YOMESAN ® is a drug based on Niclosamide
THERAPEUTIC GROUP: Antiparasitic - anthelmintics, anticestodes
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Indications YOMESAN ® Niclosamide
YOMESAN ® is indicated in the treatment of cestode infections such as Tenia saginata, Tenia solium, Diphyllobutrhium latum and others.
Mechanism of action YOMESAN ® Niclosamide
YOMESAN ® is an antiparasitic drug based on Niclosamide, an active ingredient with strong tenicidal activity, and therefore successfully used against the cestodes responsible for human infections.
Taken orally Niclosamide reaches unchanged the gastro-enteric environment where, in the absence of a significant absorption, it concentrates by carrying out its own therapeutic action on site using a molecular mechanism only partially clarified.
More precisely, this active ingredient seems to act at the level of the mitochondria of the parasite, blocking oxidative phosphorylation and inducing a serious energy depletion responsible for the death of the scales, primordial sketch of the adult parasite able to guarantee its adhesion to the intestinal mucosa, thus facilitating the subsequent growth of the proglottids.
The latter, imaginable as body segments but at the same time initiator elements of the biological cycle, in the absence of the scythe, also useful for maintaining the trophic abilities of the parasite, are readily attacked by intestinal lytic enzymes and thus eliminated through the faeces.
Studies carried out and clinical efficacy
NICLOSAMIDE IN SCHISTOSOMIASIS CONTROL
Ann Trop Med Parasitol. 2007 Sep; 101 (6): 479-86.
Clinical trial that defines the efficacy of Niclosamide, taken at low doses, in controlling the spread of schistosomiasis in areas where this parasitosis is evidently endemic.
ACTIVE NICLOSAMIDE AGAINST PSEUDOMONAS
Antimicrob Agents Chemother. 2013 Feb; 57 (2): 996-1005.
Work with very high technological content which, with the aid of Microarray, demonstrates how Niclosamide, besides having an evident and known anthelmintic activity, can also present a potential anti-Pseudomonas Aeuriginosa action, evident with the impressive control activity towards its gene expression.
POTENTIAL ANCHORAGE ROLE OF NICLOSAMIDE
ACS Med Chem Lett. 2013 Feb 14; 4 (2): 180-185. Epub 2013 Jan 15.
Recent study that shows how some derivatives of Niclosamide can be, at least experimentally, effective in suppressing the proliferative rate of tumor cells.
Method of use and dosage
YOMESAN ®
Niclosamide 500 mg tablets for oral use.
Niclosamide therapy, generally characterized by a short duration, should be defined by your doctor based on the age of the patient, his clinical picture and the type of parasite responsible for the infection.
Given the pharmaceutical form of YOMESAN ® it would be advisable to thoroughly chew the tablet, or dissolve it in a homogeneous solution before swallowing it, in order to optimize its therapeutic effectiveness, potentially compromised by the abundant parasite-induced secretion of muchi.
Warnings YOMESAN ® Niclosamide
Before starting treatment with YOMESAN ®, in addition to requiring careful medical advice to assess all the potential contraindications to the use of Niclosamide, it would be appropriate to restore the correct fecal transit, in order to guarantee the correct elimination of the parasite.
In this regard, to facilitate the rapid evacuation of cestode, a purgative could be combined with anthelmintic therapy to avoid the continuous elimination of proglottids in the following days.
At the same time, it would be advisable to apply all the hygienic rules useful to limit the spread of the parasite and in particular of the pregnant proglottids, responsible for potential new biological cycles.
It is also important to remember that this drug is not effective against cysticercosis.
PREGNANCY AND BREASTFEEDING
Despite the studies in the literature seem to agree on the absence of teratogenic and mutagenic effects of Niclosamide taken during pregnancy, in order to minimize potential side effects it would be advisable to avoid taking the drug in the first trimester, considering all with your doctor the potential risks and benefits.
It is evident that in case of inevitable necessity, therapy with YOMESAN ® should be carefully supervised by your gynecologist.
Interactions
Drug interactions worthy of clinical note are currently unknown, except those with alcohol, which should be significantly limited during therapy.
Contraindications YOMESAN ® Niclosamide
The use of YOMESAN ® is contraindicated in case of hypersensitivity to the active ingredient or to one of its excipients.
Undesirable effects - Side effects
The use of YOMESAN ® is generally well tolerated and has no clinically relevant side effects.
Adverse reactions of the gastrointestinal tract and sometimes hypersensitivity reactions have been observed only rarely.
Note
YOMESAN ® is a prescription-only drug.
