PROVIRON ® is a Mesterolone based drug
THERAPEUTIC GROUP: Male sex hormones with anabolic effect
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Directions PROVIRON ® - Mesterolone
PROVIRON ® is used in the treatment of symptoms associated with androgen deficiency, and the intellectual and physical decline of old age.
Mechanism of action PROVIRON ® - Mesterolone
The mesterolone contained in PROVIRON ® is a synthetic derivative of testosterone, obtained by methylation of dihydrotestosterone, which makes this hormone resistant to oral intake without undergoing inactivation at the liver level.
In fact taken orally, it is absorbed at the intestinal level, reaching its maximum systemic concentration within 3 hours of intake, and persisting in circulation for about 8 hours.
Linked to plasma proteins and in particular to Sex Hormon Binding Protein, it reaches the various tissues where it is converted into dihydrotesterone and carries out its important therapeutic action especially for:
- the anabolic role, useful for preserving muscle and bone mass while ensuring an increase in hematopoietic activity;
- the sexual role, necessary both in improving erection and sexual power and desire.
One of the main advantages linked to the use of mesterolone, in addition to the easy way of taking it, is represented by the low estrogenic activity that avoids inhibition to the pituitary level of gonadotropin secretion, therefore the subsequent testicular depression, accompanied in the most serious cases also from atrophy.
Studies carried out and clinical efficacy
1. PROVIRON AND SEED QUALITY
Study demonstrating how the use of PROVIRON ® in sub-fertile patients can guarantee an improvement in semen quality in 93% of treated patients, increasing the likelihood of pregnancy.
2. THE CARDIOVASCULAR SIDE EFFECTS OF THE MESTEROLONE ABUSE
Study demonstrating on animal models, how mesterolone abuse can lead to an increase in atherogenic lipoproteins, facilitating the development of atherosclerotic pathologies and cardiac hypertrophy. Fortunately, physical activity seems to counteract this effect.
3. THE MESTEROLONE IN THE TREATMENT OF IDIOPATHIC STERILITY
Work that unintentionally highlights the determining psychological effects in idiopathic male infertility. In this double-blind study, in fact, a significant and comparable improvement in sperm motility was recorded both in the treated group and in the control.
Method of use and dosage
PROVIRON ®
Mesterolone 50 mg tablets:
remembering that the effective dose and duration of treatment varies from patient to patient, and that these should be formulated by the doctor after a careful check-up, the therapeutic range provided for PROVIRON ® varies from 50 - 100 mg of daily mesterolone to be taken in 2-3 different administrations.
Warnings PROVIRON ® - Mesterolone
Despite the presence of mesterolone significantly reduces some risks related to hormone replacement therapy with androgens, the PROVIRON ® intake must necessarily be preceded by a medical examination that evaluates the prescriptive correctness and the possible presence of diseases capable of increasing the risk of side effects.
Consequently the intake of mesterolone in patients suffering from hypertension, heart disease, family history or stories of neoplastic diseases, liver and kidney diseases, epilepsy, should be carefully supervised by your doctor, providing immediate suspension of therapy following the onset of first pathological signs.
The use in prepubera age should instead take place with particular attention, given the possible deleterious effects on bone growth and on the too rapid development of the male genital organs.
PROVIRON ® contains lactose, therefore its intake could be related to the appearance of side effects of the gastro-intestinal tract in patients suffering from lactose intolerance, lactase enzyme deficiency or glucose / galactose malabsorption.
PREGNANCY AND BREASTFEEDING
Mesterolone is a drug reserved for the treatment of exclusively male diseases.
The use of this active ingredient during pregnancy could determine virilization of the fetus with an impairment of the future reproductive abilities of the unborn child.
Interactions
Although clinically relevant direct drug interactions are not known at this time, it should be remembered that in each case androgen, it would be correct to always consider the increased risk of hemorrhage, hypoglycemia and hypertension, linked to the simultaneous intake of anticoagulants, hypoglycemic agents and corticosteroids.
Contraindications PROVIRON ® - Mesterolone
The intake of mesterolone is contraindicated in case of hypersensitivity to the active substance or to one of its excipients, breast cancer, estrogen-dependent neoplasms, cancer and prostatic hypertrophy, history of hepatocarcinoma, hypercalcaemia, nephrotic syndrome, pregnancy and lactation.
Undesirable effects - Side effects
The presence of mesterolone in PROVIRON ® allows to reduce some of the most dangerous side effects related to androgen therapy such as testicular atrophy and oligozoosperima, while nothing can with regard to long-term adverse reactions such as hypercalcemia, water retention and hypertension, excessive psychic and nervous stimulation.
Note
PROVIRON ® is salable only under medical prescription.
PROVIRON ® is an anabolic agent, therefore its use, outside of medical prescriptions on pathological grounds, is prohibited in the race and out of the race.
