SOLDESAM ® Dexamethasone

SOLDESAM ® a dexamethasone based drug

THERAPEUTIC GROUP: Non-associated corticosteroids

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications SOLDESAM ® Dexamethasone

SOLDESAM ® through its various formulations lends itself to the treatment of pathological conditions characterized by inflammatory and allergic processes that require the use of corticosteroids.

Mechanism of action SOLDESAM ® Dexamethasone

SOLDESAM ® is a drug based on "synthetic" hormones belonging to the corticosteroid category.

Dexamethasone, the active ingredient of this medicine, is in fact used with the primary therapeutic goal of protecting various districts and systems from damage caused by the activation of local and systemic inflammatory processes.

The mechanism through which dexamethasone performs this function is due to its modulating capacity of protein synthesis, such as to induce the expression of proteins such as lipocortin, useful to repress phospholipase A2 activity and the subsequent downstream mechanisms responsible for production of inflammatory mediators such as thromboxanes, leukotrienes, prostaglandins and prostacyclins, and at the same time to inhibit the protein synthesis of antibodies, reducing the number of circulating lymphocytes, eosinophils and basophils.

However, these and other biological mechanisms make corticosteroid drugs particularly effective from a therapeutic point of view but equally dangerous due to the high number of side effects.

Studies carried out and clinical efficacy

1. DESAMETASONE AND SEPTIC ARTHRITIS

The addition of desemetasone to antibiotic therapy for the treatment of septic arthritis can already guarantee an improvement in symptoms on the fourth day of therapy, which translates into a reduction in the duration of hospitalization compared to antibiotic therapy alone.

2. DESAMETASONE NEW EVIDENCE

Recent study demonstrating that dexamethasone therapy may play an important role in inducing cell differentiation towards the erythroid line. The increase of erythroid precursors could represent an important effect from the therapeutic point of view, and open new experiments for dexamethasone.

3. DESAMETASONE AND POST-OPERATIVE PAIN

Dexamethasone intake before mastectomy was shown to be useful in reducing nausea, vomiting and post-operative pain by significantly improving the prognosis.

Method of use and dosage

SOLDESAM ®

solution for injection vials of 4 mg dexamethasone sodium phosphate per ml;
Forte: solution for injection of 8 mg of dexamethasone sodium phosphate per 2 ml;
Oral drops of 200 mg of dexamethasone sodium phosphate per 100 ml of solution;
Ointment from 200 mg of dexamethasone sodium phosphate per 100 g of ointment.

The numerous and various pharmacological formulations foreseen for SOLDESAM ® definitely increase the potential uses and the relative dosages.

The choice of the formulation and the dosage therefore belongs exclusively to the doctor, after he has carefully evaluated the patient's state of health, his clinical picture and after having defined the therapeutic goals to be achieved.

Warnings SOLDESAM ® Dexamethasone

Corticosteroid therapy requires medical supervision during both the dosage formulation phase and the subsequent treatment period.

This is particularly important in minimizing the potential risks to the health of the patient while supporting the effectiveness of the therapy.

Particular attention should be paid to patients suffering from osteoporosis, neurological and psychiatric manifestations, diabetes, hypertension and cardiovascular diseases, given the ability of dexamethasone to aggravate the relative clinical picture.

It is also useful to remember that taking corticosteroid drugs could reduce the protective effect of immunizing therapies and at the same time increase the risk of infections.

The numerous adverse reactions affecting the nervous system, such as to significantly reduce the patient's perceptive capacities, could make the use of machinery, the driving of vehicles and all other possible activities that require an intellectual commitment dangerous.

PREGNANCY AND BREASTFEEDING

Although the safety profile of dexamethasone has not yet been defined when taken during pregnancy, the administration of SOLDESAM ® during the entire pregnancy and the subsequent period of breastfeeding should be carried out exclusively in case of real need and under strict supervision tell me.

In this case it is necessary to subject the newborn to tests of the state of adrenal function.

Interactions

The administration of anticonvulsants, antibiotics, anticoagulants, bronchodilators, antacids and non-systemic anti-inflammatory drugs could alter the pharmacokinetic characteristics of dexamethasone taken orally, requiring an adjustment of the dosage.

The administration of SOLDESAM ® in the form of ointment is safer and has no clinically and pharmacokinetically important interactions.

Contraindications SOLDESAM ® Dexamethasone

SOLDESAM ® is indicated in case of hypersensitivity to the active substance or to one of its excipients, in case of active tuberculosis, peptic ulcer, simplex ocular herpes, systemic fungal infections and psychosis.

Undesirable effects - Side effects

Long-term therapy with corticosteroid drugs such as dexamethasone exposes the patient to numerous side effects widespread among the various systems and systems.

The greatest risk occurs during "systemic" therapy with corticosteroids, although topical and epicutaneous administration may, especially in the case of occlusive medications, follow the side effects of systemic therapy.

Among the most widespread adverse reactions it is possible to recall those affecting the cardiovascular system with the appearance of hypertension and heart failure, of the osteo-articular and muscular apparatus with osteoporosis and myopathies, of the nervous system with neurological and psychiatric manifestations, of the gastro-tract enteric disease with increased risk of ulcers and mucosal lesions, endocrine and metabolic changes with changes in nitrogen, glucose and increased risk of hypoadrenalism.

To these are added dermatological manifestations, particularly frequent following the epicutaneous assumption of dexamethasone.