CLOREXAN ® Clorexidine

CLOREXAN ® is a drug based on Chlorhexidine gluconate

THERAPEUTIC GROUP: Antiseptics and disinfectants

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications CLOREXAN ® Clorexidine

CLOREXAN ® is indicated in the cleaning and disinfection of injured skin and in the preparation of the skin itself for surgical procedures.

Mechanism of action CLOREXAN ® Chlorhexidine

CLOREXAN ® is a Chlorhexidine based drug, a biguanide compound consisting of cationic residues and lipophilic groups, which influence its mechanism of action.

In fact the chemical and physical characteristics allow Clorexidine to interact with high affinity with the plasma membrane, interposing itself to the phospholipid double layer and thus exerting a detergent action that facilitates the formation of pores with the consequent loss of cellular material and inactivation of the enzymatic systems.

At higher concentrations the same Chlorhexidine determines an important bactericidal effect against Gram positive, Gram negative bacteria, mycobacteria and some fungi, condensing the cell cytoplasm and preventing it from carrying out its own metabolic action.

Topical use also limits the systemic absorption of the active ingredient making it therefore safe and well tolerated.

Studies carried out and clinical efficacy

PREPARATION OF THE OPERATIONAL FIELD WITH CHLOROXIDINE

J Infus Nurs. 2012 Jan-Feb; 35 (1): 44-50. doi: 10.1097 / NAN.0b013e31823d79ba.

Interesting work that demonstrates how the preparation of the operating field with 0.5% chlorhexidine solutions can be useful in reducing the risk of post-operative infections also in catheterization practices.

CHLOREXIDINE IN THE PREVENTION OF VENTILATORY COMPLICATIONS

Heart Lung 2011 Sep-Oct; 40 (5): e115-22. doi: 10.1016 / j.hrtlng.2011.01.006. Epub 2011 Mar 16.

Study demonstrating that early treatment with oral chlorhexidine-based washes in traumatized patients may reduce the risk of pneumonia associated with assisted ventilation, greatly improving the patient's prognosis.

CHLOREXIDINE AND PREVENTION OF MORTALITY? ™ NEONATALE

Pediatrics. 2007 Feb; 119 (2): e330-40. Epub 2007 Jan 8.

A beautiful study conducted on a Nepalese population that shows how washing babies with chlorhexidine can significantly reduce neonatal deaths among preterm births, even by 28%.

Method of use and dosage

CLOREXAN ®

CLOREXAN ® colorless: 0.5% hydroalcoholic solution of Chlorhexidine gluconate;

CLOREXAN ® dye: brown water-based 0.5% chlorhexidine gluconate solution.

The correct disinfectant procedure involves the application of a few ml of product on the injured skin or on the skin to be prepared for the subsequent invasive procedure, using a gauze or swab, taking care to gently massage the area.

The treatment can be repeated 2-3 times a day, should it prove necessary.

Warnings CLOREXAN ® Chlorhexidine

CLOREXAN ® is a drug intended only for external use, therefore it would be important to pay the utmost attention during the application, taking care to avoid direct contact with the eyes or mucous membranes.

The use of CLOREXAN ®, especially if prolonged over time, could cause the appearance of sensitization phenomena, so it may be important to suspend the intake.

PREGNANCY AND BREASTFEEDING

The absence of systemic absorption, following the topical use of CLOREXAN ®, allows the use of the drug also during pregnancy and in the subsequent period of breastfeeding.

Interactions

It is recommended to avoid the simultaneous use of other antiseptics or detergents.

Contraindications CLOREXAN ® Chlorhexidine

The use of CLOREXAN ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients.

Undesirable effects - Side effects

The use of CLOREXAN ® is generally well tolerated and safe.

Only rarely have local adverse reactions such as burning or irritation been observed, such as not to require suspension of treatment.

If the sensitization reactions become more clinically relevant, it would be advisable to immediately contact your doctor with whom to evaluate the possibility of modifying the therapy.