.

Method of use and dosage

DERMOLIN ®

0.25% ointment of Fluocinolone acetonide.

In most cases the application of the appropriate amount of ointment directly on the region affected by the inflammatory process 2-3 times a day guarantees a prompt remission of the complained symptomatology.

In other cases, always according to medical indications, the treatment could be enhanced by the use of the occlusive bandage, taking care to replace the dressing every 12 hours, until healing.

Warnings DERMOLIN ® Fluocinolone

Treatment with DERMOLIN ® should be preceded by a careful medical examination in order to clarify the origin of the complained lesions and any prescriptive appropriateness.

The patient should also:

avoid application of the medicine on eyes and mucous membranes;
avoid using the drug for particularly long periods of time;
avoid applying the drug on particularly large skin regions;
clean hands after each application;
contact your doctor immediately following any side effects.

PREGNANCY AND BREASTFEEDING

The use of DERMOLIN ® during pregnancy and in the subsequent period of breastfeeding is generally contraindicated.

Any use, justified by a cost-benefit ratio decidedly in favor of benefits, should necessarily be supervised by specialist medical personnel.

Interactions

No known drug interactions are currently known.

Contraindications DERMOLIN ® Fluocinolone

The use of DERMOLIN ® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients.

Undesirable effects - Side effects

The use of DERMOLIN ® could cause local side effects such as edema, burning, irritation, hair loss, hypertrichosis, skin atrophy, dry skin and dermatitis.

Fortunately, all the potential systemic side effects are rarer.