PEVARYL ® Econazole

PEVARYL ® is an econazole based drug

THERAPEUTIC GROUP: Antimycotics for topical use - imidazole derivatives

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions PEVARYL ® Econazole

PEVARYL ® is indicated in the treatment of skin diseases sustained by microorganisms sensitive to Econazole and responsible for mycosis, onychomycosis, pityriasis versicolor, otitis media and other skin diseases.

Mechanism of action PEVARYL ® Econazole

The? Econazole, contained in PEVARYL ®, is an active ingredient with marked anti-fungal activity, directed towards dermatophytes, yeasts, molds and Gram-negative bacteria, therefore also effective against infections caused by mixed flora.

Applied topically, ? ™ Econazole permeates the plasma membranes of the pathogenic microorganism, reaching concentrations within it that inhibit their replicative and vital capacity through:

The inhibition of the enzyme 14 alpha-sterol dimethylase, involved in the synthesis of? Ergosterol, a key element of the plasma membrane whose presence confers rigidity and structure to the cell;
The? Accumulation of intermediate metabolites, able to interfere with the activities of membrane enzymes, important in mediating the trophic and energy functions of the cell.

The great therapeutic efficacy is also guaranteed by the low systemic absorption of the active principle which significantly limits the risk of drug interactions and clinically relevant side effects.

Studies carried out and clinical efficacy

THE ECONAZOLO IN THE TREATMENT OF TINEA PEDIS

J Am Podiatr Med Assoc. 1990 Nov; 80 (11): 583-7.

A study that demonstrates the delleffectiveness of giorno twice-daily application of 1% Econazole cream in the treatment of tinea pedis in a pediatric clinic, also considering the excellent tolerability of the therapy.

THE ECONAZOLE IN THE TREATMENT OF VULVOVAGINAL CANDIDOSIS

Int Med Res. 1990 Sep-Oct; 18 (5): 389-99.

Clinical trial demonstrating the l 1% Econazole cream treatment efficacy in cases of vulvovaginal candidiasis in patients with comorbidities. Remission of symptoms was observed after about 7 days of treatment.

? NEW ECONAZOLO DELIVERY SYSTEMS

J Pharm Sci. 2010 Nov; 99 (11): 4738-45. doi: 10.1002 / jps.22183.

Study that tests new delivery systems for? ™ Econazole nitrate, such as that consisting of nano particles, able to optimize drug release, thus determining a significant improvement in antifungal properties.

Method of use and dosage

PEVARYL ®

1% cream of Econazole nitrate;

™ 1% alcoholic skin solution of Econazole nitrate;

Anea 1% dermal powder of Econazole nitrate;

Ulsione 1% cutaneous emulsion of Econazole nitrate;

Non-alcoholic cutaneous solution at 1 1% of Econazole.

Generally we recommend the application of PEVARYL ® twice a day, on the skin region affected by the mycotic process, taking care to lightly massage the area until the drug is completely absorbed.

In order for the therapy to be effective it is advisable to extend the treatment for a few days beyond the remission of symptoms.

For the methods of use, refer to reading the illustrative leaflet rather than consulting with your doctor.

Warnings PEVARYL ® Econazole

In order to avoid the occurrence of side effects, considering also the alcoholic nature of some PEVARYL ® pharmaceutical formats, it is recommended to avoid the application of the product on the mucous membranes or on the non-intact skin regions.

The presence of excipients with allergenic power could determine the appearance of local reactions from hypersensitivity to the product.

It is recommended to keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of PEVARYL ® during pregnancy and in the subsequent period of breastfeeding should be carried out exclusively under strict medical supervision, in order to avoid the appearance of unpleasant side effects on the unborn child.